Brad H. Li
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View article: Structure and dynamics of endogenous protein complexes in human heart tissue captured by native nanoproteomics
Structure and dynamics of endogenous protein complexes in human heart tissue captured by native nanoproteomics Open
Protein complexes are highly dynamic entities that display substantial diversity in their assembly, post-translational modifications, and non-covalent interactions, allowing them to play critical roles in various biological processes. The …
View article: Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry
Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry Open
The SARS-CoV-2 Omicron (B.1.1.529) variant possesses numerous spike (S) mutations particularly in the S receptor-binding domain (S-RBD) that significantly improve transmissibility and evasion of neutralizing antibodies. But exactly how the…
View article: <i>Rbm20</i> ablation is associated with changes in the expression of titin-interacting and metabolic proteins
<i>Rbm20</i> ablation is associated with changes in the expression of titin-interacting and metabolic proteins Open
Label-free quantitative proteomics identifies molecular correlates of dilated cardiomyopathy in rats lacking the muscle-specific splicing factor Rbm20 .
View article: Distinct core glycan and <i>O</i> -glycoform utilization of SARS-CoV-2 Omicron variant Spike protein RBD revealed by top-down mass spectrometry
Distinct core glycan and <i>O</i> -glycoform utilization of SARS-CoV-2 Omicron variant Spike protein RBD revealed by top-down mass spectrometry Open
Top-down mass spectrometry reveals O -glycoform structural changes in the SARS-CoV-2 Omicron variant. Resolving the mutations and post-translational alterations can inform strategies for designing variant-directed diagnostics and therapeut…