Miklós H. Bosits
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View article: Diastereomer salt crystallization: Comprehensive process modeling and DoE-driven comparison of custom-coded and user-friendly simulators
Diastereomer salt crystallization: Comprehensive process modeling and DoE-driven comparison of custom-coded and user-friendly simulators Open
Process modeling is gaining attention in the pharmaceutical industry due to the promise of exploring the design space with less experimentation. However, the associated numerical apparatus can be prohibitive for many, undermining the attai…
View article: Population Balance Modeling of Diastereomeric Salt Resolution
Population Balance Modeling of Diastereomeric Salt Resolution Open
Diastereomeric salt crystallization is a classical, widely applicable chiral resolution technique, which enables the separation of the enantiomers of both racemate and conglomerate-forming compounds. A resolution method for racemic pregaba…
View article: CCDC 2215531: Experimental Crystal Structure Determination
CCDC 2215531: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Design of diastereomeric salt resolution<i>via</i>multicomponent system characterization: a case study with hydrate formation
Design of diastereomeric salt resolution<i>via</i>multicomponent system characterization: a case study with hydrate formation Open
Design of a chiral resolution process with thermodynamic control.
View article: New Discoveries in Enantiomeric Separation of Racemic Tofisopam
New Discoveries in Enantiomeric Separation of Racemic Tofisopam Open
Resolution process of tofisopam has been re-evaluated now based on our new investigations. Originally, it was carried out in the water-chloroform system, where the intermediate salt of high diastereomeric excess was described as ( R )- TOF…