Bradley D. Pearce
YOU?
Author Swipe
View article: Fluid Cognition Among Individuals With Systemic Lupus Erythematosus
Fluid Cognition Among Individuals With Systemic Lupus Erythematosus Open
Objective We sought to describe fluid cognition and its correlates among individuals with systemic lupus erythematosus (SLE). Methods Participants (n = 199) were recruited from a population‐based cohort for a single study visit (October 20…
View article: Physical Performance in a Diverse, <scp>Population‐Based</scp> Cohort of Individuals With Systemic Lupus Erythematosus
Physical Performance in a Diverse, <span>Population‐Based</span> Cohort of Individuals With Systemic Lupus Erythematosus Open
Objective To report the burden and correlates of poor physical performance in a diverse cohort of individuals with systemic lupus erythematosus (SLE). Methods In this single‐visit study of 446 individuals with SLE from a population‐based m…
View article: Association of infection with <i>Toxoplasma gondii</i> and <i>Toxocara</i> on cognitive function among US adults aged 60 and over, NHANES 2011–2014
Association of infection with <i>Toxoplasma gondii</i> and <i>Toxocara</i> on cognitive function among US adults aged 60 and over, NHANES 2011–2014 Open
Background Toxoplasma gondii and Toxocara are common parasites that infect humans globally. Our aim was to examine the relationship between T. gondii and Toxocara infection and cognition. Methods Multivariate logistic regression was used t…
View article: Automatic Sample Segmentation & Detection of Parkinson’s Disease Using Synthetic Staining & Deep Learning
Automatic Sample Segmentation & Detection of Parkinson’s Disease Using Synthetic Staining & Deep Learning Open
The identification of Parkinson’s Disease (PD) from post-mortem brain slices is time consuming for highly trained neuropathologists, often taking many hours per case. In this study, we demonstrate fully automatic PD detection, from single …
View article: Child Maltreatment and Inflammatory Response to Mental Stress Among Adults Who Have Survived a Myocardial Infarction
Child Maltreatment and Inflammatory Response to Mental Stress Among Adults Who Have Survived a Myocardial Infarction Open
Objective Experiences of child maltreatment are associated with cardiovascular risk and disease in adulthood; however, the mechanisms underlying these associations are poorly understood. Methods We examined associations between retrospecti…
View article: Dietary emulsifier consumption alters gene expression in the amygdala and paraventricular nucleus of the hypothalamus in mice
Dietary emulsifier consumption alters gene expression in the amygdala and paraventricular nucleus of the hypothalamus in mice Open
Dietary emulsifier consumption promotes systemic low-grade inflammation, metabolic deregulation, and possibly an anxiety-like phenotype. The latter finding suggests that dietary emulsifiers impact brain areas that modulate stress responses…
View article: Early life stress and autonomic response to acute mental stress in individuals with coronary heart disease
Early life stress and autonomic response to acute mental stress in individuals with coronary heart disease Open
Early life stress (ELS) has been associated with an increased risk of cardiovascular disease. We examined whether ELS was associated with autonomic function and stress reactivity among individuals with coronary heart disease (CHD). We incl…
View article: Noninvasive Cervical Vagal Nerve Stimulation Alters Brain Activity During Traumatic Stress in Individuals With Posttraumatic Stress Disorder
Noninvasive Cervical Vagal Nerve Stimulation Alters Brain Activity During Traumatic Stress in Individuals With Posttraumatic Stress Disorder Open
Objective Posttraumatic stress disorder (PTSD) is a disabling condition affecting a large segment of the population; however, current treatment options have limitations. New interventions that target the neurobiological alterations underly…
View article: Vaginal Microbiome Composition in Early Pregnancy and Risk of Spontaneous Preterm and Early Term Birth Among African American Women
Vaginal Microbiome Composition in Early Pregnancy and Risk of Spontaneous Preterm and Early Term Birth Among African American Women Open
Objective To evaluate the association between the early pregnancy vaginal microbiome and spontaneous preterm birth (sPTB) and early term birth (sETB) among African American women. Methods Vaginal samples collected in early pregnancy (8-14 …
View article: Toxoplasma gondii Effects on the Relationship of Kynurenine Pathway Metabolites to Acoustic Startle Latency in Schizophrenia vs. Control Subjects
Toxoplasma gondii Effects on the Relationship of Kynurenine Pathway Metabolites to Acoustic Startle Latency in Schizophrenia vs. Control Subjects Open
Background: Chronic infection with Toxoplasma gondii (TOXO) results in microcysts in the brain that are controlled by inflammatory activation and subsequent changes in the kynurenine pathway. TOXO seropositivity is associated with a height…
View article: Association of Early-Life Trauma and Risk of Adverse Cardiovascular Outcomes in Young and Middle-aged Individuals With a History of Myocardial Infarction
Association of Early-Life Trauma and Risk of Adverse Cardiovascular Outcomes in Young and Middle-aged Individuals With a History of Myocardial Infarction Open
Early-life trauma is an independent risk factor for adverse outcomes in young and middle-aged individuals with a history of MI. Neurobiological mechanisms leading to lifetime activation of systemic inflammatory cascades may be implicated.
