Bo Hu
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View article: High Apolipoprotein B Levels are Associated with an Increased Risk of Recurrent Acute Ischemic Stroke: A Nested Case–Control Study
High Apolipoprotein B Levels are Associated with an Increased Risk of Recurrent Acute Ischemic Stroke: A Nested Case–Control Study Open
View article: Screening and validation of diagnostic markers for keloids via bioinformatics analysis
Screening and validation of diagnostic markers for keloids via bioinformatics analysis Open
View article: Computational framework for prioritizing candidate compounds overcoming the resistance of pancancer immunotherapy
Computational framework for prioritizing candidate compounds overcoming the resistance of pancancer immunotherapy Open
Combination therapy has emerged as an effective approach to overcome resistance to immunotherapy. However, only a small number of drugs have been identified with synergistic effects with immunotherapy. Here, we develop a computational fram…
View article: Evolution and Mechanism of Population and Construction Land Decoupling in China: A Case Study of Shandong Province
Evolution and Mechanism of Population and Construction Land Decoupling in China: A Case Study of Shandong Province Open
With the accelerated urbanization in China, the irrational utilization of land resources has triggered a series of ecological challenges. In this context, exploring the decoupling relationship between population and construction land is cr…
View article: Ultrasound-Guided Thoracic Paravertebral Block with Levobupivacaine-Esketamine Combination for Thoracoscopic Lung Cancer Surgery
Ultrasound-Guided Thoracic Paravertebral Block with Levobupivacaine-Esketamine Combination for Thoracoscopic Lung Cancer Surgery Open
Objective: This retrospective cohort study evaluated the efficacy of esketamine combined with levobupivacaine in ultrasound-guided thoracic paravertebral block (TPVB) for improving opioid-sparing analgesia and enhancing recovery after thor…
View article: Research progress on alkaline anion exchange membranes (AEMs) for the application of hydrogen production by water electrolysis
Research progress on alkaline anion exchange membranes (AEMs) for the application of hydrogen production by water electrolysis Open
View article: Carrier-Free Peptide–Daunorubicin–Small Interfering RNA Nanoassembly for Targeted Therapy of Acute Myeloid Leukemia
Carrier-Free Peptide–Daunorubicin–Small Interfering RNA Nanoassembly for Targeted Therapy of Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) continues to represent a substantial unmet therapeutic need in clinical practice. In recent years, peptide–drug conjugates and small interfering RNA (siRNA) drugs have gained considerable attention due to their…
View article: Screening and Validation of Diagnostic Markers for Keloids Via Bioinformatics Analysis
Screening and Validation of Diagnostic Markers for Keloids Via Bioinformatics Analysis Open
View article: Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA
Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA Open
Hyperuricemia is associated with an increased risk of gout, hypertension, diabetes, and cardiovascular diseases. Most mammals maintain normal serum uric acid (SUA) via urate oxidase (Uox), an enzyme that metabolizes poorly-soluble UA to hi…
View article: Detection strip of anti-NGAL antibody coupled with fluorescent microspheres-A novel tool for reliable and accurate prediction of renal injury
Detection strip of anti-NGAL antibody coupled with fluorescent microspheres-A novel tool for reliable and accurate prediction of renal injury Open
The developed test strip, utilizing anti-NGAL antibodies coupled with fluorescent microspheres, effectively detected trace amounts of NGAL protein in serum samples.
View article: Evaluation of Rice–Crayfish Field Fragmentation Based on Landscape Indices: A Case Study of Qianjiang City, China
Evaluation of Rice–Crayfish Field Fragmentation Based on Landscape Indices: A Case Study of Qianjiang City, China Open
Since the 21st century, rice–crayfish fields have been widely distributed in the Yangtze River Basin in China. However, the spontaneous construction of these fields by farmers has given rise to the issue of rice–crayfish field fragmentatio…
View article: A β-Carboline Derivate PAD4 Inhibitor Reshapes Neutrophil Phenotype and Improves the Tumor Immune Microenvironment against Triple-Negative Breast Cancer
A β-Carboline Derivate PAD4 Inhibitor Reshapes Neutrophil Phenotype and Improves the Tumor Immune Microenvironment against Triple-Negative Breast Cancer Open
Triple-negative breast cancer is a highly aggressive and heterogeneous breast cancer subtype characterized by early metastasis, poor prognosis, and high recurrence. Targeting histone citrullination-mediated chromatin dysregulation to induc…
View article: A cobalt-modified covalent organic framework enables highly efficient degradation of 2,4-dichlorophenol in high concentrations through peroxymonosulfate activation
A cobalt-modified covalent organic framework enables highly efficient degradation of 2,4-dichlorophenol in high concentrations through peroxymonosulfate activation Open
A post-modified covalent organic skeleton (JLNU-307-Co) for degradation of 2,4-DCP was prepared. This study provides a broad prospect for the practical application of COF materials in the degradation of organic pollutants.
