Bradley H. Collins
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View article: Transforming the logistics of liver transplantation with normothermic machine perfusion: Clinical impact versus cost
Transforming the logistics of liver transplantation with normothermic machine perfusion: Clinical impact versus cost Open
Normothermic machine perfusion (NMP) facilitates the utilization of marginal liver allografts. It remains unknown whether clinical benefits offset additional costs in the real-world setting. We performed a comparison of outcomes and hospit…
View article: Late surgical site infections among solid organ transplant recipients: an unrecognized clinical entity
Late surgical site infections among solid organ transplant recipients: an unrecognized clinical entity Open
This study identified 26 late invasive primary surgical site infection (IP-SSI) within 4–12 months of transplantation among 2073 SOT recipients at Duke University Hospital over the period 2015–2019. Thoracic organ transplants accounted for…
View article: Readmission Risk after COVID-19 Hospitalization: A Moderation Analysis by Vital Signs
Readmission Risk after COVID-19 Hospitalization: A Moderation Analysis by Vital Signs Open
Comorbid conditions, including pulmonary and cardiovascular disease, are associated with readmission risk after COVID-19 hospitalization. The normalization of vital signs within 24 hours of discharge during COVID-19 hospitalization may be …
View article: <i>Clostridioides difficile</i> Induced Rhabdomyolysis Associated With Decompensated Cirrhosis
<i>Clostridioides difficile</i> Induced Rhabdomyolysis Associated With Decompensated Cirrhosis Open
Rhabdomyolysis (RBD) occurs secondary to tissue injury, resulting in (muscle) cell lysis and release of intracellular electrolytes and proteins into circulation. An elevation in the muscle enzyme, creatine kinase (CK), is a diagnostic mark…
View article: A Historical Cohort in Kidney Transplantation: 55-Year Follow-Up of 72 HLA-Identical, Donor-Recipient Pairs
A Historical Cohort in Kidney Transplantation: 55-Year Follow-Up of 72 HLA-Identical, Donor-Recipient Pairs Open
The impact of HLA matching on graft survival has been well characterized in renal transplantation, with a higher degree of matching associated with superior graft survival. Additionally, living donor grafts are known to confer superior sur…
View article: The Legacy of Joseph A. Moylan, M.D.: “It’s About Everyone Else”
The Legacy of Joseph A. Moylan, M.D.: “It’s About Everyone Else” Open
The history of modern American surgery is marked by larger-than-life pioneers who have made transformative contributions to our field. These extraordinary individuals have been known primarily for their technical and clinical mastery, deve…
View article: Coagulation, inflammation, and CD46 transgene expression in neonatal porcine islet xenotransplantation
Coagulation, inflammation, and CD46 transgene expression in neonatal porcine islet xenotransplantation Open
Background Thrombosis is a known consequence of intraportal islet transplantation, particularly for xenogeneic islets. To define the origins of thrombosis after islet xenotransplantation and relate it to early inflammation, we examined por…
View article: Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation
Definition and Analysis of Textbook Outcome: A Novel Quality Measure in Kidney Transplantation Open
Background “Textbook outcome” (TO) is a novel composite quality measure that encompasses multiple postoperative endpoints, representing the ideal “textbook” hospitalization for complex surgical procedures. We defined TO for kidney transpla…
View article: TRANSPLANTATION, BIOENGINEERING, AND REGENERATION OF THE ENDOCRINE PANCREAS EDS: Giuseppe Orlando, Lorenzo Piemonti, Camillo Ricordi, Robert J. Stratta and Rainer W.G. Gruessner Cambridge, MA: Academic Press, 2020; Vol. 1, 865 pages, Vol. 2, 546 pages
TRANSPLANTATION, BIOENGINEERING, AND REGENERATION OF THE ENDOCRINE PANCREAS EDS: Giuseppe Orlando, Lorenzo Piemonti, Camillo Ricordi, Robert J. Stratta and Rainer W.G. Gruessner Cambridge, MA: Academic Press, 2020; Vol. 1, 865 pages, Vol. 2, 546 pages Open
View article: Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model
Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model Open
View article: Kidney transplant in the COVID era: Cautious optimism and continued vigilance
Kidney transplant in the COVID era: Cautious optimism and continued vigilance Open
The authors comment on the usefulness of a new model to advise centers on risks versus benefits of kidney transplantation during the COVID epidemic. See page 2997 for Massie et al's article.
View article: Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients
Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients Open
Significance Statement Although common desensitization strategies for patients with broad HLA sensitization permit transplantation via transient lowering of donor-specific antibodies, the B cell–response axis from germinal center activatio…
View article: Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use
Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use Open
Significance Statement Targeting plasma cells to reduce the risk of antibody-mediated rejection and decreased allograft survival due to anti-HLA donor-specific antibodies has not been explored in transplantation. After sensitizing eight rh…
View article: The role of human CD46 in early xenoislet engraftment in a dual transplant model
The role of human CD46 in early xenoislet engraftment in a dual transplant model Open
Background Membrane cofactor protein CD46 attenuates the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46 have been shown to resist hyperacute rejection. However, the in…
View article: Secondary lymphoid tissue and costimulation-blockade resistant rejection: A nonhuman primate renal transplant study
Secondary lymphoid tissue and costimulation-blockade resistant rejection: A nonhuman primate renal transplant study Open
View article: Evaluation and Active Treatment versus Active Surveillance of Localized Prostate Cancer in Renal Transplant Patients in the Era of Low and Very Low Risk Prostate Cancer
Evaluation and Active Treatment versus Active Surveillance of Localized Prostate Cancer in Renal Transplant Patients in the Era of Low and Very Low Risk Prostate Cancer Open
There are no standardized guidelines for screening and management of prostate cancer before and after transplantation. In the era of low risk prostate cancer end stage renal disease is a significant competing mortality risk factor. The rol…
View article: Early barriers to neonatal porcine islet engraftment in a dual transplant model
Early barriers to neonatal porcine islet engraftment in a dual transplant model Open
View article: Fatal <scp>SV</scp>40‐associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque
Fatal <span>SV</span>40‐associated pneumonia and nephropathy following renal allotransplantation in rhesus macaque Open
Recrudescence of latent and dormant viruses may lead to overwhelming viremia in immunosuppressed hosts. In immunocompromised hosts, Simian virus 40 ( SV 40) reactivation is known to cause nephritis and demyelinating central nervous system …
View article: Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model
Selective Targeting of High-Affinity LFA-1 Does Not Augment Costimulation Blockade in a Nonhuman Primate Renal Transplantation Model Open
View article: Trends in Usage and Outcomes for Expanded Criteria Donor Kidney Transplantation in the United States Characterized by Kidney Donor Profile Index
Trends in Usage and Outcomes for Expanded Criteria Donor Kidney Transplantation in the United States Characterized by Kidney Donor Profile Index Open
There has been increasing concern in the kidney transplant community about the declining use of expanded criteria donors (ECD) despite improvement in survival and quality of life. The recent introduction of the Kidney Donor Profile Index (…