Boshen Yan
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View article: Effect of systemic glucocorticoid immunosuppression timing, dose, and duration on overall survival among immune checkpoint inhibitor recipients: a retrospective multicohort study
Effect of systemic glucocorticoid immunosuppression timing, dose, and duration on overall survival among immune checkpoint inhibitor recipients: a retrospective multicohort study Open
Summary Background Systemic immunosuppression (sISP), particularly with glucocorticoids, is commonly used among patients receiving immune checkpoint inhibitor (ICI) therapy. Although recent studies have demonstrated that sISP is associated…
View article: Individualized melanoma risk prediction using machine learning with electronic health records
Individualized melanoma risk prediction using machine learning with electronic health records Open
Background Melanoma is a lethal form of skin cancer with a high propensity for metastasizing, making early detection crucial. This study aims to develop a machine learning model using electronic health record data to identify patients at h…
View article: SpatialCells: automated profiling of tumor microenvironments with spatially resolved multiplexed single-cell data
SpatialCells: automated profiling of tumor microenvironments with spatially resolved multiplexed single-cell data Open
Cancer is a complex cellular ecosystem where malignant cells coexist and interact with immune, stromal and other cells within the tumor microenvironment (TME). Recent technological advancements in spatially resolved multiplexed imaging at …
View article: Pass-Efficient Algorithms for Graph Spectral Clustering (Student Abstract)
Pass-Efficient Algorithms for Graph Spectral Clustering (Student Abstract) Open
Graph spectral clustering is a fundamental technique in data analysis, which utilizes eigenpairs of the Laplacian matrix to partition graph vertices into clusters. However, classical spectral clustering algorithms require eigendecompositio…
View article: SpatialCells: Automated Profiling of Tumor Microenvironments with Spatially Resolved Multiplexed Single-Cell Data
SpatialCells: Automated Profiling of Tumor Microenvironments with Spatially Resolved Multiplexed Single-Cell Data Open
Background Cancer is a complex cellular ecosystem where malignant cells coexist and interact with immune, stromal, and other cells within the tumor microenvironment. Recent technological advancements in spatially resolved multiplexed imagi…
View article: 1273 Effect of systemic immunosuppression timing on overall survival among immune checkpoint inhibitor recipients
1273 Effect of systemic immunosuppression timing on overall survival among immune checkpoint inhibitor recipients Open
Background High-dose systemic immunosuppression (ISP) is associated with poorer survival outcomes in cancer patients treated with immune checkpoint inhibitors (ICIs).1–3 However, the effect of ISP timing on survival is not well-studied. Th…
View article: 554 Clinical outcomes of patients treated with immune checkpoint inhibitor therapy for early-stage melanoma recurrence: a retrospective cohort study
554 Clinical outcomes of patients treated with immune checkpoint inhibitor therapy for early-stage melanoma recurrence: a retrospective cohort study Open
Background Melanoma mortality has steadily decreased since the introduction of immune checkpoint inhibitors (ICIs) to manage advanced-stage disease (stage III/IV).1 Although ICIs have prolonged survival, this therapeutic class is associate…