Brad Kline
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View article: <sup>68</sup>Ga-FAP-2286 PET of Solid Tumors: Biodistribution, Dosimetry, and Comparison with<sup>18</sup>F-FDG
<sup>68</sup>Ga-FAP-2286 PET of Solid Tumors: Biodistribution, Dosimetry, and Comparison with<sup>18</sup>F-FDG Open
Fibroblast activation protein (FAP), expressed in the tumor microenvironment of a variety of cancers, has become a target of novel PET tracers. The purpose of this report is to evaluate the imaging characteristics of 68Ga-FAP-2286, present…
View article: Initial Experience with<sup>68</sup>Ga-FAP-2286 PET Imaging in Patients with Urothelial Cancer
Initial Experience with<sup>68</sup>Ga-FAP-2286 PET Imaging in Patients with Urothelial Cancer Open
Improved imaging modalities are needed to accurately stage patients with muscle-invasive bladder cancer (MIBC) and metastatic urothelial carcinoma. Imaging with small-molecule ligands or inhibitors of fibroblast activation protein (FAP) is…
View article: 1432 Discovery of HIO 3 a tumor-produced protein that binds the human IgG1 Fc CH3 domain and suppresses antibody dependent cellular cytotoxicity and complement dependent cytotoxicity
1432 Discovery of HIO 3 a tumor-produced protein that binds the human IgG1 Fc CH3 domain and suppresses antibody dependent cellular cytotoxicity and complement dependent cytotoxicity Open
Background Human cancers employ a number of mechanisms to evade host immune responses against novel antigens generated from aberrant over-expression, mutations and/or epigenetic alterations. Humoral immunity utilizes antibodies and immune-…
View article: Novel antibody probes for the characterization of endosialin/TEM-1
Novel antibody probes for the characterization of endosialin/TEM-1 Open
Endosialin (Tumor Endothelial Marker-1 (TEM-1), CD248) is primarily expressed on pericytes of tumor-associated microvasculature, tumor-associated stromal cells and directly on tumors of mesenchymal origin, including sarcoma and melanoma. W…