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View article: Structure and function of a pair of non-competing monoclonal antibodies against Langya henipavirus attachment glycoprotein
Structure and function of a pair of non-competing monoclonal antibodies against Langya henipavirus attachment glycoprotein Open
Langya henipavirus (LayV) is a zoonotic Parahenipavirus (Para-HNV) identified in recent years, discovered via surveillance of febrile patients with recent animal exposure in eastern China. The attachment glycoprotein (G) of HNV is critical…
View article: Application of Nasal Septum Traction Combined With Continuous Suture in Septoplasty: Enhancing Surgical Efficacy and Olfactory Function
Application of Nasal Septum Traction Combined With Continuous Suture in Septoplasty: Enhancing Surgical Efficacy and Olfactory Function Open
Objective: In septoplasty, the combination of nasal septum traction and continuous nasal septum suture techniques is employed to correct the rebound area of the nasal septum after surgery, ensuring optimal surgical outcomes. Methods: In th…
View article: Prediction of new-onset atrial fibrillation in sepsis patients by machine learning: A systematic review
Prediction of new-onset atrial fibrillation in sepsis patients by machine learning: A systematic review Open
Aims New-onset atrial fibrillation (NOAF) occurs in approximately 23% of patients with sepsis and is independently associated with increased mortality. Therefore, early prediction of NOAF has significant clinical value. However, current ar…
View article: Structure and function of an unusual R452-dependent monoclonal antibody against SARS-CoV-2
Structure and function of an unusual R452-dependent monoclonal antibody against SARS-CoV-2 Open
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is still a major public health concern worldwide. Currently, SARS-CoV-2 variants have been widely used to deve…
View article: Rapid clonal expansion and somatic hypermutation contribute to the fate of SARS-CoV-2 broadly neutralizing antibodies
Rapid clonal expansion and somatic hypermutation contribute to the fate of SARS-CoV-2 broadly neutralizing antibodies Open
Several vaccines and immunization strategies, including inactivated vaccines, have proven effective in eliciting antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), providing an opportunity to characterize the …
View article: Sequential intranasal booster triggers class switching from intramuscularly primed IgG to mucosal IgA against SARS-CoV-2
Sequential intranasal booster triggers class switching from intramuscularly primed IgG to mucosal IgA against SARS-CoV-2 Open
The persistent emergence of COVID-19 variants and recurrent waves of infection worldwide underscores the urgent need for vaccines that effectively reduce viral transmission and prevent infections. Current intramuscular (IM) COVID-19 vaccin…
View article: The characterization and structural basis of a human broadly binding antibody to HBV core protein
The characterization and structural basis of a human broadly binding antibody to HBV core protein Open
Hepatitis B virus (HBV) core protein (HBc) plays a crucial role in the virus life cycle, making it an important detection marker for HBV infection and a potential target for treatment. However, several commercially available monoclonal ant…
View article: Early prediction of acute-on-chronic liver failure development in patients with diverse chronic liver diseases
Early prediction of acute-on-chronic liver failure development in patients with diverse chronic liver diseases Open
Acute-on-chronic liver failure (ACLF) is a syndrome characterized by the acute decompensation of chronic liver disease, resulting in organ failure and high short-term mortality. The progression of ACLF is dynamic and reversible in a consid…
View article: A deep learning framework for hepatocellular carcinoma diagnosis using MS1 data
A deep learning framework for hepatocellular carcinoma diagnosis using MS1 data Open
Clinical proteomics analysis is of great significance for analyzing pathological mechanisms and discovering disease-related biomarkers. Using computational methods to accurately predict disease types can effectively improve patient disease…
View article: Association between the triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular diseases in people living with human immunodeficiency virus: Evidence from a retrospectively cohort study 2005–2022
Association between the triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular diseases in people living with human immunodeficiency virus: Evidence from a retrospectively cohort study 2005–2022 Open
Introduction: The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, a novel biomarker for metabolic syndrome (MetS), has been validated in the general population as being significantly correlated with cardiovascular di…
View article: Becoming Better: When and Why Positive Status Change Induces Prosocial Behavior Versus Self-Interested Behavior
Becoming Better: When and Why Positive Status Change Induces Prosocial Behavior Versus Self-Interested Behavior Open
Prior research on status has focused primarily on the cognitive perspective, exploring the effects of status and offering a limited understanding of the impact of positive status change and its emotional mechanisms. This study draws upon t…
