Brad J. Kolls
YOU?
Author Swipe
View article: Population‐based prevalence of epilepsy in Uganda: A nationwide cross‐sectional survey
Population‐based prevalence of epilepsy in Uganda: A nationwide cross‐sectional survey Open
Objective Establishing the prevalence of epilepsy in Uganda is crucial to inform interventions and public policy. We conducted a nationwide survey to determine epilepsy prevalence. Methods From January 2019 to July 2022, a door‐to‐door sur…
View article: IMPROVE Time to Anti-Coagulation Reversal for Hemorrhagic Strokes
IMPROVE Time to Anti-Coagulation Reversal for Hemorrhagic Strokes Open
Background Oral anticoagulation (OAC) is a risk factor for intracerebral hemorrhage (ICH) which is an important source of disability and mortality. OAC-associated ICH (OAC-ICH) patients have worse outcomes as compared to ICH patients not o…
View article: Experience with a hybrid recruitment approach of patient-facing web portal screening and subsequent phone and medical record review for a neurosurgical intervention trial for chronic ischemic stroke disability (PISCES III)
Experience with a hybrid recruitment approach of patient-facing web portal screening and subsequent phone and medical record review for a neurosurgical intervention trial for chronic ischemic stroke disability (PISCES III) Open
Background Recruitment of participants is the greatest risk to completion of most clinical trials, with 20–40% of trials failing to reach the targeted enrollment. This is particularly true of trials of central nervous system (CNS) therapie…
View article: Regionalization of stroke systems of care in the stroke belt states: The IMPROVE stroke care quality improvement program
Regionalization of stroke systems of care in the stroke belt states: The IMPROVE stroke care quality improvement program Open
The IMPROVE program approach was successful at improving the delivery of thrombolytic intervention across the consortium at both spoke and hub sites through collaborative efforts to operationalize guideline-based care through iterative sha…
View article: Methodological considerations in PISCES 3: a randomized, placebo-controlled study of intracerebral stem cells in subjects with disability following an ischemic stroke
Methodological considerations in PISCES 3: a randomized, placebo-controlled study of intracerebral stem cells in subjects with disability following an ischemic stroke Open
Background and hypothesis At present, there are no medical interventions proven to improve functional recovery in patients with subacute stroke. We hypothesize that the intraparenchymal administration of CTX0E03, a conditionally immortaliz…
View article: Current Practices in Stroke Systems of Care: An International Survey of Progressive Stroke System Processes
Current Practices in Stroke Systems of Care: An International Survey of Progressive Stroke System Processes Open
Background and Aims Guidelines by the AHA/ASA recommend the development of stroke systems of care yet do not provide specifics as to how this should be done. As a first step in developing a regional stroke system of care in the “Stroke Bel…
View article: Optimization of a Translational Murine Model of Closed-head Traumatic Brain Injury
Optimization of a Translational Murine Model of Closed-head Traumatic Brain Injury Open
Traumatic brain injury (TBI) from closed-head trauma is a leading cause of disability with limited effective interventions. Many TBI models impact brain parenchyma directly following craniotomy, and are limited by the fact that these force…
View article: Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke
Apixaban or Warfarin and Aspirin or Placebo After Acute Coronary Syndrome or Percutaneous Coronary Intervention in Patients With Atrial Fibrillation and Prior Stroke Open
ClinicalTrials.gov Identifier: NCT02415400.
