Boyang Jason Wu
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View article: Reprogramming the immunologically cold landscape of prostate cancer through MAOA inhibition
Reprogramming the immunologically cold landscape of prostate cancer through MAOA inhibition Open
Prostate cancer (PC) is notoriously known for exhibiting an immunologically cold phenotype in the tumor immune microenvironment (TIME), leading to the need for interventions to enhance immunotherapy efficacy. Recent findings by Zhao et al.…
View article: Application of Drug Retention Enema Combined with Deep Hyperthermia in the Rehabilitation of Radiation Proctitis in Patients with Cervical Cancer
Application of Drug Retention Enema Combined with Deep Hyperthermia in the Rehabilitation of Radiation Proctitis in Patients with Cervical Cancer Open
Objective: To investigate the efficacy of drug retention enema combined with deep hyperthermia in the treatment of radiation proctitis in patients with cervical cancer. Methods: A randomized controlled study was conducted, selecting 60 pat…
View article: PSMA-Targeted 2-Deoxyglucose-Based Dendrimer Nanomedicine for the Treatment of Prostate Cancer
PSMA-Targeted 2-Deoxyglucose-Based Dendrimer Nanomedicine for the Treatment of Prostate Cancer Open
Prostate cancer (PC) is the fifth leading cause of cancer-related deaths among men worldwide. Prostate-specific membrane antigen (PSMA), a molecular target of PC, is clinically used for the treatment and diagnosis of PC using radioligand a…
View article: Analysis of The Effect of Bundled Nursing Intervention on Lung Cancer Patients with a High Risk of PICC-Related Thrombosis
Analysis of The Effect of Bundled Nursing Intervention on Lung Cancer Patients with a High Risk of PICC-Related Thrombosis Open
Objective: To explore the effect of bundled nursing intervention on lung cancer patients with a high risk of PICC-related thrombosis. Methods: Eighty-six PICC patients were selected and randomly divided into a control group and an observat…
View article: Inhibition of cyclin-dependent kinase 7 mitigates doxorubicin cardiotoxicity and enhances anticancer efficacy
Inhibition of cyclin-dependent kinase 7 mitigates doxorubicin cardiotoxicity and enhances anticancer efficacy Open
Aims The anthracycline family of anticancer agents such as doxorubicin (DOX) can induce apoptotic death of cardiomyocytes and cause cardiotoxicity. We previously reported that DOX-induced apoptosis is accompanied by cardiomyocyte cell cycl…
View article: Whole-Exome Sequencing (WES) Reveals Novel Sex-Specific Gene Variants in Non-Alcoholic Steatohepatitis (MASH)
Whole-Exome Sequencing (WES) Reveals Novel Sex-Specific Gene Variants in Non-Alcoholic Steatohepatitis (MASH) Open
Non-alcoholic steatohepatitis (NASH, also known as MASH) is a severe form of non-alcoholic fatty liver disease (NAFLD, also known as MASLD). Emerging data indicate that the progression of the disease to MASH is higher in postmenopausal wom…
View article: Stromal-derived MAOB promotes prostate cancer growth and progression
Stromal-derived MAOB promotes prostate cancer growth and progression Open
Prostate cancer (PC) develops in a microenvironment where the stromal cells modulate adjacent tumor growth and progression. Here, we demonstrated elevated levels of monoamine oxidase B (MAOB), a mitochondrial enzyme that degrades biogenic …
View article: PSMA-targeted dendrimer as an efficient anticancer drug delivery vehicle for prostate cancer
PSMA-targeted dendrimer as an efficient anticancer drug delivery vehicle for prostate cancer Open
We present PD-CTT1298 nanoplatform as a versatile approach for selective systemic delivery of high payloads of potent chemotherapeutics to PSMA (+) prostate cancer, where dose related systemic side-effects are a major concern.
