Bowang Chen
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View article: Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study
Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study Open
Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We soug…
View article: [Retracted] Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer
[Retracted] Tumor‑released lncRNA H19 promotes gefitinib resistance via packaging into exosomes in non‑small cell lung cancer Open
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that certain of the TEM microscopic data featured in Fig. 3C on p. 3443, the RIP assay data in Fig. 4A and the western blot data in …
View article: Long-term exposure to ozone and incidence of lung cancer in China: data based on a national population cohort (ChinaHEART)
Long-term exposure to ozone and incidence of lung cancer in China: data based on a national population cohort (ChinaHEART) Open
Long-term exposure to ambient O3 is associated with a substantially higher risk of lung cancer. Further studies are needed to explore its pathogenic mechanisms, as well as to evaluate measures for exposure protection or harm mitigation at …
View article: Using eQTL Mendelian randomization and transcriptomic analysis to identify the relationship between ion channel genes and intracranial aneurysmal subarachnoid hemorrhage
Using eQTL Mendelian randomization and transcriptomic analysis to identify the relationship between ion channel genes and intracranial aneurysmal subarachnoid hemorrhage Open
Aneurysmal subarachnoid hemorrhage (aSAH) is a complex condition associated with high disability and mortality rates, leading to poor clinical outcomes. Previous observational studies have suggested a link between ion channel genes and aSA…
View article: Pan-cancer analysis reveals TRA16 as a master regulator of human carcinogenesis
Pan-cancer analysis reveals TRA16 as a master regulator of human carcinogenesis Open
Introduction The nuclear receptor TR4 binding protein, TRA16, has been implicated in lung carcinogenesis; however, its broader role across diverse human cancers remains poorly understood. Understanding TRA16’s involvement in cancer biology…
View article: Area-level socioeconomic inequalities in mortality in China: a nationwide cohort study based on the ChinaHEART project
Area-level socioeconomic inequalities in mortality in China: a nationwide cohort study based on the ChinaHEART project Open
For the Chinese translation of the abstract see Supplementary Materials section.
View article: Association of long-term exposure to ozone with cardiovascular mortality and its metabolic mediators: evidence from a nationwide, population-based, prospective cohort study
Association of long-term exposure to ozone with cardiovascular mortality and its metabolic mediators: evidence from a nationwide, population-based, prospective cohort study Open
This study was supported by the CAMS Innovation Fund for Medical Science (2021-1-I2M-011), the CAMS Innovation Fund for Medical Science (CIFMS, 2022-I2M-C&T-A-010), the National High Level Hospital Clinical Research Funding (2022-GSP-GG-4)…
View article: A machine learning model for early candidemia prediction in the intensive care unit: Clinical application
A machine learning model for early candidemia prediction in the intensive care unit: Clinical application Open
Candidemia often poses a diagnostic challenge due to the lack of specific clinical features, and delayed antifungal therapy can significantly increase mortality rates, particularly in the intensive care unit (ICU). This study aims to devel…
View article: Genome-wide analysis identifies novel susceptibility loci for heart failure and nonischemic cardiomyopathy subtype
Genome-wide analysis identifies novel susceptibility loci for heart failure and nonischemic cardiomyopathy subtype Open
Heart failure (HF) is a serious cardiovascular condition resulting from abnormalities in multiple biological processes that affects over 64 million people worldwide. Here, we report a meta-analysis of genome-wide analysis for all-cause HF …
View article: Association and its population heterogeneities between low-density lipoprotein cholesterol and all-cause and cardiovascular mortality: A population-based cohort study
Association and its population heterogeneities between low-density lipoprotein cholesterol and all-cause and cardiovascular mortality: A population-based cohort study Open
Background: The association and its population heterogeneities between low-density lipoprotein cholesterol (LDL-C) and all-cause and cardiovascular mortality remain unknown. We aimed to examine the dose-dependent associations of LDL-C leve…
View article: Twins and Their Risks of Cancer as Children, Teenagers or Young Adults: Updated Meta-Analysis and Retrospective Swedish Cohort Study
Twins and Their Risks of Cancer as Children, Teenagers or Young Adults: Updated Meta-Analysis and Retrospective Swedish Cohort Study Open
We investigated whether an observed reduction in overall childhood cancer risk (<15 years of age) in twins has been sustained, and how this extends into young adulthood. We searched for English language publications reporting childhood can…
View article: A machine learning model for early candidemia prediction in the intensive care unit: Clinical application
A machine learning model for early candidemia prediction in the intensive care unit: Clinical application Open
Candidemia often poses a diagnostic challenge due to the lack of specific clinical features, and delayed antifungal therapy can significantly increase mortality rates, particularly in the intensive care unit (ICU). This study aims to devel…
View article: Deciphering complex antibiotic resistance patterns in Helicobacter pylori through whole genome sequencing and machine learning
Deciphering complex antibiotic resistance patterns in Helicobacter pylori through whole genome sequencing and machine learning Open
Introduction Helicobacter pylori (H.pylori, Hp) affects billions of people worldwide. However, the emerging resistance of Hp to antibiotics challenges the effectiveness of current treatments. Investigating the genotype-phenotype connection…
View article: Associations between Chinese visceral adiposity index and risks of all‐cause and cause‐specific mortality: A population‐based cohort study
Associations between Chinese visceral adiposity index and risks of all‐cause and cause‐specific mortality: A population‐based cohort study Open
Aim To determine the associations between the Chinese visceral adiposity index (CVAI) and the risks of all‐cause and cause‐specific mortality. Materials and Methods A total of 3 916 214 Chinese adults were enrolled in a nationwide populati…
View article: Associations of remnant cholesterol with cardiovascular and cancer mortality in a nationwide cohort
Associations of remnant cholesterol with cardiovascular and cancer mortality in a nationwide cohort Open
The health significance of triglyceride-rich lipoproteins, also known as remnant cholesterol, has been increasingly recognized. However, evidence of their associations with cause-specific mortality in the general population was previously …
View article: Association of Leisure-Time Physical Activity and Mortality Risk in High Cardiovascular Risk Population with and without Left Ventricular Hypertrophy
Association of Leisure-Time Physical Activity and Mortality Risk in High Cardiovascular Risk Population with and without Left Ventricular Hypertrophy Open
The association between higher LTPA and lower mortality risk was not modified by LVH in high cardiovascular risk population. However, the presence of LVH altered this association in females regarding the all-cause mortality risk.