View article: Association of time-temperature curves with outcomes in temperature management for cardiac arrest
Association of time-temperature curves with outcomes in temperature management for cardiac arrest Open
Background/Purpose Cardiac arrest is a common cause of death and neurological injury; therapeutic cooling for neuroprotection is standard of care. Despite numerous and ongoing trials targeting a specified cooling temperature for a target d…
View article: Machine Learning for Predicting Discharge Disposition After Traumatic Brain Injury
Machine Learning for Predicting Discharge Disposition After Traumatic Brain Injury Open
BACKGROUND: Current traumatic brain injury (TBI) prognostic calculators are commonly used to predict the mortality and Glasgow Outcome Scale, but these outcomes are most relevant for severe TBI. Because mild and moderate TBI rarely reaches…
View article: Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial
Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Prostate Cancer: The Primary Results of the PRONOUNCE Randomized Trial Open
Background: The relative cardiovascular safety of gonadotropin-releasing hormone (GnRH) antagonists compared with GnRH agonists in men with prostate cancer and known atherosclerotic cardiovascular disease remains controversial. Methods: In…
View article: Surgical intervention and patient factors associated with poor outcomes in patients with traumatic brain injury at a tertiary care hospital in Uganda
Surgical intervention and patient factors associated with poor outcomes in patients with traumatic brain injury at a tertiary care hospital in Uganda Open
OBJECTIVE The purpose of this study was to investigate whether neurosurgical intervention for traumatic brain injury (TBI) is associated with reduced risks of death and clinical deterioration in a low-income country with a relatively high …
View article: Prophylactic Treatment With CN-105 Improves Functional Outcomes in a Murine Model of Closed Head Injury
Prophylactic Treatment With CN-105 Improves Functional Outcomes in a Murine Model of Closed Head Injury Open
Introduction: Traumatic brain injury (TBI) has become the signature wound of recent military operations and training over the past two decades. A treatment that would protect against secondary brain injury in TBI and improve the long-term …
View article: Socioeconomic Influence on Emergency Medical Services Utilization for Acute Stroke: Think Nationally, Act Locally
Socioeconomic Influence on Emergency Medical Services Utilization for Acute Stroke: Think Nationally, Act Locally Open
Background and Purpose: Rates of emergency medical services (EMS) utilization for acute stroke remain low nationwide, despite the time-sensitive nature of the disease. Prior research suggests several demographic and social factors are asso…
View article: Cerebral Venous Thrombosis: Reviewing Pathophysiology, Diagnosis, and Treatment Strategies
Cerebral Venous Thrombosis: Reviewing Pathophysiology, Diagnosis, and Treatment Strategies Open
This review discusses cerebral venous thrombosis (CVT), including diagnosis and treatment strategies, a rare class of stroke that, if unrecognized or untreated, can have devastating effects. Thrombosis of one or many cerebral veins leads t…
View article: Stroke in Patients With Peripheral Artery Disease
Stroke in Patients With Peripheral Artery Disease Open
Background and Purpose— Predictors of stroke and transient ischemic attack (TIA) in patients with peripheral artery disease (PAD) are poorly understood. The primary aims of this analysis were to (1) determine the incidence of ischemic/hemo…
View article: Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes: Insights From the TRACER Trial
Stroke Outcomes With Vorapaxar Versus Placebo in Patients With Acute Coronary Syndromes: Insights From the TRACER Trial Open
Background Vorapaxar, a protease‐activated receptor‐1 antagonist, is approved for secondary prevention of cardiovascular events but is associated with increased intracranial hemorrhage. Methods and Results TRACER (Thrombin Receptor Antagon…
View article: Apolipoprotein E mimetic peptide CN-105 improves outcome in a murine model of SAH
Apolipoprotein E mimetic peptide CN-105 improves outcome in a murine model of SAH Open
Objective Subarachnoid haemorrhage (SAH) accounts for 3% of all strokes, and is associated with significant morbidity and mortality. There is growing evidence implicating apolipoprotein E (apoE) in mediating adaptive anti-inflammatory and …
View article: Cardiovascular adverse events in the drug‐development program of bupropion for smoking cessation: A systematic retrospective adjudication effort
Cardiovascular adverse events in the drug‐development program of bupropion for smoking cessation: A systematic retrospective adjudication effort Open
Background In 2011, the US Food and Drug Administration requested that GlaxoSmithKline perform retrospective adjudication of cardiovascular ( CV ) events reported in the bupropion drug‐development trials for smoking cessation. Hypothesis R…
View article: Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model
Neuroprotective pentapeptide CN-105 is associated with reduced sterile inflammation and improved functional outcomes in a traumatic brain injury murine model Open
At present, there are no proven pharmacological treatments demonstrated to improve long term functional outcomes following traumatic brain injury(TBI). In the setting of non-penetrating TBI, sterile brain inflammatory responses are associa…
View article: Apolipoprotein E mimetic peptide, <scp>CN</scp>‐105, improves outcomes in ischemic stroke
Apolipoprotein E mimetic peptide, <span>CN</span>‐105, improves outcomes in ischemic stroke Open
Objective At present, the absence of a pharmacological neuroprotectant represents an important unmet clinical need in the treatment of ischemic and traumatic brain injury. Recent evidence suggests that administration of apolipoprotein E mi…