Boxuan Zhou
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View article: Unveiling Lipid Metabolism-related Gene PTGDS: A Tumor Suppressor in Lung Adenocarcinoma with Therapeutic Potential
Unveiling Lipid Metabolism-related Gene PTGDS: A Tumor Suppressor in Lung Adenocarcinoma with Therapeutic Potential Open
Background Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related mortality worldwide. Although the lipid metabolism-associated gene PTGDS has been implicated in tumorigenesis, its functional significance and regulatory mecha…
View article: Quercetin: A Natural Ally in Combating Breast Cancer
Quercetin: A Natural Ally in Combating Breast Cancer Open
Breast cancer is one of the most common cancers among women worldwide, exhibiting notably high incidence and mortality rates. Despite its high fatality, a comprehensive study that mechanism and treatment of herbal medicines has not yet bee…
View article: Bioinformatics analysis to identify environmental endocrine chemicals that target endometriosis genes
Bioinformatics analysis to identify environmental endocrine chemicals that target endometriosis genes Open
Endometriosis (EMS) significantly impacts women's health and is influenced by genetic factors and environmental endocrine-disrupting chemicals (EDCs), which interfere with hormonal balance. Using the Gene Expression Omnibus database, we id…
View article: The Relationship between Age of Onset, Cellular Functional Proteins and Social Cognition in First-Episode Drug-Naïve Schizophrenia
The Relationship between Age of Onset, Cellular Functional Proteins and Social Cognition in First-Episode Drug-Naïve Schizophrenia Open
View article: Electrically functionalized body surface for deep-tissue bioelectrical recording
Electrically functionalized body surface for deep-tissue bioelectrical recording Open
Directly probing deep tissue activities from body surfaces offers a noninvasive approach to monitoring essential physiological processes1-3. However, this method is technically challenged by rapid signal attenuation toward the body surface…
View article: Innovative Dual mRNA-Lipid Nanoparticle Therapy Targeting CRHBP and CFHR3 for Enhanced Treatment of Hepatocellular Carcinoma
Innovative Dual mRNA-Lipid Nanoparticle Therapy Targeting CRHBP and CFHR3 for Enhanced Treatment of Hepatocellular Carcinoma Open
Our study proposes a dual-targeted therapeutic strategy for HCC, which may represent a promising treatment approach.
View article: Nomogram predicting overall and cancer specific prognosis for poorly differentiated lung adenocarcinoma after resection based on SEER cohort analysis
Nomogram predicting overall and cancer specific prognosis for poorly differentiated lung adenocarcinoma after resection based on SEER cohort analysis Open
View article: A risk score based on polyamine metabolism and chemotherapy‐related genes predicts prognosis and immune cells infiltration of lung adenocarcinoma
A risk score based on polyamine metabolism and chemotherapy‐related genes predicts prognosis and immune cells infiltration of lung adenocarcinoma Open
We aimed to explore whether the genes associated with both platinum‐based therapy and polyamine metabolism could predict the prognosis of LUAD. We searched for the differential expression genes (DEGs) associated with platinum‐based therapy…
View article: Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array
Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array Open
Nonlinear optical processing of ambient natural light is highly desired for computational imaging and sensing. Strong optical nonlinear response under weak broadband incoherent light is essential for this purpose. By merging 2D transparent…
View article: Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array
Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array Open
Nonlinear optical processing of ambient natural light is highly desired for computational imaging and sensing. Strong optical nonlinear response under weak broadband incoherent light is essential for this purpose. By merging 2D transparent…
View article: Enhanced CT-based radiomics model to predict natural killer cell infiltration and clinical prognosis in non-small cell lung cancer
Enhanced CT-based radiomics model to predict natural killer cell infiltration and clinical prognosis in non-small cell lung cancer Open
Background Natural killer (NK) cells are crucial for tumor prognosis; however, their role in non-small-cell lung cancer (NSCLC) remains unclear. The current detection methods for NSCLC are inefficient and costly. Therefore, radiomics repre…
View article: FSTL3 is associated with prognosis and immune cell infiltration in lung adenocarcinoma
FSTL3 is associated with prognosis and immune cell infiltration in lung adenocarcinoma Open
View article: A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: a multi-dataset study and cytological validation
A risk score model based on lipid metabolism-related genes could predict response to immunotherapy and prognosis of lung adenocarcinoma: a multi-dataset study and cytological validation Open
Background Lipid metabolism is a key factor in tumorigenesis and drug resistance, and models related to lipid metabolism have shown potential to predict survival and curative effects of adjuvant therapy in various cancers. However, the rel…
View article: Spleen tyrosine kinase facilitates the progression of papillary thyroid cancer regulated by the hsa_circ_0006417/<scp>miR</scp>‐377‐3p axis
Spleen tyrosine kinase facilitates the progression of papillary thyroid cancer regulated by the hsa_circ_0006417/<span>miR</span>‐377‐3p axis Open
Papillary thyroid cancer (PTC) is a prevalent malignancy worldwide. Spleen tyrosine kinase (SYK) is a crucial enzyme that participates in various biological processes, including cancer progression. This study aims to uncover the biological…
View article: Prognostic and immune correlation analysis of mitochondrial autophagy and aging-related genes in lung adenocarcinoma
Prognostic and immune correlation analysis of mitochondrial autophagy and aging-related genes in lung adenocarcinoma Open
View article: Correction: CREBZF mRNA nanoparticles suppress breast cancer progression through a positive feedback loop boosted by circPAPD4
Correction: CREBZF mRNA nanoparticles suppress breast cancer progression through a positive feedback loop boosted by circPAPD4 Open
