Bei Wang
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View article: Generalized modeling of carbon film deposition growth via hybrid MD/MC simulations with machine-learning potentials
Generalized modeling of carbon film deposition growth via hybrid MD/MC simulations with machine-learning potentials Open
Theoretical investigations into the controlled growth of carbon films are essential for guiding the experimental fabrication of carbon-based devices. However, accurately simulating the deposition process remains a significant challenge. In…
View article: A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer
A combined enteric neuron-gastric tumor organoid reveals metabolic vulnerabilities in gastric cancer Open
The discrepancy between organoid and immortalized cell line cultures for cancer target discovery remains unclear. Here, our multi-tiered clustered regularly interspaced short palindromic repeats (CRISPR) screens reveal in vivo-relevant met…
View article: A comprehensive in silico and invitro analysis revealed the diagnostic, prognostic and therapeutic potential of GNAI family genes in colon adenocarcinoma (COAD)
A comprehensive in silico and invitro analysis revealed the diagnostic, prognostic and therapeutic potential of GNAI family genes in colon adenocarcinoma (COAD) Open
INTRODUCTION: Guanine nucleotide-binding protein alpha inhibiting activity polypeptides (GNAI1, GNAI2, and GNAI3) play critical roles in cell cycle regulation, intracellular signaling, and immune modulation. However, their contribution to …
View article: Glycyrrhiza Polysaccharide-Adjuvanted Liposomal Vaccine Potentiates Tumor Immunotherapy through Lymph Node-Targeted Modulation of the DC-T Cell Axis
Glycyrrhiza Polysaccharide-Adjuvanted Liposomal Vaccine Potentiates Tumor Immunotherapy through Lymph Node-Targeted Modulation of the DC-T Cell Axis Open
Background A key challenge in cancer immunotherapy is that tumor vaccines formulated with conventional aluminum adjuvants often fail to elicit potent cellular immunity and sustained antitumor responses. Glycyrrhizae polysaccharides (NGUP),…
View article: Generation of Maillard reaction-derived flavour compounds in coffee analogues by an extrusion-based solid model system
Generation of Maillard reaction-derived flavour compounds in coffee analogues by an extrusion-based solid model system Open
A solid food matrix (SFM) model system was established to replicate dry food processing environments and investigate how precursors and reaction parameters influence coffee flavour generation through Maillard reaction (MR). The model consi…
View article: A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy
A Self‐Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple‐Negative Breast Cancer Therapy Open
As a multifunctional extracellular protein, connective tissue growth factor (CTGF/CCN2) is significantly associated with the progression and prognosis of triple‐negative breast cancer (TNBC). However, current blockade therapies targeting C…
View article: VISLIX: An XAI Framework for Validating Vision Models with Slice Discovery and Analysis
VISLIX: An XAI Framework for Validating Vision Models with Slice Discovery and Analysis Open
Real-world machine learning models require rigorous evaluation before deployment, especially in safety-critical domains like autonomous driving and surveillance. The evaluation of machine learning models often focuses on data slices, which…
View article: Evaluating the Chinese versions of delirium assessment scales: a diagnostic systematic review
Evaluating the Chinese versions of delirium assessment scales: a diagnostic systematic review Open
The research on the Chinese adaptation of the delirium scale in China is relatively abundant and of acceptable quality. Taking into account factors of methodological quality and diagnostic accuracy, Chinese-adapted delirium assessment scal…
View article: Research on Automatic Attitude Control Technology of Six-Degree-of-Freedom Displacement Compensation for Full-Scale Aircraft Static Test
Research on Automatic Attitude Control Technology of Six-Degree-of-Freedom Displacement Compensation for Full-Scale Aircraft Static Test Open
A novel closed-loop control principle was proposed for precisely controlling the attitude of full-scale aircraft during static test under large deformation. The test system was developed by integrating a displacement acquisition system, an…
