Bo Yuan
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Author Swipe
View article: Tube-bearing experience of patients with biliary and pancreatic diseases outside the hospital: based on qualitative study
Tube-bearing experience of patients with biliary and pancreatic diseases outside the hospital: based on qualitative study Open
View article: Sex hormones and 14 autoimmune diseases: The causal relationship from a bidirectional 2-sample Mendelian randomization study
Sex hormones and 14 autoimmune diseases: The causal relationship from a bidirectional 2-sample Mendelian randomization study Open
Numerous observational studies have suggested links between sex hormones and various autoimmune diseases (ADs). However, the causality of these associations remains uncertain. This study employs Mendelian randomization (MR) analysis to inv…
View article: Effects of immune checkpoint inhibitors on the pulmonary circulation in lung cancer patients
Effects of immune checkpoint inhibitors on the pulmonary circulation in lung cancer patients Open
Immune checkpoint inhibitors (ICIs) are effective anti‐tumor agents, but new immune‐related side effects (irAEs) are emerging. This retrospective cohort study investigated 461 lung cancer patients treated with ICIs over 2 years, analyzing …
View article: Patient journey and Quality of Life for Patients with Idiopathic Pulmonary Fibrosis (IPFLife) in China: a sequential exploratory mixed methods research protocol
Patient journey and Quality of Life for Patients with Idiopathic Pulmonary Fibrosis (IPFLife) in China: a sequential exploratory mixed methods research protocol Open
Introduction Idiopathic pulmonary fibrosis (IPF) is a rare, chronic and progressive lung disease with a significant impact on patients’ quality of life. While much research has focused on disease mechanisms and treatment efficacy, limited …
View article: Impact Factors for Trajectories of Medication and Healthy Lifestyle Adherence in Young Adults With Hypertension: A Mixed Methods Study
Impact Factors for Trajectories of Medication and Healthy Lifestyle Adherence in Young Adults With Hypertension: A Mixed Methods Study Open
Treatment adherence is a cornerstone of effective hypertension management. However, the dynamic patterns of adherence and their influencing factors among young Chinese adults with hypertension remain insufficiently understood. This study a…
View article: Amorphous encapsulation engineering to overcome SMSI constraints in Pt@a-Nb <sub>2</sub> O <sub>5</sub> catalysts for CO oxidation
Amorphous encapsulation engineering to overcome SMSI constraints in Pt@a-Nb <sub>2</sub> O <sub>5</sub> catalysts for CO oxidation Open
View article: Identification of genes associated with liver ischemia-reperfusion injury after liver transplantation by WGCNA and PPI network analyses
Identification of genes associated with liver ischemia-reperfusion injury after liver transplantation by WGCNA and PPI network analyses Open
Liver transplantation is the only effective treatment for end-stage liver disease. The success of transplantation largely relies on liver ischemia/reperfusion injury (LIRI). However, the pathogenesis of LIRI remains unclear. In this study,…
View article: The Effect of the swnR Gene on Swainsonine Biosynthesis in Alternaria oxytropis OW7.8, an Endophytic Fungus of Oxytropis glabra
The Effect of the swnR Gene on Swainsonine Biosynthesis in Alternaria oxytropis OW7.8, an Endophytic Fungus of Oxytropis glabra Open
The swnR gene was cloned in the endophytic fungus Alternaria oxytropis OW 7.8 isolated from Oxytropis glabra, and the gene knockout mutant ΔswnR was first constructed in this study. Compared with A. oxytropis OW 7.8, the ΔswnR exhibited di…
View article: SF3B4 regulates proliferation and apoptosis in hepatocellular carcinoma via alternative splicing and interaction with TRIM28 and SETD5
SF3B4 regulates proliferation and apoptosis in hepatocellular carcinoma via alternative splicing and interaction with TRIM28 and SETD5 Open
View article: The Effects of P5CR Gene Function of Endophytic Fungus Alternaria oxytropis OW7.8 on Swainsonine Biosynthesis
The Effects of P5CR Gene Function of Endophytic Fungus Alternaria oxytropis OW7.8 on Swainsonine Biosynthesis Open
Locoweeds, including Oxytropis and Astragalus species, are globally recognized as plants containing swainsonine (SW), a neurotoxic alkaloid that induces neurological dysfunction and growth inhibition in livestock. SW is produced by endophy…
View article: Preventive treatment of tripdiolide ameliorates kidney injury in diabetic mice by modulating the Nrf2/NF-κB pathway
