Boyan Fang
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View article: Cortical dynamics and network alterations in Parkinson’s disease with mild cognitive impairment: TMS-EEG study of the posterior parietal cortex
Cortical dynamics and network alterations in Parkinson’s disease with mild cognitive impairment: TMS-EEG study of the posterior parietal cortex Open
Individuals with mild cognitive impairment (MCI) in Parkinson's disease (PD) are significantly susceptible to developing dementia. Investigating cortical dynamics within the posterior parietal cortex (PPC) may elucidate the mechanisms unde…
IL-1β+ lung-resident macrophages mediate endothelial dysfunction and acute lung injury in sepsis through immune-metabolic crosstalk Open
Sepsis-induced acute lung injury (ALI) involves a complex interplay between immune cells and the pulmonary endothelium. However, the molecular regulators that coordinate this interaction remain poorly defined. In a murine sepsis model, we …
View article: Disruption of low-frequency narrowband EEG microstate networks in Parkinson’s disease with mild cognitive impairment
Disruption of low-frequency narrowband EEG microstate networks in Parkinson’s disease with mild cognitive impairment Open
This study identified unique abnormalities in narrowband microstate dynamics within neural networks of individuals with PD-MCI, revealing promising electrophysiological markers for the early detection and longitudinal monitoring of cogniti…
View article: Enhancing Attention Network Spatiotemporal Dynamics for Motor Rehabilitation in Parkinson's Disease
Enhancing Attention Network Spatiotemporal Dynamics for Motor Rehabilitation in Parkinson's Disease Open
Optimizing resource allocation for Parkinson's disease (PD) motor rehabilitation necessitates identifying biomarkers of responsiveness and dynamic neuroplasticity signatures underlying efficacy. A cohort study of 52 early-stage PD patients…
View article: Rehabilitation Response in Tremor‐ and Non‐Tremor‐Dominant Parkinson Disease: A Task‐fMRI Study
Rehabilitation Response in Tremor‐ and Non‐Tremor‐Dominant Parkinson Disease: A Task‐fMRI Study Open
Background Tremor‐dominant (TD) and nontremor‐dominant (NTD) Parkinson's disease (PD) showed different responses to rehabilitation. However, the neural mechanism behind this remains unclear. Methods This cohort study explores changes in mo…
Exploring the application and challenges of fNIRS technology in early detection of Parkinson’s disease Open
Background Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that significantly benefits from early diagnosis for effective disease management and intervention. Despite advancements in medical technology, there remains a c…
Functional and structural gradients reveal atypical hierarchical organization of Parkinson's disease Open
Parkinson's disease (PD) patients exhibit deficits in primary sensorimotor and higher‐order executive functions. The gradient reflects the functional spectrum in sensorimotor‐associated areas of the brain. We aimed to determine whether the…
View article: Human subcortical pathways automatically detect collision trajectory without attention and awareness
Human subcortical pathways automatically detect collision trajectory without attention and awareness Open
Detecting imminent collisions is essential for survival. Here, we used high-resolution fMRI at 7 Tesla to investigate the role of attention and consciousness for detecting collision trajectory in human subcortical pathways. Healthy partici…
View article: Intermittent theta-burst stimulation combined with physical therapy as an optimal rehabilitation in Parkinson’s disease: study protocol for a randomised, double-blind, controlled trial
Intermittent theta-burst stimulation combined with physical therapy as an optimal rehabilitation in Parkinson’s disease: study protocol for a randomised, double-blind, controlled trial Open
Background First-line rehabilitative strategies to improve motor deficits are based on functional training (physical or occupational therapy), which has been demonstrated to facilitate neural reorganisation. Accumulating evidence suggests …
Cortico–subcortical spatiotemporal dynamics in Parkinson’s disease can be modulated by transcranial alternating current stimulation Open
Objective: We investigated changes in cortico–subcortical spatiotemporal dynamics to explore the treatment mechanisms of transcranial alternating current stimulation (tACS) in patients with Parkinson’s disease (PD). Methods: Resting-state …
View article: Multimodal biofeedback for Parkinson’s disease motor and nonmotor symptoms
Multimodal biofeedback for Parkinson’s disease motor and nonmotor symptoms Open