View article: Risk factors for postoperative recurrence of pT2-3N0M0 esophageal squamous cell carcinoma and patterns of its recurrence
Risk factors for postoperative recurrence of pT2-3N0M0 esophageal squamous cell carcinoma and patterns of its recurrence Open
This study aimed to explore the patterns of postoperative recurrence in patients with pT2-3N0M0 esophageal squamous cell carcinoma (ESCC) and to identify the risk factors for the recurrence. Patients with pT2-3N0M0 ESCC who were treated at…
View article: Impact of ARID1A and TP53 mutations in pediatric refractory or relapsed mature B-Cell lymphoma treated with CAR-T cell therapy
Impact of ARID1A and TP53 mutations in pediatric refractory or relapsed mature B-Cell lymphoma treated with CAR-T cell therapy Open
View article: BCR-ABL1 Transcript and Philadelphia Negative T-Cell Lymphoblastic Lymphoma: A Case Report and Literature Review
BCR-ABL1 Transcript and Philadelphia Negative T-Cell Lymphoblastic Lymphoma: A Case Report and Literature Review Open
Background: Lymphoblastic lymphoma (LBL) is a malignant tumor, with most cases derived from T cells and less than 20% arising from B cells. T-LBL originates from immature T cell precursors or lymphoblasts. It is mainly found in the lymph n…
View article: Highly-tumor-targeted PAD4 inhibitors with PBA modification inhibit tumors in vivo by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils
Highly-tumor-targeted PAD4 inhibitors with PBA modification inhibit tumors in vivo by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils Open
View article: Recent progresses of exosome–liposome fusions in drug delivery
Recent progresses of exosome–liposome fusions in drug delivery Open
Exosomes are membrane-bound nanoscale extracellular vesicles, which produced by almost all organisms. Due to the excellent biocompatibility, long circulation time as well as low immunogenicity, exosomes as naturally-derived drug delivery c…
View article: CORRELATION BETWEEN SOMATIC MUTATIONS AND PROGNOSIS IN PEDIATRIC MATURE B‐CELL LYMPHOMA
CORRELATION BETWEEN SOMATIC MUTATIONS AND PROGNOSIS IN PEDIATRIC MATURE B‐CELL LYMPHOMA Open
Introduction: To investigate the prognostic factors of childhood mature B-cell lymphoma (MBL), especially the significance of somatic mutations in the clinical features and prognosis, by analyzing the clinical chartacteristics, genetic mut…
View article: ANALYSIS TREATMENT OUTCOME OF 46 REFRACTORY/RELAPSED PEDIATRIC MATURE B CELL LYMPHOMA PATIENTS‐MULTI‐CENTER EXPERIENCE FROM CHINA
ANALYSIS TREATMENT OUTCOME OF 46 REFRACTORY/RELAPSED PEDIATRIC MATURE B CELL LYMPHOMA PATIENTS‐MULTI‐CENTER EXPERIENCE FROM CHINA Open
Introduction: Aim to find the efficacy treatment strategy for refractory/relapsed(r/r) patients with pediatric mature B-cell lymphoma (MBL) by summarizing the treatment outcome of 46 patients from Chinese Children's Lymphoma Multi-center C…
View article: siRNA targeting ANGPTL3 stands in the spotlight for lipid-lowering therapy
siRNA targeting ANGPTL3 stands in the spotlight for lipid-lowering therapy Open
View article: Multiple-Compression-Rate Csi Feedback for Mm-Wave Massive Mimo Based on Federated Learning
Multiple-Compression-Rate Csi Feedback for Mm-Wave Massive Mimo Based on Federated Learning Open
View article: Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia
Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia Open
Small interfering RNA (siRNA) therapeutic is considered to be a promising modality for the treatment of hyperlipidemia. Establishment of a thermostable clinically applicable delivery system remains a most challenging issue for siRNA drug d…
View article: Hetero-Element-Doped Molybdenum Oxide Materials for Energy Storage Systems
Hetero-Element-Doped Molybdenum Oxide Materials for Energy Storage Systems Open
In order to meet the growing demand for the electronics market, many new materials have been studied to replace traditional electrode materials for energy storage systems. Molybdenum oxide materials are electrode materials with higher theo…
View article: Membrane‐destabilizing ionizable lipid empowered imaging‐guided siRNA delivery and cancer treatment
Membrane‐destabilizing ionizable lipid empowered imaging‐guided siRNA delivery and cancer treatment Open
One of the imperative medical requirements for cancer treatment is how to establish an imaging‐guided nanocarrier that combines therapeutic and imaging agents into one system. siRNA therapeutics have shown promising prospects in controllin…
View article: Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy
Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy Open
View article: SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells
SERPINE2 feedback regulates EGF/EGFR signaling in human papillary thyroid carcinoma cells Open
Thyroid cancer (TC) is the most prevalent malignant tumor in the endocrine system. Serpin peptidase inhibitor clade E member 2 (SERPINE2) is closely associated with tumor metastasis. The aim of the present study was to investigate whether …
View article: Lipocalin 10 as a New Prognostic Biomarker in Sepsis‐Induced Myocardial Dysfunction and Mortality: A Pilot Study
Lipocalin 10 as a New Prognostic Biomarker in Sepsis‐Induced Myocardial Dysfunction and Mortality: A Pilot Study Open
Introduction . Sepsis‐induced myocardial dysfunction (SIMD) is the most common complications of sepsis and septic shock with extremely high incidence and mortality. Lipocalin 10 (Lcn10) has recently been identified as a potential biomarker…
View article: Therapeutic siRNA: state of the art
Therapeutic siRNA: state of the art Open
View article: siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin
siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin Open