Bozhi Wang
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View article: Therapeutic potential of T-cell receptor targeting the HLA-A*11:01-restricted KRAS<sup>G12V</sup> neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors
Therapeutic potential of T-cell receptor targeting the HLA-A*11:01-restricted KRAS<sup>G12V</sup> neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors Open
Background Public neoantigens, including KRAS, TP53, and PIK3CA mutations, which are shared across various tumor types, have demonstrated significant immunogenicity and offer great promise for cancer immunotherapy. Clinical trials targetin…
View article: Therapeutic potential of T cell receptor targeting the HLA-A*11:01-restricted KRASG12V neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors
Therapeutic potential of T cell receptor targeting the HLA-A*11:01-restricted KRASG12V neoantigen without cross-recognition of the self-antigen RAB7B in solid tumors Open
Background Public neoantigens, including KRAS, TP53, and PIK3CA mutations, which are shared across various tumor types, have demonstrated significant immunogenicity and offer great promise for cancer immunotherapy. Clinical trials targetin…
View article: Identification of novel KRASG12D neoantigen specific TCRs and a strategy to eliminate off-target recognition
Identification of novel KRASG12D neoantigen specific TCRs and a strategy to eliminate off-target recognition Open
View article: Identification of novel KRASG12D neoantigen specific TCRs and a strategy to eliminate off-target recognition
Identification of novel KRASG12D neoantigen specific TCRs and a strategy to eliminate off-target recognition Open
Background: T cell receptor (TCR)–engineered T cells targeting neoantigens originated from mutations in KRAS gene have demonstrated promising outcomes in clinical trials against solid tumors. However, the challenge lies in developing tumor…
View article: Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations
Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations Open
View article: Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T-cell receptors for cancer immunotherapy targeting hotspot driver mutations
Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T-cell receptors for cancer immunotherapy targeting hotspot driver mutations Open
Hotspot driver mutations presented by human leukocyte antigens (HLAs) can be recognized by antitumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mutations, such as PIK3CA H10…
View article: A Highly Flexible Piezoelectric Ultrasonic Sensor for Wearable Bone Density Testing
A Highly Flexible Piezoelectric Ultrasonic Sensor for Wearable Bone Density Testing Open
Driven by the loss of bone calcium, the elderly are prone to osteoporosis, and regular routine checks on bone status are necessary, which mainly rely on bone testing equipment. Therefore, wearable real-time healthcare devices have become a…
View article: CENPM upregulation by E5 oncoprotein of human papillomavirus promotes radiosensitivity in head and neck squamous cell carcinoma
CENPM upregulation by E5 oncoprotein of human papillomavirus promotes radiosensitivity in head and neck squamous cell carcinoma Open
HPV E5 enhances CENPM expression by transcription factor E2F1 in HNSCC, which results in a radiosensitive profile in cell cycle redistribution of HNSCC. Thus, HPV infection in HNSCC provides profound evidence that underscores the magnitude…
View article: HPV<sup>+</sup> HNSCC‐derived exosomal miR‐9‐5p inhibits TGF‐β signaling‐mediated fibroblast phenotypic transformation through NOX4
HPV<sup>+</sup> HNSCC‐derived exosomal miR‐9‐5p inhibits TGF‐β signaling‐mediated fibroblast phenotypic transformation through NOX4 Open
Human papillomavirus (HPV) is a significant risk factor for head and neck squamous cell carcinoma (HNSCC). HPV + HNSCC patients have a higher survival rate, which may be related to its unique tumor microenvironment. Exosomes are emerging a…
View article: Physiological and Transcriptomic Analyses Reveal Exogenous Trehalose Is Involved in the Responses of Wheat Roots to High Temperature Stress
Physiological and Transcriptomic Analyses Reveal Exogenous Trehalose Is Involved in the Responses of Wheat Roots to High Temperature Stress Open
High temperature stress seriously limits the yield and quality of wheat. Trehalose, a non-reducing disaccharide, has been shown involved in regulating plant responses to a variety of environmental stresses. This study aimed to explore the …
View article: Recent Advances on Conducting Polymers Based Nanogenerators for Energy Harvesting
Recent Advances on Conducting Polymers Based Nanogenerators for Energy Harvesting Open