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor retardation, myotonia, quiescent tremor, and postural gait abnormality, as well as nonmotor symptoms such as anxiety and depression. Biofeedback improves motor…
Longitudinal cognitive changes in patients with early Parkinson's disease and neuropsychiatric symptoms Open
Aims In this study, we aimed to investigate the effect of neuropsychiatric symptoms (NPS) on the rate of cognitive decline for both global cognition and specific cognitive domains in a cohort of patients from the Parkinson's Progression Ma…
View article: Human subcortical pathways automatically detect collision trajectory without attention and awareness
Human subcortical pathways automatically detect collision trajectory without attention and awareness Open
Detecting imminent collisions is essential for our survival and is likely supported by evolutionarily conserved mechanisms in the brain. Using high-resolution 7T fMRI, we investigated subcortical pathways for detecting collision trajectori…
View article: Altered Neurovascular Coupling for Multidisciplinary Intensive Rehabilitation in Parkinson's Disease
Altered Neurovascular Coupling for Multidisciplinary Intensive Rehabilitation in Parkinson's Disease Open
Effective rehabilitation in Parkinson's disease (PD) is related to brain reorganization with restoration of cortico–subcortical networks and compensation of frontoparietal networks; however, further neural rehabilitation evidence from a mu…
Predictive Value of Exercise Blood Pressure Changes for Orthostatic Hypotension in Patients With Parkinson’s Disease Open
This study has identified predictive factors for OH development in patients with PD. CPET could be used as a complementary examination to identify patients at a high risk of OH.
Lacunes may worsen cognition but not motor function in Parkinson's disease Open
Background As one of the imaging markers of cerebral small vessel disease, lacunes has received little attention. The objective of this study was to investigate the associations of lacunes, cognition and motor function in patients with Par…
View article: Circular RNAs in Parkinson’s Disease: Reliable Biological markers and targets for Rehabilitation
Circular RNAs in Parkinson’s Disease: Reliable Biological markers and targets for Rehabilitation Open
In clinical practice, the underlying pathogenesis of Parkinson’s disease (PD) remains unknown. Circular RNAs (circRNAs) have good biological properties and can be used as biological marker. Rehabilitation as a third treatment alongside dru…
Clinical Manifestation, Auxiliary Examination Features, and Prognosis of GFAP Autoimmunity: A Chinese Cohort Study Open
Objective: This paper reports the clinical manifestation and auxiliary examination features of 15 Chinese patients with glial fibrillary acidic protein (GFAP) autoimmunity. Methods: From June 2016 to December 2019, patients suspected to ha…
View article: Characterizing cortical responses to short-term multidisciplinary intensive rehabilitation treatment in patients with Parkinson’s disease: A transcranial magnetic stimulation and electroencephalography study
Characterizing cortical responses to short-term multidisciplinary intensive rehabilitation treatment in patients with Parkinson’s disease: A transcranial magnetic stimulation and electroencephalography study Open
Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is a powerful non-invasive tool for qualifying the neurophysiological effects of interventions by recording TMS-induced cortical activation with high temporal …
View article: Effects of High Cervical Spinal Cord Stimulation on Gait Disturbance and Dysarthropneumophonia in Parkinson’s Disease and Parkinson Variant of Multiple System Atrophy: A Case Series
Effects of High Cervical Spinal Cord Stimulation on Gait Disturbance and Dysarthropneumophonia in Parkinson’s Disease and Parkinson Variant of Multiple System Atrophy: A Case Series Open
High cervical spinal cord stimulation (HCSCS) was found to have therapeutic effects on Parkinsonian gait disturbance. However, the results were inconsistent and confounded with symptoms of pain. This study aimed to reveal the gait and dysa…
Association Between Mitochondrial Function and Rehabilitation of Parkinson's Disease: Revealed by Exosomal mRNA and lncRNA Expression Profiles Open
Rehabilitation has been proposed as a valid measure complementary to the management of Parkinson's disease (PD). However, the mechanism underlying is not clear yet. The differential expressions of exosomal messenger RNA (mRNA) and long non…
Quality of life predicts rehabilitation prognosis in Parkinson's disease patients Open
Background Rehabilitation has been reported to improve the quality of life (QoL) of patients with Parkinson's disease (PD). Nevertheless, not all patients are satisfied with rehabilitation outcomes and could achieve a significant improveme…