View article: Outcomes and prognosis of non-small cell lung cancer patients who underwent curable surgery: a protocol for a real-world, retrospective, population-based and nationwide Chinese National Lung Cancer Cohort (CNLCC) study
Outcomes and prognosis of non-small cell lung cancer patients who underwent curable surgery: a protocol for a real-world, retrospective, population-based and nationwide Chinese National Lung Cancer Cohort (CNLCC) study Open
Introduction Surgery is one of the main approaches for the comprehensive treatment of early and locally advanced non-small cell lung cancer (NSCLC). This study conducts a nationwide multicentre study to explore factors that could influence…
View article: CREBZF mRNA nanoparticles suppress breast cancer progression through a positive feedback loop boosted by circPAPD4
CREBZF mRNA nanoparticles suppress breast cancer progression through a positive feedback loop boosted by circPAPD4 Open
Background Breast cancer (BC) negatively impacts the health of women worldwide. Circular RNAs (circRNAs) are a group of endogenous RNAs considered essential regulatory factor in BC tumorigenesis and progression. However, the underlying mol…
View article: Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array
Broadband nonlinear modulation of incoherent light using a transparent optoelectronic neuron array Open
Nonlinear optical processing of ambient natural light is highly desired in computational imaging and sensing applications. A strong optical nonlinear response that can work under weak broadband incoherent light is essential for this purpos…
View article: Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma
Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma Open
Ferroptosis is a newly characterized form of iron-dependent non-apoptotic cell death, which is closely associated with cancer progression. However, the functions and mechanisms in regulation of escaping from ferroptosis during hepatocellul…
View article: Nanoparticles Mediated circROBO1 Silencing to Inhibit Hepatocellular Carcinoma Progression by Modulating miR-130a-5p/CCNT2 Axis
Nanoparticles Mediated circROBO1 Silencing to Inhibit Hepatocellular Carcinoma Progression by Modulating miR-130a-5p/CCNT2 Axis Open
Our findings firstly demonstrate that circROBO1 overexpression promotes HCC progression by regulating miR-130a-5p/CCNT2 axis, which may serve as an effective nanotherapeutic target for HCC treatment.
View article: Tumor Cell‐Intrinsic CD96 Mediates Chemoresistance and Cancer Stemness by Regulating Mitochondrial Fatty Acid β‐Oxidation (Adv. Sci. 7/2023)
Tumor Cell‐Intrinsic CD96 Mediates Chemoresistance and Cancer Stemness by Regulating Mitochondrial Fatty Acid β‐Oxidation (Adv. Sci. 7/2023) Open
Immunotherapy Immunotherapy using immune checkpoint inhibitors has revolutionized anticancer treatment. In article number 2202956, Qiyi Zhao and co‐workers discover CD96, a novel immune checkpoint protein, expressed in cancer cell exhibit …
View article: Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-𝜅B-IL-6 axis of tumor-associated macrophages
Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-𝜅B-IL-6 axis of tumor-associated macrophages Open
View article: Signatures of Chiral Superconductivity in Chiral Molecule Intercalated Tantalum Disulfide
Signatures of Chiral Superconductivity in Chiral Molecule Intercalated Tantalum Disulfide Open
Chiral superconductors, a unique class of unconventional superconductors in which the complex superconducting order parameter winds clockwise or counter-clockwise in the momentum space, represent a topologically non-trivial system with dir…
View article: Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation
Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation Open
Emerging evidence shows that the biomechanical environment is required to support cancer stem cells (CSCs), which play a crucial role in drug resistance. However, how mechanotransduction signals regulate CSCs and its clinical significance …
View article: Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma
Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma Open
Ferroptosis is a newly characterized form of iron-dependent non-apoptotic cell death, which is closely associated with cancer progression. However, the functions and mechanisms in regulation of escaping from ferroptosis during hepatocellul…
View article: Additional file 1 of Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-????B-IL-6 axis of tumor-associated macrophages
Additional file 1 of Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-????B-IL-6 axis of tumor-associated macrophages Open
Additional file 1: Fig. S1. Analysis of the expression and character of cSERPINE2 in breast cancercells. Fig. S2. cSERPINE2 reshaped the immune microenvironment of breast cancer. Fig. S3 Tumor exosomal cSERPINE2 targeted macrophages to pro…
View article: Tumor Cell‐Intrinsic CD96 Mediates Chemoresistance and Cancer Stemness by Regulating Mitochondrial Fatty Acid β‐Oxidation
Tumor Cell‐Intrinsic CD96 Mediates Chemoresistance and Cancer Stemness by Regulating Mitochondrial Fatty Acid β‐Oxidation Open
Targeting CD96 that originates in immune cells has shown potential for cancer therapy. However, the role of intrinsic CD96 in solid tumor cells remains unknown. Here, it is found that CD96 is frequently expressed in tumor cells from clinic…
View article: <scp>RASAL3</scp> predicts overall survival and <scp>CD8</scp>+ T lymphocyte infiltration in lung adenocarcinoma
<span>RASAL3</span> predicts overall survival and <span>CD8</span>+ T lymphocyte infiltration in lung adenocarcinoma Open
RAS‐activating protein‐like 3 (RASAL3) is a synaptic Ras GTPase‐activating protein (SynGAP) and a potential novel biomarker of CD8+ T cell infiltration in lung adenocarcinoma (LUAD). This study explored RASAL3 expression in LUAD, the progn…
View article: GBE1 Is an Independent Prognostic Marker and Associated With CD163+ Tumor-Associated Macrophage Infiltration in Lung Adenocarcinoma
GBE1 Is an Independent Prognostic Marker and Associated With CD163+ Tumor-Associated Macrophage Infiltration in Lung Adenocarcinoma Open
Glycogen branching enzyme (GBE1) is a critical gene that participates in regulating glycogen metabolism. However, the correlations between GBE1 expression and the prognosis and tumor-associated macrophages in lung adenocarcinoma (LUAD) als…