Bradley J. Kerr
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View article: Sex-specific involvement of calcitonin gene–related peptide signaling for pain in experimental autoimmune encephalomyelitis
Sex-specific involvement of calcitonin gene–related peptide signaling for pain in experimental autoimmune encephalomyelitis Open
Introduction: Neuropathic pain (NP) is one of the most devastating and under-managed symptoms of multiple sclerosis (MS). As it stands, NP is a difficult condition to treat, as many commonly used pain therapies are ineffective. Research ha…
View article: CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation Open
Microglia – the predominant immune cells of the brain and spinal cord – perform essential functions for the development and maintenance of the central nervous system, contingent upon the regulated developmental proliferation of microglia. …
View article: A recent history of immune cell sex differences in the peripheral nervous system in persistent pain states
A recent history of immune cell sex differences in the peripheral nervous system in persistent pain states Open
Pain is entwined with inflammation, and biological sex often influences mechanisms of the immune system. Due to possible differences in inflammatory mechanisms, women are predisposed to autoimmune diseases and chronic pain. Despite sex as …
View article: Peripheral immune response and axonal degeneration in the hind paw skin of mice with experimental autoimmune encephalomyelitis
Peripheral immune response and axonal degeneration in the hind paw skin of mice with experimental autoimmune encephalomyelitis Open
View article: Plasticity of Mouse Dorsal Root Ganglion Neurons by Innate Immune Activation Is Influenced by Electrophysiological Activity
Plasticity of Mouse Dorsal Root Ganglion Neurons by Innate Immune Activation Is Influenced by Electrophysiological Activity Open
The complex relationship between inflammation, its effects on neuronal excitability and the ensuing plasticity of dorsal root ganglion (DRG) sensory neurons remains to be fully explored. In this study, we have employed a system of experime…
View article: Plasticity of mouse dorsal root ganglion neurons by innate immune activation is influenced by electrophysiological activity
Plasticity of mouse dorsal root ganglion neurons by innate immune activation is influenced by electrophysiological activity Open
Background. The intricate interplay between inflammation, its effects on neuronal excitability, and the ensuing plasticity of dorsal root ganglion (DRG) sensory neurons remains to be fully explored. In this study, we have investigated the …
View article: Regulation of Kv1.2 Redox-Sensitive Gating by the Transmembrane Lectin LMAN2
Regulation of Kv1.2 Redox-Sensitive Gating by the Transmembrane Lectin LMAN2 Open
Voltage gated potassium (Kv)1.2 channels influence excitability and action potential propagation in the nervous system. Unlike closely related Kv1 channels, Kv1.2 exhibits highly variable voltage-dependence of gating, attributed to regulat…
View article: Reducing agents facilitate membrane patch seal integrity and longevity
Reducing agents facilitate membrane patch seal integrity and longevity Open
The patch clamp method is a widely applied electrophysiological technique used to understand ion channel activity and cellular excitation. The formation of a high resistance giga-ohm seal is required to obtain high-quality recordings but c…
View article: Microglia promote remyelination independent of their role in clearing myelin debris
Microglia promote remyelination independent of their role in clearing myelin debris Open
Multiple sclerosis (MS) is an inflammatory disease characterized by myelin loss. While therapies exist to slow MS progression, no treatment currently exists for remyelination. Remyelination, linked to reduced disability in MS, relies on mi…
View article: Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia
Heightened presence of inflammatory mediators in the cerebrospinal fluid of patients with trigeminal neuralgia Open
Introduction: Trigeminal neuralgia (TN) is a chronic, debilitating facial pain disease causing stabbing pain attacks in the sensory distribution of the trigeminal nerve. The underlying pathophysiology of TN is incompletely understood, alth…
View article: Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance
Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance Open
Background Microglia regulate the response to injury and disease in the brain and spinal cord. In white matter diseases microglia may cause demyelination. However, how microglia respond and regulate demyelination is not fully understood. M…
View article: Sex differences in the inflammatory response of the mouse DRG and its connection to pain in experimental autoimmune encephalomyelitis
Sex differences in the inflammatory response of the mouse DRG and its connection to pain in experimental autoimmune encephalomyelitis Open
Multiple Sclerosis (MS) is an autoimmune disease with notable sex differences. Women are not only more likely to develop MS but are also more likely than men to experience neuropathic pain in the disease. It has been postulated that neurop…
View article: Sex differences in the inflammatory response of the mouse DRG and its connection to pain in experimental autoimmune encephalomyelitis.