Preventive treatment of tripdiolide ameliorates kidney injury in diabetic mice by modulating the Nrf2/NF-κB pathway Open
Introduction Although tripdiolide has demonstrated a protective role in lupus nephritis, its potential therapeutic and preventive effects on diabetic kidney injury remain inconclusive. Methods In this study, a diabetes mice model was used …
View article: Prognostic significance and immune correlation analysis of HMOX1 in pan-cancer
Prognostic significance and immune correlation analysis of HMOX1 in pan-cancer Open
Background Heme oxygenase 1 (HMOX1), known for its anti-inflammatory properties, is crucial for iron homeostasis, antioxidation, and apoptosis prevention. However, its role in various malignancies is not well understood. This research aime…
View article: Risk factor analysis of plastic bronchitis among 126 children with macrolide-resistant Mycoplasma pneumoniae pneumonia with mutations at the A2063G site after bronchoscopy examination: a nomogram prediction model
Risk factor analysis of plastic bronchitis among 126 children with macrolide-resistant Mycoplasma pneumoniae pneumonia with mutations at the A2063G site after bronchoscopy examination: a nomogram prediction model Open
Objective To determine the risk factors for plastic bronchitis (PB) in children diagnosed with macrolide-resistant Mycoplasma pneumoniae (MRMP) pneumonia associated with the A2064G variant. Methods The clinical data of 126 children diagnos…
View article: Exploring the underlying molecular connections: a bioinformatics approach to link melanoma and Parkinson’s disease
Exploring the underlying molecular connections: a bioinformatics approach to link melanoma and Parkinson’s disease Open
Introduction Melanoma, a highly aggressive form of skin cancer, and Parkinson’s disease (PD), a progressive neurodegenerative disorder, have been epidemiologically linked, showing a positive association that suggests a shared etiology. Thi…
View article: Efficacy of microwave ablation <i>vs</i> laparoscopic hepatectomy for primary small liver cancer: A comparative study
Efficacy of microwave ablation <i>vs</i> laparoscopic hepatectomy for primary small liver cancer: A comparative study Open
BACKGROUND In-depth comparative investigations in terms of clinical efficacies of liver tumor microwave ablation (MWA) and laparoscopic hepatectomy (LH), which are both important treatment modalities for liver neoplasms, have been limited …
View article: Identification of the citrus GRF gene family and its expression in fruit peel thickening mediated by gibberellin
Identification of the citrus GRF gene family and its expression in fruit peel thickening mediated by gibberellin Open
View article: General commentary: GQIcombi application to subdue glioma via differentiation therapy
General commentary: GQIcombi application to subdue glioma via differentiation therapy Open
View article: Identification of the citrus GRF gene family and its expression in fruit peel thickening mediated by gibberellin
Identification of the citrus GRF gene family and its expression in fruit peel thickening mediated by gibberellin Open
Background Growth-regulating factors (GRFs) play a crucial role in plant growth and development, particularly in cell division and expansion. Citrus fruit cracking, a prevalent issue, adversely impacts both yield and fruit quality. Gibbere…
View article: Identify liver fibrosis associated hub genes using integrated bioinformatics analysis
Identify liver fibrosis associated hub genes using integrated bioinformatics analysis Open
Cirrhosis is defined as diffuse liver fibrosis (LF) caused by various chronic liver diseases and characterized by excessive deposition of extracellular matrix in liver tissue. However, the molecular mechanism of cirrhosis has not been well…
View article: A pH responsive nanocomposite for combination sonodynamic‐immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway
A pH responsive nanocomposite for combination sonodynamic‐immunotherapy with ferroptosis and calcium ion overload via SLC7A11/ACSL4/LPCAT3 pathway Open
Sonodynamic therapy offers a non‐invasive approach to induce the death of tumor cells. By harnessing ultrasound waves in tandem with sonosensitizers, this method produces reactive oxygen species (ROS) that inflict oxidative damage upon tum…
View article: MFAP2 induces epithelial-mesenchymal transformation of osteosarcoma cells by activating the Notch1 pathway
MFAP2 induces epithelial-mesenchymal transformation of osteosarcoma cells by activating the Notch1 pathway Open
Our study revealed that MFAP2 was an upstream regulator of the Notch1 signaling pathway to promote EMT in OS. These findings suggested MFAP2 as a potential OS therapy target.
