Boris Mankovsky
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View article: Impact of Oral Semaglutide on Kidney Outcomes in People With Type 2 Diabetes: Results From the SOUL Randomized Trial
Impact of Oral Semaglutide on Kidney Outcomes in People With Type 2 Diabetes: Results From the SOUL Randomized Trial Open
OBJECTIVE To examine the effects of oral semaglutide on kidney outcomes in people with type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD) and/or chronic kidney disease (CKD). RESEARCH DESIGN AND METHODS SOUL (NCT03914…
View article: EndoCompass Project: Research Roadmap for Diabetes, Obesity, and Metabolism
EndoCompass Project: Research Roadmap for Diabetes, Obesity, and Metabolism Open
Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal …
View article: EndoCompass project: research roadmap for diabetes, obesity, and metabolism
EndoCompass project: research roadmap for diabetes, obesity, and metabolism Open
Background Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human well-being. Analysis of the CORDIS database reveals a persistent gap between the societal i…
View article: Endothelial dysfunction and reduced glomerular filtration rate in individuals of different age groups with signs of cardio-renal-metabolic syndrome: angio- and renoprotection pathways
Endothelial dysfunction and reduced glomerular filtration rate in individuals of different age groups with signs of cardio-renal-metabolic syndrome: angio- and renoprotection pathways Open
Background. Cardio-renal-metabolic syndrome (CRMS) is a cluster of pathological conditions that combine metabolic disorders, cardiovascular dysfunction, and kidney damage, forming an interconnected system of complications. Endothelial dysf…
View article: Hyperosmolar hyperglycemic state in elderly and senile patients
Hyperosmolar hyperglycemic state in elderly and senile patients Open
Hyperglycemic hyperosmolar state (HHS) is an acute and life-threatening hyperglycemic emergency that often occurs in elderly and senile patients and leads to significant morbidity and mortality. The aim of this review is to provide up-to-d…
View article: Prediction of coronary artery disease risk in patients with type 2 diabetes mellitus: a mathematical model
Prediction of coronary artery disease risk in patients with type 2 diabetes mellitus: a mathematical model Open
Coronary artery disease (CAD) is one of the most prevalent and life-threatening complications in individuals with type 2 diabetes mellitus (T2DM). The aim of this study was to develop a mathematical model for predicting the risk of CAD in …
View article: Diagnostics of pain syndrome in elderly and senile patients
Diagnostics of pain syndrome in elderly and senile patients Open
The prevalence of pain syndrome increases with age, reaching maximum values among elderly people, which is associated with the presence of comorbidities in this cohort of patients. The intensity of pain syndrome and the effect of treatment…
View article: Comparative analysis of the clinical and metabolic profile of patients with type 2 diabetes mellitus depending on the presence of diabetic polyneuropathy
Comparative analysis of the clinical and metabolic profile of patients with type 2 diabetes mellitus depending on the presence of diabetic polyneuropathy Open
Background. Type 2 diabetes mellitus (T2DM) is one of the most prevalent chronic non-communicable diseases, with diabetic polyneuropathy (DPN) being a serious complication that significantly impairs quality of life and contributes to disab…
View article: Характеристика фенотипу пацієнтів із цукровим діабетом 2-го типу та ішемічною хворобою серця
Характеристика фенотипу пацієнтів із цукровим діабетом 2-го типу та ішемічною хворобою серця Open
The aim – to evaluate the phenotypic characteristics of patients with type 2 diabetes mellitus (T2DM) with and without coronary artery disease (CAD), identify key features that may have prognostic significance, and assess their impact on t…
View article: Supplemental therapy for diabetes: a necessity or an additional choice?
Supplemental therapy for diabetes: a necessity or an additional choice? Open
Diabetes mellitus (DM) is a chronic endocrine and metabolic disease that occurs as a result of absolute or relative insulin deficiency under the influence of a combination of genetic and exogenous factors. Effective management of DM includ…
View article: Diabetes and natural and man-made disasters: prevention, preparation, response and recovery
Diabetes and natural and man-made disasters: prevention, preparation, response and recovery Open
Both the global prevalence of diabetes and the frequency of natural and man-made disasters are increasing. Of all chronic diseases, the consequences of sudden loss of medical supplies are most serious for those with diabetes, with people l…
View article: Frequency of detection and factors of elevated levels of diabetes-associated autoantibodies in the blood of patients with clinical type 2 diabetes mellitus
Frequency of detection and factors of elevated levels of diabetes-associated autoantibodies in the blood of patients with clinical type 2 diabetes mellitus Open
Background. Some patients with clinical course of type 2 diabetes mellitus (T2DM) exhibit signs of an autoimmune process, particularly an elevated level of glutamic acid decarboxylase autoantibodies (GADA), indicating an autoimmune compone…
View article: Relationship between body mass index, waist circumference and clinical and laboratory parameters in men of different ages with type 2 diabetes
Relationship between body mass index, waist circumference and clinical and laboratory parameters in men of different ages with type 2 diabetes Open
The relationship between obesity and type 2 diabetes mellitus (T2DM) has long been recognized and clearly explains the high prevalence of T2DM in many countries. T2DM is a major risk factor for cardiovascular diseases (CVD). However, the d…
View article: Synergistic effects of Lespedeza and artichoke extracts in the therapy of chronic kidney disease: mechanisms and perspectives
Synergistic effects of Lespedeza and artichoke extracts in the therapy of chronic kidney disease: mechanisms and perspectives Open
Chronic kidney disease (CKD) is a major global health issue associated with oxidative stress, inflammation, and fibrosis. Traditional pharmacological approaches have limitations due to side effects and insufficient efficacy in the late sta…
