Boris W. Kramer
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View article: Neuro-Cells Mitigate Amyloid Plaque Formation and Behavioral Deficits in the APPswe/PS1dE9 Model of Alzheimer Disease While Also Reducing IL-6 Production in Human Monocytes
Neuro-Cells Mitigate Amyloid Plaque Formation and Behavioral Deficits in the APPswe/PS1dE9 Model of Alzheimer Disease While Also Reducing IL-6 Production in Human Monocytes Open
Neuroinflammation is a key feature of Alzheimer’s disease (AD), and stem cell therapies have emerged as promising candidates due to their immunomodulatory properties. Neuro-Cells (NC), a combination of unmodified mesenchymal stem cells (MS…
View article: Author Correction: Longitudinal fecal microbiota and volatile metabolomics preceding necrotizing enterocolitis in preterm infants: a case–control study
Author Correction: Longitudinal fecal microbiota and volatile metabolomics preceding necrotizing enterocolitis in preterm infants: a case–control study Open
View article: Longitudinal fecal microbiota and volatile metabolomics preceding necrotizing enterocolitis in preterm infants: a case–control study
Longitudinal fecal microbiota and volatile metabolomics preceding necrotizing enterocolitis in preterm infants: a case–control study Open
View article: Changes in adrenomedullin in bronchoalveolar lavage fluid with chorioamnionitis in a sheep-based model
Changes in adrenomedullin in bronchoalveolar lavage fluid with chorioamnionitis in a sheep-based model Open
the present results showing AM BALF changes in a sheep-based model support the AM role in the hemodynamic patterns due to CA and BPD occurrence and open the way to further studies investigating the role of vasoactive agents as trustable ma…
View article: Neonatal Hypoglycemia and Neurodevelopmental Outcomes—An Updated Systematic Review and Meta-Analysis
Neonatal Hypoglycemia and Neurodevelopmental Outcomes—An Updated Systematic Review and Meta-Analysis Open
Background and Objective: The effects of neonatal hypoglycemia on the developing brain are well known, resulting in poor neurological outcomes. We aimed to perform an updated meta-analysis on neonatal hypoglycemia, the severity of hypoglyc…
View article: Improved Efficacy of Delayed Treatment with Human Bone Marrow-Derived Stromal Cells Evaluated in Rats with Spinal Cord Injury
Improved Efficacy of Delayed Treatment with Human Bone Marrow-Derived Stromal Cells Evaluated in Rats with Spinal Cord Injury Open
The treatment of spinal cord injury (SCI) with uncultivated human bone marrow-derived stromal cells (bmSCs) prepared by negative selection has been proposed to be therapeutically superior to treatment with stem cells that were expanded in …
View article: DOSE- AND AND TIME-DEPENDENT EFFECTS OF TREATMENT WITH HUMAN BONE MARROW-DERIVED STROMAL CELLS IN A RAT MODEL OF SPINAL CORD INJURY
DOSE- AND AND TIME-DEPENDENT EFFECTS OF TREATMENT WITH HUMAN BONE MARROW-DERIVED STROMAL CELLS IN A RAT MODEL OF SPINAL CORD INJURY Open
View article: Incidence, predictors, and impact of acute post-operative pain after cranial neurosurgery: A prospective cohort study
Incidence, predictors, and impact of acute post-operative pain after cranial neurosurgery: A prospective cohort study Open
Objectives: Pain is common after craniotomy. Its incidence and predictors in developing nations are not adequately studied. We aimed to assess the incidence, predictors, and impact of acute post-operative pain after intracranial neurosurge…
View article: Effects of multiple pro-inflammatory stimuli in utero on the ileum of extremely premature ovine fetuses
Effects of multiple pro-inflammatory stimuli in utero on the ileum of extremely premature ovine fetuses Open
Introduction Chorioamnionitis is common in preterm birth and associated with a higher risk of intestinal inflammation and necrotizing enterocolitis. The intestinal inflammation influences the enteric nervous system development. We hypothes…
View article: Opioid versus Nonopioid Analgesia for Craniotomy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Opioid versus Nonopioid Analgesia for Craniotomy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Open
View article: Acute Lung Functional and Airway Remodeling Effects of an Inhaled Highly Selective Phosphodiesterase 4 Inhibitor in Ventilated Preterm Lambs Exposed to Chorioamnionitis
Acute Lung Functional and Airway Remodeling Effects of an Inhaled Highly Selective Phosphodiesterase 4 Inhibitor in Ventilated Preterm Lambs Exposed to Chorioamnionitis Open
Phosphodiesterase (PDE) inhibition has been identified in animal studies as a new treatment option for neonatal lung injury, and as potentially beneficial for early lung development and function. However, our group could show that the inha…
View article: Association between duration of early empiric antibiotics and necrotizing enterocolitis and late-onset sepsis in preterm infants: a multicenter cohort study
Association between duration of early empiric antibiotics and necrotizing enterocolitis and late-onset sepsis in preterm infants: a multicenter cohort study Open
View article: Tauroursodeoxycholic Acid Reduces Neuroinflammation but Does Not Support Long Term Functional Recovery of Rats with Spinal Cord Injury
Tauroursodeoxycholic Acid Reduces Neuroinflammation but Does Not Support Long Term Functional Recovery of Rats with Spinal Cord Injury Open
The bile acid tauroursodeoxycholic acid (TUDCA) reduces cell death under oxidative stress and inflammation. Implants of bone marrow-derived stromal cells (bmSC) are currently under investigation in clinical trials of spinal cord injury (SC…
View article: Short-term pulmonary and systemic effects of hydrocortisone initiated 7–14 days after birth in ventilated very preterm infants: a secondary analysis of a randomised controlled trial
Short-term pulmonary and systemic effects of hydrocortisone initiated 7–14 days after birth in ventilated very preterm infants: a secondary analysis of a randomised controlled trial Open
Objective Observational studies in preterm infants suggest that systemic hydrocortisone improves pulmonary condition but may also lead to systemic adverse effects. We report the short-term pulmonary and systemic effects of hydrocortisone i…
View article: Bayesian Parameter Estimation for Dynamical Models in Systems Biology
Bayesian Parameter Estimation for Dynamical Models in Systems Biology Open