Sex differences in the inflammatory response of the mouse DRG and its connection to pain in experimental autoimmune encephalomyelitis. Open
Multiple Sclerosis (MS) is an autoimmune disease with notable sex differences. Women are not only more likely to develop MS but are also more likely than men to experience neuropathic pain in the disease. It has been postulated that neurop…
View article: Sex differences in the inflammatory response of the mouse DRG and its connection to pain in Multiple Sclerosis
Sex differences in the inflammatory response of the mouse DRG and its connection to pain in Multiple Sclerosis Open
Multiple Sclerosis (MS) is an autoimmune disease with notable sex differences. Women are not only more likely to develop MS but are also more likely than men to experience neuropathic pain in the disease. It has been postulated that neurop…
View article: TNFα in MS and Its Animal Models: Implications for Chronic Pain in the Disease
TNFα in MS and Its Animal Models: Implications for Chronic Pain in the Disease Open
Multiple Sclerosis (MS) is a debilitating autoimmune disease often accompanied by severe chronic pain. The most common type of pain in MS, called neuropathic pain, arises from disease processes affecting the peripheral and central nervous …
View article: Review for "Dose‐dependent effect of myelin oligodendrocyte glycoprotein on visual function and optic nerve damage in experimental autoimmune encephalomyelitis"
Review for "Dose‐dependent effect of myelin oligodendrocyte glycoprotein on visual function and optic nerve damage in experimental autoimmune encephalomyelitis" Open
View article: Multiple Sclerosis and the Endogenous Opioid System
Multiple Sclerosis and the Endogenous Opioid System Open
Multiple sclerosis (MS) is an autoimmune disease characterized by chronic inflammation, neuronal degeneration and demyelinating lesions within the central nervous system. The mechanisms that underlie the pathogenesis and progression of MS …
View article: Review for "Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology in female mice with experimental autoimmune encephalomyelitis"
Review for "Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology in female mice with experimental autoimmune encephalomyelitis" Open
View article: Review for "Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology in female mice with experimental autoimmune encephalomyelitis"
Review for "Timing of treatment with an endogenous opioid alters immune response and spinal cord pathology in female mice with experimental autoimmune encephalomyelitis" Open
View article: Immune cell populations in the broiler ileum exhibit differential cytokine profiles in response to lipid source and peroxidation
Immune cell populations in the broiler ileum exhibit differential cytokine profiles in response to lipid source and peroxidation Open
Used restaurant oil offers a sustainable and affordable energy source in broiler diets but variable lipid composition and the presence of harmful peroxidation products may alter intestinal immunity. The objective of this study was to evalu…
View article: Microglia Diversity in Health and Multiple Sclerosis
Microglia Diversity in Health and Multiple Sclerosis Open
Multiple Sclerosis (MS) is a neurodegenerative disease characterized by multiple focal lesions, ongoing demyelination and, for most people, a lack of remyelination. MS lesions are enriched with monocyte-derived macrophages and brain-reside…
View article: Endoplasmic reticulum stress in the dorsal root ganglia regulates large‐conductance potassium channels and contributes to pain in a model of multiple sclerosis
Endoplasmic reticulum stress in the dorsal root ganglia regulates large‐conductance potassium channels and contributes to pain in a model of multiple sclerosis Open
Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) stress in dorsal root ganglia (DRG) contributes to pain hypers…
View article: ER stress-mediated BK dysfunction in the DRG underlies pain in a model of multiple sclerosis
ER stress-mediated BK dysfunction in the DRG underlies pain in a model of multiple sclerosis Open
Neuropathic pain is a common symptom of multiple sclerosis (MS) and current treatment options are ineffective. In this study, we investigated whether endoplasmic reticulum (ER) stress in dorsal root ganglia (DRG) contributes to pain hypers…
View article: Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion
Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion Open
Microglia respond to white matter injury with different populations that prevent macrophage dispersion into spared tissue.
View article: Endoplasmic reticulum–mitochondria interplay in chronic pain: The calcium connection
Endoplasmic reticulum–mitochondria interplay in chronic pain: The calcium connection Open
Chronic pain is a debilitating condition that affects roughly a third to a half of the world’s population. Despite its substantial effect on society, treatment for chronic pain is modest, at best, notwithstanding its side effects. Hence, n…
View article: Microbes, microglia, and pain
Microbes, microglia, and pain Open
Globally, it is estimated that one in five people suffer from chronic pain, with prevalence increasing with age. The pathophysiology of chronic pain encompasses complex sensory, immune, and inflammatory interactions within both the central…
View article: Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE)
Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE) Open
Background Multiple sclerosis is an autoimmune disease with a distinct female bias, as well as a high prevalence of neuropathic pain in both sexes. The dorsal root ganglia (DRG) contain the primary sensory neurons that give rise to pain, a…
View article: Sensory Neurons of the Dorsal Root Ganglia Become Hyperexcitable in a T-Cell-Mediated MOG-EAE Model of Multiple Sclerosis
Sensory Neurons of the Dorsal Root Ganglia Become Hyperexcitable in a T-Cell-Mediated MOG-EAE Model of Multiple Sclerosis Open
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. Patients with MS typically present with visual, motor, and sensory deficits. However, an additional complication of MS in large subset of patien…
View article: MOESM5 of Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE)
MOESM5 of Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE) Open
Additional file 5: Table S5. Spreadsheet of RNASeq differential expression analysis between EAE conditions of females and males.
View article: MOESM2 of Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE)
MOESM2 of Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE) Open
Additional file 2: Table S2. Spreadsheet of RNASeq differential expression analysis between EAE and CFA condition in males.