View article: Вплив перенесеного COVID-19 на основні чинники кардіоваскулярного ризику в осіб різного віку
Вплив перенесеного COVID-19 на основні чинники кардіоваскулярного ризику в осіб різного віку Open
The aim – to clarify the impact of SARS-CoV-2 on the development of metabolic disorders in middle-aged and elderly people in the period from 1 to 3 months after suffering from the disease of COVID-19.Materials and methods. All of included …
View article: Expert Clinical Interpretation of Continuous Glucose Monitor Reports From Individuals Without Diabetes
Expert Clinical Interpretation of Continuous Glucose Monitor Reports From Individuals Without Diabetes Open
Background: Clinical interpretation of continuous glucose monitoring (CGM) data for people without diabetes has not been well established. This study aimed to investigate concordance among CGM experts in recommending clinical follow-up for…
View article: Взаємозв’язок між хронічною хворобою нирок та серцево-судинною патологією у хворих на цукровий діабет 2-го типу різного віку
Взаємозв’язок між хронічною хворобою нирок та серцево-судинною патологією у хворих на цукровий діабет 2-го типу різного віку Open
The aim – to analyze the relationship between chronic kidney disease (CKD) and cardiovascular pathology in patients with type 2 diabetes (T2D) of different ages.Materials and methods. A total of 233 patients with T2D aged 30-80 years were …
View article: Assessment of cardiometabolic age and aging rate in individuals with type 2 diabetes
Assessment of cardiometabolic age and aging rate in individuals with type 2 diabetes Open
Background. Aging is associated with changes in organs and systems that contribute to the development of age-related pathology. Accelerated aging is characterized by metabolic disorders that create conditions for the development of type 2 …
View article: Global Framework for Scientific Event: A 32-Country and 118-Expert Collaborative Effort
Global Framework for Scientific Event: A 32-Country and 118-Expert Collaborative Effort Open
Introduction Despite numerous efforts to define and categorize scientific events, a consensus remains elusive, complicating the understanding and classification of such events. The current study aims to establish clear, consensus-based def…
View article: CORONARY MICROVASCULAR DYSFUNCTION IN PATIENTS AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION DUE TO ACUTE CORONARY SYNDROME
CORONARY MICROVASCULAR DYSFUNCTION IN PATIENTS AFTER URGENT PERCUTANEOUS CORONARY INTERVENTION DUE TO ACUTE CORONARY SYNDROME Open
Background. Possible cause of residual myocardial ischemia after urgent PCI during ACS is coronary microvascular dysfunction. Aim: To study the frequency of coronary microvascular dysfunction in patients who underwent urgent PCI due to ACS…
View article: Expert Opinion on Optimising Type 2 Diabetes Treatment Using Fixed-Ratio Combination of Basal Insulin and GLP-1 RA for Treatment Intensification and Simplification
Expert Opinion on Optimising Type 2 Diabetes Treatment Using Fixed-Ratio Combination of Basal Insulin and GLP-1 RA for Treatment Intensification and Simplification Open
The management of type 2 diabetes (T2D) often necessitates treatment intensification, and sometimes simplification to achieve glycaemic targets and mitigate complications. This expert opinion paper evaluates the use and positioning of the …
View article: Inclisiran Usage in Very High-Risk Patients with Dyslipidemia Resistant to Statins and Ezetimibe Therapy
Inclisiran Usage in Very High-Risk Patients with Dyslipidemia Resistant to Statins and Ezetimibe Therapy Open
Background. Complications of systemic atherosclerosis (myocardial infarction, ischemic stroke) are the main causes of mortality and disability in the modern world. The relevance of this problem is determined by its scale: the number of dea…
View article: EFFECT OF DRUGS WITH METABOLIC ACTION ON OXIDATIVE STRESS DEVELOPMENT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
EFFECT OF DRUGS WITH METABOLIC ACTION ON OXIDATIVE STRESS DEVELOPMENT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Open
It was shown that the combined oral use of drugs with a metabolic effect - armadine at a dose of 300 mg per day and trizipin at a dose of 500 mg per day for 60 days led to inhibition of the oxidative stress damaging effect on its molecular…
View article: The Influence of Myocardial Revascularization on the Condition of the Distal Part of Coronary Arteries in Patients with Type 2 Diabetes Mellitus
The Influence of Myocardial Revascularization on the Condition of the Distal Part of Coronary Arteries in Patients with Type 2 Diabetes Mellitus Open
The aim. To study the dynamics of the internal lumen of the distal part of coronary arteries after percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) in patients with type 2 diabetes mellitus Materials and m…
View article: Development of hypoglycemia in patients with COVID-19: coincidence or the result of treatment?
Development of hypoglycemia in patients with COVID-19: coincidence or the result of treatment? Open
Hypoglycemia is a common complication of diabetes mellitus (DM), which also complicates the course of COVID-19. The aim: The purpose of this work is to analyze the available scientific information on the causes and risk factors of hypoglyc…
View article: Development of hypoglycemia in patients with COVID-19: coincidence or the result of treatment?
Development of hypoglycemia in patients with COVID-19: coincidence or the result of treatment? Open
Hypoglycemia is a common complication of diabetes mellitus (DM), which also complicates the course of COVID-19. The aim: The purpose of this work is to analyze the available scientific information on the causes and risk factors of hypoglyc…
View article: The role of the albumin-to-creatinine ratio in the diagnosis of diabetic kidney disease (literature review and own findings)
The role of the albumin-to-creatinine ratio in the diagnosis of diabetic kidney disease (literature review and own findings) Open
Based on our own practical experience and data from scientific literature, we can assert that measuring the ratio of albumin to creatinine and calculating the glomerular filtration rate are important tools for the timely diagnosis of chron…