Dynamical systems modeling, particularly via systems of ordinary differential equations, has been used to effectively capture the temporal behavior of different biochemical components in signal transduction networks. Despite the recent adv…
View article: Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology
Interprofessional Consensus Regarding Design Requirements for Liquid-Based Perinatal Life Support (PLS) Technology Open
Liquid-based perinatal life support (PLS) technology will probably be applied in a first-in-human study within the next decade. Research and development of PLS technology should not only address technical issues, but also consider socio-et…
View article: Association Between the Method of Delivery and Respiratory Outcomes in Extremely Preterm and Extremely Low Birth Weight Infants: a Retrospective Cohort Study in Newborns From 2000-2003
Association Between the Method of Delivery and Respiratory Outcomes in Extremely Preterm and Extremely Low Birth Weight Infants: a Retrospective Cohort Study in Newborns From 2000-2003 Open
Background : Extremely preterm (gestational age (GA) <28 weeks) and extremely low birth weight (ELBW) infants (<1000g) are at risk to develop respiratory morbidities like respiratory distress syndrome (RDS), bronchopulmonary dysplasia (BPD…
View article: Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero
Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero Open
View article: Systemic multipotent adult progenitor cells protect the cerebellum after asphyxia in fetal sheep
Systemic multipotent adult progenitor cells protect the cerebellum after asphyxia in fetal sheep Open
Involvement of the cerebellum in the pathophysiology of hypoxic-ischemic encephalopathy (HIE) in preterm infants is increasingly recognized. We aimed to assess the neuroprotective potential of intravenously administered multipotent adult p…
View article: Chorioamnionitis induces enteric nervous system injury: effects of timing and inflammation in the ovine fetus
Chorioamnionitis induces enteric nervous system injury: effects of timing and inflammation in the ovine fetus Open
View article: Introduction of less invasive surfactant administration (LISA), impact on diagnostic and therapeutic procedures in early life: a historical cohort study
Introduction of less invasive surfactant administration (LISA), impact on diagnostic and therapeutic procedures in early life: a historical cohort study Open
View article: A comparison of four different models of acute respiratory distress syndrome in sheep
A comparison of four different models of acute respiratory distress syndrome in sheep Open
Background: Acute respiratory distress syndrome (ARDS) can have various causes. The study objective was to investigate whether different pathophysiologic models of ARDS would show different respiratory, cardiovascular and inflammatory outc…
View article: Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression
Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression Open
Chorioamnionitis (CA) is considered a key risk factor for very preterm birth and for developing early onset sepsis (EOS) in preterm infants, but recent data suggest that CA might be protective against late onset sepsis (LOS). We performed …
View article: Authors’ reply re: Universal screening versus risk-based protocols for antibiotic prophylaxis during childbirth to prevent early-onset Group B streptococcal disease: A systematic review and meta-analysis. (Response to BJOG-20-0671)
Authors’ reply re: Universal screening versus risk-based protocols for antibiotic prophylaxis during childbirth to prevent early-onset Group B streptococcal disease: A systematic review and meta-analysis. (Response to BJOG-20-0671) Open
Dear Editor, We would like to thank Dr. Lamont and colleagues for their interesting commentary.1 The authors point out very pressing topics that deserve more attention than we could provide in the original manuscript.They expressed concern…
View article: Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine Ureaplasma parvum Infection Partly Prevents Liver Inflammation without Interfering with the Enterohepatic Circulation of the Fetal Sheep
Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine Ureaplasma parvum Infection Partly Prevents Liver Inflammation without Interfering with the Enterohepatic Circulation of the Fetal Sheep Open
Chorioamnionitis can lead to inflammation and injury of the liver and gut, thereby predisposing patients to adverse outcomes such as necrotizing enterocolitis (NEC). In addition, intestinal bile acids (BAs) accumulation is causally linked …
View article: Tobacco Smoking During Pregnancy Is Associated With Increased Risk of Moderate/Severe Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis
Tobacco Smoking During Pregnancy Is Associated With Increased Risk of Moderate/Severe Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis Open
Epidemiological evidence and animal studies support that intrauterine exposure to tobacco smoke disturbs lung development and has a negative effect in the pulmonary health of the offspring. Individual studies suggest an association between…
View article: Why do anti-inflammatory signals of bone marrow-derived stromal cells improve neurodegenerative conditions where anti-inflammatory drugs fail?
Why do anti-inflammatory signals of bone marrow-derived stromal cells improve neurodegenerative conditions where anti-inflammatory drugs fail? Open
View article: The potential of glioma-associated oncogene homolog 1 (GLI1) as a therapeutic target in endometriosis
The potential of glioma-associated oncogene homolog 1 (GLI1) as a therapeutic target in endometriosis Open
View article: Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses
Chronic Intra-Uterine Ureaplasma parvum Infection Induces Injury of the Enteric Nervous System in Ovine Fetuses Open
[This corrects the article DOI: 10.3389/fimmu.2020.00189.].
View article: The Interplay Between Reproductive Tract Microbiota and Immunological System in Human Reproduction
The Interplay Between Reproductive Tract Microbiota and Immunological System in Human Reproduction Open
In the last decade, the microbiota, i.e., combined populations of microorganisms living inside and on the surface of the human body, has increasingly attracted attention of researchers in the medical field. Indeed, since the completion of …