View article: Application of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders
Application of Noninvasive Vagal Nerve Stimulation to Stress-Related Psychiatric Disorders Open
Background: Vagal Nerve Stimulation (VNS) has been shown to be efficacious for the treatment of depression, but to date, VNS devices have required surgical implantation, which has limited widespread implementation. Methods: New noninvasive…
View article: Diet, Stress and Mental Health
Diet, Stress and Mental Health Open
Introduction: There has long been an interest in the effects of diet on mental health, and the interaction of the two with stress; however, the nature of these relationships is not well understood. Although associations between diet, obesi…
View article: Glucocorticoid receptor sensitivity in early pregnancy in an African American cohort
Glucocorticoid receptor sensitivity in early pregnancy in an African American cohort Open
Problem Disruption in homeostatic feedback loops between inflammatory mediators and the hypothalamic‐pituitary‐adrenal (HPA) axis is a key mechanism linking chronic stress to inflammation and adverse health outcomes, including those occurr…
View article: Inflammatory markers are associated with psychomotor slowing in patients with schizophrenia compared to healthy controls
Inflammatory markers are associated with psychomotor slowing in patients with schizophrenia compared to healthy controls Open
Patients with schizophrenia exhibit psychomotor deficits that are associated with poor functional outcomes. One pathway that may be associated with psychomotor slowing is inflammation. Inflammatory markers have been shown to be elevated in…
View article: Confederates in the Attic
Confederates in the Attic Open
Da Costa originally described Soldier's Heart in the 19th Century as a syndrome that occurred on the battlefield in soldiers of the American Civil War. Soldier's Heart involved symptoms similar to modern day posttraumatic stress disorder (…
View article: Transcutaneous Cervical Vagal Nerve Stimulation Reduces Sympathetic Responses to Stress in Posttraumatic Stress Disorder
Transcutaneous Cervical Vagal Nerve Stimulation Reduces Sympathetic Responses to Stress in Posttraumatic Stress Disorder Open
Objective Exacerbated autonomic responses to acute stress are prevalent in posttraumatic stress disorder (PTSD). The purpose of this study was to assess the effects of transcutaneous cervical VNS (tcVNS) on autonomic responses to acute str…
View article: A pilot study for exploring blood spot anti-mullerian hormone for population-based adolescent reproductive health research
A pilot study for exploring blood spot anti-mullerian hormone for population-based adolescent reproductive health research Open
While these pilot data suggest AMH fell within normal range and our DBS methods were acceptable/feasible, the broader question of its usefulness for population reproductive health research remains unanswered. Larger, longitudinal studies a…
View article: Hypertensive disorders in pregnancy and maternal and neonatal outcomes in Haiti: the importance of surveillance and data collection
Hypertensive disorders in pregnancy and maternal and neonatal outcomes in Haiti: the importance of surveillance and data collection Open
A high prevalence of HDP was found among a cohort of Haitian mothers. HDP was associated with higher rates of adverse maternal and neonatal outcomes in HAS, which is comparable to studies of HDP conducted in high-income countries.
View article: F16. INFLAMMATORY MARKERS ARE ASSOCIATED WITH PSYCHOMOTOR SLOWING IN PATIENTS WITH SCHIZOPHRENIA COMPARED TO HEALTHY CONTROLS
F16. INFLAMMATORY MARKERS ARE ASSOCIATED WITH PSYCHOMOTOR SLOWING IN PATIENTS WITH SCHIZOPHRENIA COMPARED TO HEALTHY CONTROLS Open
Previous data have demonstrated that administration of inflammatory cytokines or their inducers leads to altered basal ganglia function associated with reduced psychomotor speed. Patients with schizophrenia (SCZ) exhibit psychomotor slowin…