View article: Discovery of 2-deoxy glucose surfaced mixed layer dendrimer: a smart neuron targeted systemic drug delivery system for brain diseases
Discovery of 2-deoxy glucose surfaced mixed layer dendrimer: a smart neuron targeted systemic drug delivery system for brain diseases Open
The availability of non-invasive drug delivery systems capable of efficiently transporting bioactive molecules across the blood-brain barrier to specific cells at the injury site in the brain is currently limited. Delivering drugs to neuro…
View article: Nitrogen-assisted laser-based powder bed fusion fabricated NiTi with high hardness and low modulus
Nitrogen-assisted laser-based powder bed fusion fabricated NiTi with high hardness and low modulus Open
The role of the protective gases in laser-based powder bed fusion (L-PBF) is mainly to avoid the oxidation of metals during the melting and solidification process. However, the gaseous environment can also interact with metals, and result …
View article: Simultaneously focusing electromagnetic and acoustic waves by double-physical-fields null medium
Simultaneously focusing electromagnetic and acoustic waves by double-physical-fields null medium Open
A novel double-physical-fields lens that can simultaneously focus acoustic and electromagnetic waves into a given region is designed based on double-physical-fields null medium, which can be realized by metal plates with subwavelength sepa…
View article: Fast Semantic Segmentation of Remote Sensing Images Using a Network That Integrates Global and Local Information
Fast Semantic Segmentation of Remote Sensing Images Using a Network That Integrates Global and Local Information Open
Efficient processing of ultra-high-resolution images is increasingly sought after with the continuous advancement of photography and sensor technology. However, the semantic segmentation of remote sensing images lacks a satisfactory soluti…
View article: A Multi-Step Fusion Network for Semantic Segmentation of High-Resolution Aerial Images
A Multi-Step Fusion Network for Semantic Segmentation of High-Resolution Aerial Images Open
The demand for semantic segmentation of ultra-high-resolution remote sensing images is becoming increasingly stronger in various fields, posing a great challenge with concern to the accuracy requirement. Most of the existing methods proces…
View article: Figures S1-S5 from R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc
Figures S1-S5 from R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc Open
Figure S1: R1 does not affect contact inhibition during prostate cancer cell proliferation; Figure S2: R1 does not affect cell apoptosis in prostate cancer cells under both steady state and dynamic conditions; Figure S3: R1 promotes prosta…
View article: Data from R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc
Data from R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc Open
Prostate cancer is a prevalent public health problem, especially because noncutaneous advanced malignant forms significantly affect the lifespan and quality of life of men worldwide. New therapeutic targets and approaches are urgently need…
View article: Figures S1-S5 from R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc
Figures S1-S5 from R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc Open
Figure S1: R1 does not affect contact inhibition during prostate cancer cell proliferation; Figure S2: R1 does not affect cell apoptosis in prostate cancer cells under both steady state and dynamic conditions; Figure S3: R1 promotes prosta…
View article: Data from R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc
Data from R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc Open
Prostate cancer is a prevalent public health problem, especially because noncutaneous advanced malignant forms significantly affect the lifespan and quality of life of men worldwide. New therapeutic targets and approaches are urgently need…
View article: Data from Bidirectional Cross-talk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer
Data from Bidirectional Cross-talk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer Open
Androgen receptor (AR) is the primary oncogenic driver of prostate cancer, including aggressive castration-resistant prostate cancer (CRPC). The molecular mechanisms controlling AR activation in general and AR reactivation in CRPC remain e…
View article: Data from Bidirectional Cross-talk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer
Data from Bidirectional Cross-talk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer Open
Androgen receptor (AR) is the primary oncogenic driver of prostate cancer, including aggressive castration-resistant prostate cancer (CRPC). The molecular mechanisms controlling AR activation in general and AR reactivation in CRPC remain e…
View article: Supplementary Data from Bidirectional Cross-talk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer
Supplementary Data from Bidirectional Cross-talk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer Open
This file include 11 Supplementary Figures, Supplementary Materials and Methods, and Supplementary References.
View article: Supplementary Data from Bidirectional Cross-talk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer
Supplementary Data from Bidirectional Cross-talk between MAOA and AR Promotes Hormone-Dependent and Castration-Resistant Prostate Cancer Open
This file include 11 Supplementary Figures, Supplementary Materials and Methods, and Supplementary References.
View article: Monoamine oxidase A: An emerging therapeutic target in prostate cancer
Monoamine oxidase A: An emerging therapeutic target in prostate cancer Open
Monoamine oxidase A (MAOA), a mitochondrial enzyme degrading biogenic and dietary amines, has been studied in the contexts of neuropsychiatry and neurological disorders for decades, but its importance in oncology, as best exemplified in pr…
View article: Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy
Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy Open
Blockade of pyruvate influx into mitochondria increased glycolysis levels in PCa but not in non-carcinoma prostate tissue. This transient blockage sensitized PCa to both detection and radiotherapy, thus indicating that glycolytic potential…
View article: A Simple Suboptimal Moving Horizon Estimation Scheme With Guaranteed Robust Stability
A Simple Suboptimal Moving Horizon Estimation Scheme With Guaranteed Robust Stability Open
We propose a suboptimal moving horizon estimation (MHE) scheme for a general class of nonlinear systems. To this end, we consider an MHE formulation that optimizes over the trajectory of a robustly stable observer. Assuming that the observ…