View article: Influence of Socioeconomic Gender Inequality on Sex Disparities in Prevention and Outcome of Cardiovascular Disease: Data From a Nationwide Population Cohort in China
Influence of Socioeconomic Gender Inequality on Sex Disparities in Prevention and Outcome of Cardiovascular Disease: Data From a Nationwide Population Cohort in China Open
Background Knowledge gaps remain in how gender‐related socioeconomic inequality affects sex disparities in cardiovascular diseases (CVD) prevention and outcome. Methods and Results Based on a nationwide population cohort, we enrolled 3 737…
View article: Associations of long-term fine particulate matter exposure with all-cause and cause-specific mortality: results from the ChinaHEART project
Associations of long-term fine particulate matter exposure with all-cause and cause-specific mortality: results from the ChinaHEART project Open
The Chinese Academy of Medical Sciences Innovation Fund for Medical Science, the National High Level Hospital Clinical Research Funding, the Ministry of Finance of China and National Health Commission of China, the 111 Project from the Min…
View article: Association of high-density lipoprotein cholesterol with all-cause and cause-specific mortality in a Chinese population of 3.3 million adults: a prospective cohort study
Association of high-density lipoprotein cholesterol with all-cause and cause-specific mortality in a Chinese population of 3.3 million adults: a prospective cohort study Open
The CAMS Innovation Fund for Medical Science (2021-1-I2M-011), the National High Level Hospital Clinical Research Funding (2022-GSP-GG-4), the Ministry of Finance of China and National Health Commission of China, and the 111 Project from t…
View article: A novel scatterplot-based method to detect copy number variation (CNV)
A novel scatterplot-based method to detect copy number variation (CNV) Open
Objective: Most methods to detect copy number variation (CNV) have high false positive rates, especially for small CNVs and in real-life samples from clinical studies. In this study, we explored a novel scatterplot-based method to detect C…
View article: Supplementary Tables S1-S3 from A Comprehensive Meta-analysis of Case–Control Association Studies to Evaluate Polymorphisms Associated with the Risk of Differentiated Thyroid Carcinoma
Supplementary Tables S1-S3 from A Comprehensive Meta-analysis of Case–Control Association Studies to Evaluate Polymorphisms Associated with the Risk of Differentiated Thyroid Carcinoma Open
Table S1. Comparison between results from literature and results from the present GWAS for all the SNPs extracted from literature. Table S2. Data published in literature where only one genetic model (either dominant or recessive) was repor…
View article: Supplementary Tables S1-S3 from A Comprehensive Meta-analysis of Case–Control Association Studies to Evaluate Polymorphisms Associated with the Risk of Differentiated Thyroid Carcinoma
Supplementary Tables S1-S3 from A Comprehensive Meta-analysis of Case–Control Association Studies to Evaluate Polymorphisms Associated with the Risk of Differentiated Thyroid Carcinoma Open
Table S1. Comparison between results from literature and results from the present GWAS for all the SNPs extracted from literature. Table S2. Data published in literature where only one genetic model (either dominant or recessive) was repor…
View article: Data from A Comprehensive Meta-analysis of Case–Control Association Studies to Evaluate Polymorphisms Associated with the Risk of Differentiated Thyroid Carcinoma
Data from A Comprehensive Meta-analysis of Case–Control Association Studies to Evaluate Polymorphisms Associated with the Risk of Differentiated Thyroid Carcinoma Open
Background: Linkage analyses and association studies suggested that inherited genetic variations play a role in the development of differentiated thyroid carcinoma (DTC).Methods: We combined the results from a genome-wide association study…
View article: Supplementary Table 1 from Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers
Supplementary Table 1 from Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in <i>BRCA1</i> and <i>BRCA2</i> Mutation Carriers Open
Supplementary Table 1. The 3,248 SNPs included in the study