Boris Rudolfs
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View article: Structural evidence for metal ion catalysis in the ribosome
Structural evidence for metal ion catalysis in the ribosome Open
Ribosomes synthesize proteins with an RNA-only active site across all domains of life, yet the details of the catalytic mechanism have remained elusive despite decades of high-resolution ribosome structures. Here, we provide structural evi…
View article: Scaffold-enabled high-resolution cryo-EM structure determination of RNA
Scaffold-enabled high-resolution cryo-EM structure determination of RNA Open
Cryo-EM structure determination of protein-free RNAs has remained difficult with most attempts yielding low to moderate resolution and lacking nucleotide-level detail. These difficulties are compounded for small RNAs as cryo-EM is inherent…
View article: Scaffold-enabled high-resolution cryo-EM structure determination of RNA
Scaffold-enabled high-resolution cryo-EM structure determination of RNA Open
Cryo-EM structure determination of protein-free RNAs has remained difficult with most attempts yielding low to moderate resolution and lacking nucleotide-level detail. These difficulties are compounded for small RNAs as cryo-EM is inherent…
View article: Redesigning the Eterna100 for the Vienna 2 folding engine
Redesigning the Eterna100 for the Vienna 2 folding engine Open
The rational design of RNA is becoming important for rapidly developing technologies in medicine and biochemistry, spurring development of numerous RNA secondary structure design algorithms and benchmarks to evaluate their performance. How…