View article: Construction of a nomogram-based risk prediction model for depressive symptoms in middle-aged and young breast cancer patients
Construction of a nomogram-based risk prediction model for depressive symptoms in middle-aged and young breast cancer patients Open
BACKGROUND Breast cancer (BC) is the second most common malignancy globally. Young and middle-aged patients face more pressures from diagnosis, treatment, costs, and psychological issues like self-image concerns, social barriers, and profe…
View article: Characterization of volatile compounds in mozzarella cheeses made from bovine and buffalo milk by different aroma extraction and identification methods
Characterization of volatile compounds in mozzarella cheeses made from bovine and buffalo milk by different aroma extraction and identification methods Open
High-moisture mozzarella cheese is particularly popular because of its freshness and milky flavor; however, the difference in aroma compound composition between high-moisture mozzarella cheese made from bovine (BOC) and buffalo milk (BUC) …
View article: Current carbon policies and emerging emission control technologies in the dairy supply chain
Current carbon policies and emerging emission control technologies in the dairy supply chain Open
Addressing the dynamic changes in the carbon footprint (CF) of the dairy industry to meet the diverse demands of different countries and achieve the global net-zero emission target presents a significant challenge. This study integrates a …
View article: Extraction-dependent structural diversity of white kidney bean cotyledon polysaccharides determines their fermentability and prebiotic potential in the elderly gut microbiota
Extraction-dependent structural diversity of white kidney bean cotyledon polysaccharides determines their fermentability and prebiotic potential in the elderly gut microbiota Open
View article: Dual ferroptosis induction in N2-TANs and TNBC cells via FTH1 targeting: A therapeutic strategy for triple-negative breast cancer
Dual ferroptosis induction in N2-TANs and TNBC cells via FTH1 targeting: A therapeutic strategy for triple-negative breast cancer Open
Tumor-associated neutrophils (TANs) play a critical role in the progression and prognosis of triple-negative breast cancer (TNBC), with N2-type TANs known for their pro-tumor characteristics. This study introduces CT-1, a derivative of cry…
View article: Mutation in CDC42 Gene Set as a Response Biomarker for Immune Checkpoint Inhibitor Therapy
Mutation in CDC42 Gene Set as a Response Biomarker for Immune Checkpoint Inhibitor Therapy Open
Background Immune checkpoint inhibitors (ICIs) have achieved great success; however, a subset of patients exhibits no response. Consequently, there is a critical need for reliable predictive biomarkers. Our focus is on CDC42, which stimula…
View article: Effect of Whey Protein Changes on Milk Flavor and Sensory Characteristics During Heating
Effect of Whey Protein Changes on Milk Flavor and Sensory Characteristics During Heating Open
The flavor of dairy products crucially affects consumer purchase preference. Although the flavor and sensory perception of milk can be influenced by heat treatment during processing, the exact mechanism remains unclear. Therefore, this stu…
View article: Construction of a nomogram risk prediction model for depressive symptoms in elderly breast cancer patients
Construction of a nomogram risk prediction model for depressive symptoms in elderly breast cancer patients Open
View article: Research trends and hotspots of the applications of single-cell RNA sequencing in cardiovascular diseases: a bibliometric and visualized study
Research trends and hotspots of the applications of single-cell RNA sequencing in cardiovascular diseases: a bibliometric and visualized study Open
Background: Cardiovascular diseases (CVDs) are the leading causes of death globally. The use of single-cell RNA sequencing (scRNA-seq) in CVDs has gained significant attention in recent years, and there is a growing body of literature on t…
View article: Intracellular osteopontin potentiates the immunosuppressive activity of mesenchymal stromal cells
Intracellular osteopontin potentiates the immunosuppressive activity of mesenchymal stromal cells Open
Our findings demonstrated that iOPN expression modulation in MSCs is a novel strategy to improve MSC-based immunotherapy.