View article: Identify Liver Fibrosis Associated Hub Genes Using Integrated Bioinformatics Analysis
Identify Liver Fibrosis Associated Hub Genes Using Integrated Bioinformatics Analysis Open
Background. Cirrhosis is defined as diffuse liver fibrosis (LF) caused by various chronic liver diseases and characterized by excessive deposition of extracellular matrix in liver tissue. However, the molecular mechanism of cirrhosis has n…
View article: Unveiling Potential Shared Mechanisms between Melanoma and Parkinson's Disease Through Bioinformatics Analysis
Unveiling Potential Shared Mechanisms between Melanoma and Parkinson's Disease Through Bioinformatics Analysis Open
View article: Risk factors influencing postoperative outcome of arthroscopic rotator cuff repair and construction of a nomogram prediction model
Risk factors influencing postoperative outcome of arthroscopic rotator cuff repair and construction of a nomogram prediction model Open
The presence of a frozen shoulder, large rotator cuff tear, increased intraoperative rivet use, diabetes, and traumatic tear elevate the risk of suboptimal outcomes following ARCR. Conversely, having a higher preoperative University of Cal…
View article: In Situ Synthesis of Ru/TiO<sub>2−</sub><i><sub>x</sub></i>@TiCN Ternary Heterojunctions for Enhanced Sonodynamic and Nanocatalytic Cancer Therapy
In Situ Synthesis of Ru/TiO<sub>2−</sub><i><sub>x</sub></i>@TiCN Ternary Heterojunctions for Enhanced Sonodynamic and Nanocatalytic Cancer Therapy Open
Albeit nanozymes‐based tumor catalytic therapy (NCT) relies on endogenous chemical reactions that could achieve tumor microenvironment (TME)‐specialized reactive oxygen species (ROS) production, the unsatisfactory catalytic activity of nan…
View article: The role of kidney function in the association between pro- inflammatory diet and cognitive impairment: NHANES from 2011 - 2014
The role of kidney function in the association between pro- inflammatory diet and cognitive impairment: NHANES from 2011 - 2014 Open
Aims : It has been well known that the higher inflammation levels are associated with the higher risk of cognitive impairment. Therefore, a high pro-inflammation diet may increase the risk of cognitive impairment by inducing the body’s inf…
View article: Ferroptosis regulator NOS2 is closely associated with the prognosis and cell malignant behaviors of hepatoblastoma: a bioinformatic and in vitro study
Ferroptosis regulator NOS2 is closely associated with the prognosis and cell malignant behaviors of hepatoblastoma: a bioinformatic and in vitro study Open
Background Hepatoblastoma (HB) is the most common liver tumor in children with easy metastasis. The emergence of ferroptosis as a novel form of cell death has gained increased attention in various human cancers. However, the roles of ferro…
View article: Spatial distribution and core community of diazotrophs in Biological soil crusts and subsoils in temperate semi-arid and arid deserts of China
Spatial distribution and core community of diazotrophs in Biological soil crusts and subsoils in temperate semi-arid and arid deserts of China Open
Introduction Biological soil crusts (BSCs) are distributed in arid and semiarid regions, and they function as important microhabitats for nitrogen fixation. The diazotroph community is critical for nitrogen fixation in BSCs and their subso…
View article: The Fibrotic Effects of LINC00663 in Human Hepatic Stellate LX-2 Cells and in Bile Duct-Ligated Cholestasis Mice Are Mediated through the Splicing Factor 2-Fibronectin
The Fibrotic Effects of LINC00663 in Human Hepatic Stellate LX-2 Cells and in Bile Duct-Ligated Cholestasis Mice Are Mediated through the Splicing Factor 2-Fibronectin Open
Hepatic fibrosis can develop into cirrhosis or even cancer without active therapy at an early stage. Long non-coding RNAs (lncRNAs) have been shown to be involved in the regulation of a wide variety of important biological processes. Howev…
View article: The effect of metformin usage on survival outcomes for hepatocellular carcinoma patients with type 2 diabetes mellitus after curative therapy
The effect of metformin usage on survival outcomes for hepatocellular carcinoma patients with type 2 diabetes mellitus after curative therapy Open
Objective Metformin has attracted more attention from researchers for its newly discovered antitumor effects. A meta-analysis was performed to reveal the efficacy of metformin on overall survival (OS) and recurrence-free survival (RFS) for…