Bradley E. Dubrule
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View article: Mycobacteriophage Mcgavigan Uses Noncanonical Bxb1‐Like Repressor for Heterotypic Superinfection Immunity
Mycobacteriophage Mcgavigan Uses Noncanonical Bxb1‐Like Repressor for Heterotypic Superinfection Immunity Open
Mycobacteriophage Mcgavigan could be a promising candidate for use as a preventative agent against infections with Mycobacterium avium subsp. paratuberculosis . Bioinformatic analysis of the Mcgavigan genome revealed the presence of an ope…
View article: Engineered Ubiquitin Variants Mitigate Pathogenic Bacterial Ubiquitin Ligase Function
Engineered Ubiquitin Variants Mitigate Pathogenic Bacterial Ubiquitin Ligase Function Open
During infection some pathogenic gram-negative bacteria, such as Salmonella , manipulate the host ubiquitination system through the delivery of secreted effectors known as novel E3 ubiquitin ligases (NELs). Despite the presence of NELs amo…
View article: NOD1 is super-activated through spatially-selective ubiquitination by the <i>Salmonella</i> effector SspH2
NOD1 is super-activated through spatially-selective ubiquitination by the <i>Salmonella</i> effector SspH2 Open
As part of its pathogenesis, Salmonella enterica serovar Typhimurium delivers effector proteins into host cells. One effector is SspH2, a member of the novel E3 ubiquitin ligase family, interacts with, and enhances, NOD1 pro-inflammatory s…