View article: Discovery of oxazine-linked pyrimidine as an inhibitor of breast cancer growth and metastasis by abrogating NF-κB activation
Discovery of oxazine-linked pyrimidine as an inhibitor of breast cancer growth and metastasis by abrogating NF-κB activation Open
Introduction Nuclear factor kappa (NF-κB) plays a key role in cancer cell proliferation; thus, small molecule inhibitors of NF-κB activity can effectively inhibit breast cancer (BC) progression. We have previously reported oxazine and pipe…
View article: Transcriptomic and Physiological Analysis Reveals the Possible Mechanism of Inhibiting Strawberry Aroma Changes by Ultrasound after Harvest
Transcriptomic and Physiological Analysis Reveals the Possible Mechanism of Inhibiting Strawberry Aroma Changes by Ultrasound after Harvest Open
The volatile compounds in strawberries play a significant role in the formation of strawberry aroma. However, these compounds undergo continual changes during storage, resulting in a decline in quality. In this study, a total of 67 volatil…
View article: Sensory and chemical characterization of chestnuts processed in different methods using instrumental analyses and the Check-all-that-apply method
Sensory and chemical characterization of chestnuts processed in different methods using instrumental analyses and the Check-all-that-apply method Open
Chestnuts are known for their unique sensory characteristics and nutritional value. However, the changes in their sensory attributes after processing remain unclear. This study used instrumental analysis and sensory evaluation combined wit…
View article: Identification of aroma-active compounds in milk by 2-dimensional gas chromatography-olfactometry-time-of-flight mass spectrometry combined with check-all-that-apply questions
Identification of aroma-active compounds in milk by 2-dimensional gas chromatography-olfactometry-time-of-flight mass spectrometry combined with check-all-that-apply questions Open
Understanding consumers' sensory preferences for dairy products is essential. This study employed sensory analysis and instrumental techniques to analyze the flavor of pasteurized milk and UHT milk. There were 6 milk samples with similar f…
View article: Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage
Deficiency of UCHL1 results in insufficient decidualization accompanied by impaired dNK modulation and eventually miscarriage Open
Background Miscarriage is a frustrating complication of pregnancy that is common among women of reproductive age. Insufficient decidualization which not only impairs embryo implantation but disturbs fetomaternal immune-tolerance, has been …
View article: Correction: Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses
Correction: Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses Open
[This corrects the article DOI: 10.1371/journal.ppat.1003231.].
View article: Evolution of hotspots and research trends in agricultural mulch film research: a bibliometric review
Evolution of hotspots and research trends in agricultural mulch film research: a bibliometric review Open
Agricultural mulch film (AMF) can increase the soil temperature, reduce the evaporation of water and soil erosion, control the number of weeds and pests, and improve the yield and quality of crops. However, the environmental pollution caus…
View article: Research Trends and Hotspots of the Applications of Single-cell RNA Sequencing in Cardiovascular Diseases: A Bibliometric and Visualized Study
Research Trends and Hotspots of the Applications of Single-cell RNA Sequencing in Cardiovascular Diseases: A Bibliometric and Visualized Study Open
Background: Cardiovascular diseases (CVDs) are the leading causes of death globally. The use of single-cell RNA sequencing (scRNA-seq) in CVDs has gained significant attention in recent years, and there is a growing body of literature on t…
View article: Physiochemical properties, volatile compounds and consumer acceptance of novel ultra-high temperature milk during storage
Physiochemical properties, volatile compounds and consumer acceptance of novel ultra-high temperature milk during storage Open
Ultra-high temperature (UHT) treatment, achieved through direct heating (D-UHT) and indirect heating (ID-UHT), imparts a long shelf-life to milk, allowing for non-refrigerated distribution. This study investigates the impact of a novel D-U…
View article: The noteworthy mechanical difference and diverse substrate damage of coatings via molecular dynamics
The noteworthy mechanical difference and diverse substrate damage of coatings via molecular dynamics Open
For previous studies have neglected the effect of coating thickness and crystal plane on materials deformation during machining, this work is to investigate how coating thickness affect materials deformation with distinct crystal orientati…
View article: Compounding engineered mesenchymal stem cell-derived exosomes: A potential rescue strategy for retinal degeneration
Compounding engineered mesenchymal stem cell-derived exosomes: A potential rescue strategy for retinal degeneration Open
The prevalence of retinal degenerative diseases, including age-related macular degeneration and retinitis pigmentosa, has been increasing globally and is linked to the aging population and improved life expectancy. These diseases are chara…