View article: Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection
Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection Open
Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infections. Owing to the o…
View article: Synthetically Feasible De Novo Molecular Design of Leads Based on a Reinforcement Learning Model: AI-Assisted Discovery of an Anti-IBD Lead Targeting CXCR4
Synthetically Feasible De Novo Molecular Design of Leads Based on a Reinforcement Learning Model: AI-Assisted Discovery of an Anti-IBD Lead Targeting CXCR4 Open
Artificial intelligence (AI) de novo molecular generation provides leads with novel structures for drug discovery. However, the target affinity and synthesizability of the generated molecules present critical challenges for the successful …
View article: Levels of antibodies against the monkeypox virus compared by HIV status and historical smallpox vaccinations: a serological study
Levels of antibodies against the monkeypox virus compared by HIV status and historical smallpox vaccinations: a serological study Open
Men who have sex with men and people living with HIV are disproportionately affected in the 2022 multi-country monkeypox epidemic. The smallpox vaccine can induce cross-reactive antibodies against the monkeypox virus (MPXV) and reduce the …
View article: Artificial Intelligence-Assisted Optimization of Antipigmentation Tyrosinase Inhibitors: <i>De Novo</i> Molecular Generation Based on a Low Activity Lead Compound
Artificial Intelligence-Assisted Optimization of Antipigmentation Tyrosinase Inhibitors: <i>De Novo</i> Molecular Generation Based on a Low Activity Lead Compound Open
Artificial intelligence (AI) de novo molecular generation is a highly promising strategy in the drug discovery, with deep reinforcement learning (RL) models emerging as powerful tools. This study introduces a fragment-by-fragment growth RL…
View article: MolProphet: A One-Stop, General Purpose, and AI-Based Platform for the Early Stages of Drug Discovery
MolProphet: A One-Stop, General Purpose, and AI-Based Platform for the Early Stages of Drug Discovery Open
Artificial intelligence (AI) is an effective tool to accelerate drug discovery and cut costs in discovery processes. Many successful AI applications are reported in the early stages of small molecule drug discovery. However, most of those …
View article: Early Prediction of Acute-on-Chronic Liver Failure Development in patients with diverse chronic liver diseases
Early Prediction of Acute-on-Chronic Liver Failure Development in patients with diverse chronic liver diseases Open
Background & aims: Acute-on-chronic liver failure (ACLF) is a syndrome characterized by the acute decompensation of chronic liver disease, leading to organ failures and high short-term mortality. The course of ACLF is dynamic and reversibl…
View article: MS1Former: A robust deep learning framework is used to identify nuances in LC-MS data for diagnosis of hepatocellular carcinoma
MS1Former: A robust deep learning framework is used to identify nuances in LC-MS data for diagnosis of hepatocellular carcinoma Open
Clinical proteomics analysis is of great significance for analyzing pathological mechanisms and discovering disease-related biomarkers. Using computational methods to accurately predict disease types can effectively improve patient disease…
View article: Circ-NFKB1 sponges miR-203a-5p to regulate ERBB4 expression and promotes IL-1β induced chondrocytes apoptosis
Circ-NFKB1 sponges miR-203a-5p to regulate ERBB4 expression and promotes IL-1β induced chondrocytes apoptosis Open
Background Osteoarthritis (OA) is a chronic disease of the bones and joints that commonly affects middle-aged and elderly individuals, characterized by the degeneration of articular cartilage and inflammation of the joints. The molecular m…
View article: Sustainable Vitality and Learning: The Connotation, Scale, and Heterogeneity of Dualistic Psychological Thriving at Work
Sustainable Vitality and Learning: The Connotation, Scale, and Heterogeneity of Dualistic Psychological Thriving at Work Open
Psychological thriving is crucial for the sustainable well-being and continuous growth of employees in the workplace. This study aims to explore the concept, measurement, and heterogeneity of dualistic psychological thriving at work to pro…
View article: Striking antibody evasion of SARS-CoV-2 Omicron sub-lineages BQ.1.1, XBB.1 and CH.1.1
Striking antibody evasion of SARS-CoV-2 Omicron sub-lineages BQ.1.1, XBB.1 and CH.1.1 Open
An intelligent indoor metasurface robotic is empowered on the physical layer by programmable metasurfaces and on the cyber layer by artificial-intelligence tools.
View article: Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants
Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants Open
The omicron variants of SARS-CoV-2 have substantial ability to escape infection- and vaccine-elicited antibody immunity. Here, we investigated the extent of such escape in nine convalescent patients infected with the wild-type SARS-CoV-2 d…
View article: Broadly neutralizing and protective antibodies against Omicron subvariants elicited by prototype SARS-CoV-2 infection
Broadly neutralizing and protective antibodies against Omicron subvariants elicited by prototype SARS-CoV-2 infection Open
PDB validation report of anti-SARS-CoV-2 antibody