With the rapid growth of numerous portable electronics, it is critical to develop high-performance, lightweight, and environmentally sustainable energy generation and power supply systems. The flexible nanogenerators, including piezoelectr…
View article: Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level
Applications and analytical tools of cell communication based on ligand-receptor interactions at single cell level Open
View article: Characteristics of B lymphocyte infiltration in HPV<sup>+</sup> head and neck squamous cell carcinoma
Characteristics of B lymphocyte infiltration in HPV<sup>+</sup> head and neck squamous cell carcinoma Open
Human papillomavirus (HPV) is an important etiological factor of head and neck squamous cell carcinoma (HNSCC). HPV + HNSCC patients usually have a better prognosis, which probably results from the higher infiltration of B lymphocytes. Thi…
View article: HRRD: a manually-curated database about the regulatory relationship between HPV and host RNA
HRRD: a manually-curated database about the regulatory relationship between HPV and host RNA Open
HPV (Human papilloma virus) is a kind of small double-stranded DNA viruses which is extremely associated with different cancers. The roles HPV plays in the host were gradually identified through the interaction between it (including its ea…
View article: Effects of Different Concentrations of Methyl Jasmonate on Fruit Quality of Citrus Huangguogan
Effects of Different Concentrations of Methyl Jasmonate on Fruit Quality of Citrus Huangguogan Open
In this study, methyl jasmonate (MeJA) was sprayed on the fruits of Huangguogan in shimian county in two different ways (whole tree spraying and fruit spraying) to study the effect of MeJA on the postharvest quality of the fruits of Huangg…
View article: Effects of Fulvic Acid on Photosynthetic Characteristics of Citrus Seedlings Under Drought Stress
Effects of Fulvic Acid on Photosynthetic Characteristics of Citrus Seedlings Under Drought Stress Open
The experimental material in the experiment was citrus seedling of Huangguogan. An experiment was conducted to study the effects of fulvic acid on photosynthetic characteristics of citrus seedlings under drought stress. Portable photosynth…
View article: Study on the accumulation of Phenols during fruit development of two Pomelos
Study on the accumulation of Phenols during fruit development of two Pomelos Open
This experiment used Huangjinmiyou and Sanhongmiyou as materials to studythe accumulation of phenolic substances during fruit developmentin different parts of pomelo fruit (exocarp, mesocarp and pulp) via Folin-Ciocalteuassay. The results …
View article: Effects of Different Leaf Area Index on Fruit Quality andproduction ofHuangguogan
Effects of Different Leaf Area Index on Fruit Quality andproduction ofHuangguogan Open
In this experiment, Citrus Huangguogan was used as the test material, and5 leaf area index (LAI) treatments were set. The fruit quality and production of each treatment were measured and analysed. With the decrease of LAI, single fruit wei…
View article: Effects of planting density on diurnal variation of microenvironment in Huangguogan orchards
Effects of planting density on diurnal variation of microenvironment in Huangguogan orchards Open
In this experiment, Huangguogan was used as the material. The effects of different planting densities on the diurnal variation of microenvironment in citrus orchard was studied, and thekey research findingsare as below. The orchard environ…
View article: Accumulation characteristics of total flavonoids in Sanhongmiyou and Huangjinmiyou
Accumulation characteristics of total flavonoids in Sanhongmiyou and Huangjinmiyou Open
The experiment was conducted to study the tendency of the change of flavonoids content in pomelo during its growth and development and the characteristics of flavonoids accumulation in different cultivars Guanximiyou. The dried samples of …
View article: Study on the color difference of Pomelo cv. Huangjinmiyou in different planting areas
Study on the color difference of Pomelo cv. Huangjinmiyou in different planting areas Open
In order to study the effect of different planting areas on the color of Pomelo cv. Huangjinmiyou fruit, Pujiang and Guang’an Pomelo cv. Huangjinmiyou were used in this experiment. Brightness, red and green deviation and blue and yellow de…
View article: Recovery of Iron from Pyrolusite Leaching Slag by a Lab-Scale Circulation Process of Oxalic Acid Leaching and Ultraviolet Irradiation
Recovery of Iron from Pyrolusite Leaching Slag by a Lab-Scale Circulation Process of Oxalic Acid Leaching and Ultraviolet Irradiation Open
Pyrolusite leaching slag is a Fe-containing slag generated from pyrolusite leaching process with SO2. Recovery of iron from the slag not only has economic benefit, but also prevents the secondary pollution to the environment. A novel lab-s…