Bradley D. Smith
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View article: Novel dimeric dual-modality FAP-targeted agents with favorable tumor retention for image-guided surgery: a preclinical study
Novel dimeric dual-modality FAP-targeted agents with favorable tumor retention for image-guided surgery: a preclinical study Open
Purpose Complete and minimally invasive cancer surgery remains challenging. Targeting the fibroblast activation protein (FAP) offers valuable opportunities for surgical planning, intraoperative guidance and improved resection outcomes. Her…
View article: Rotaxane Formation Increases Squaraine Fluorescence Brightness beyond 900 nm by 25-fold.
Rotaxane Formation Increases Squaraine Fluorescence Brightness beyond 900 nm by 25-fold. Open
A squaraine dye with two flanking benzo[cd]indoles absorbs strongly at 881 nm, but the fluorescence quantum yield is very low due to dye flexibility. Rigidification of the squaraine structure by encapsulation within a rotaxane produ…
View article: A Scoping Review of 50 Years of School-Based Mindfulness Interventions for Children and Adolescents
A Scoping Review of 50 Years of School-Based Mindfulness Interventions for Children and Adolescents Open
View article: Fluorescent molecular probe for <i>in vivo</i> and <i>in vitro</i> targeting and imaging of an intracellular bacterial infection
Fluorescent molecular probe for <i>in vivo</i> and <i>in vitro</i> targeting and imaging of an intracellular bacterial infection Open
This work presents a strategy to target bacteria-infected living cells selectively. A charged zinc complex conjugated to a near-infrared reporter permeates cell membranes and binds bacterial selectively in vitro and in vivo .
View article: Miniature wireless LED-device for photodynamic-induced cell pyroptosis
Miniature wireless LED-device for photodynamic-induced cell pyroptosis Open
The inability of visible light to penetrate far through biological tissue limits its use for phototherapy and photodiagnosis of deep-tissue sites of disease. This is unfortunate because many visible dyes are excellent photosensitizers and …
View article: Fluorescence Imaging Using Deep-Red Indocyanine Blue, a Complementary Partner for Near-Infrared Indocyanine Green
Fluorescence Imaging Using Deep-Red Indocyanine Blue, a Complementary Partner for Near-Infrared Indocyanine Green Open
Indocyanine Blue (ICB) is the deep-red pentamethine analogue of the widely used clinical near-infrared heptamethine cyanine dye Indocyanine Green (ICG). The two fluorophores have the same number of functional groups and molecular charge an…
View article: Fluorescence imaging using deep-red Indocyanine Blue (ICB) a complementary partner for near infrared Indocyanine Green (ICG)
Fluorescence imaging using deep-red Indocyanine Blue (ICB) a complementary partner for near infrared Indocyanine Green (ICG) Open
Indocyanine Blue (ICB) is the deep-red, pentamethine analogue of the widely used clinical near-infrared heptamethine cyanine dye, Indocyanine Green (ICG). The two fluorophores have the same number of functional groups and molecular charge …
View article: Cy5 Dye Cassettes Exhibit Through-Bond Energy Transfer and Enable Ratiometric Fluorescence Sensing
Cy5 Dye Cassettes Exhibit Through-Bond Energy Transfer and Enable Ratiometric Fluorescence Sensing Open
The chemosensor literature contains many reports of fluorescence sensing using polyaromatic hydrocarbon fluorophores such as pyrene, tetraphenylethylene, or polyaryl(ethynylene), where the fluorophore is excited with ultraviolet light (2+<…
View article: Ratiometric near-infrared fluorescent probe for nitroreductase activity enables 3D imaging of hypoxic cells within intact tumor spheroids
Ratiometric near-infrared fluorescent probe for nitroreductase activity enables 3D imaging of hypoxic cells within intact tumor spheroids Open
A ratiometric, near-infrared fluorescent molecular probe reports nitroreductase activity and enables three-dimensional optical sectioning of intact tumor spheroids with visualization of individual hypoxic cells.
View article: Steric protection of near-infrared fluorescent dyes for enhanced bioimaging
Steric protection of near-infrared fluorescent dyes for enhanced bioimaging Open
Steric protection of a long-wavelength dye, by covalent steric appendage or non-covalent encapsulation, produces enhanced photostability, increased fluorescence brightness, decreased self-aggregation, and superior pharmacokinetic profile.
View article: Fluorescent ratiometric supramolecular tandem assays for phosphatase and phytase enzymes
Fluorescent ratiometric supramolecular tandem assays for phosphatase and phytase enzymes Open
Two continuous ratiometric fluorescent assays for phosphate hydrolase enzymes are created based on selective binding and quenching of a responsive visible dye in the presence of a non-responsive deep-red reference dye.
View article: Fluorescent cyclopropyl ester probes are efficiently cleaved by endogenous carboxylesterase in mouse blood: implications for preclinical fluorescence imaging
Fluorescent cyclopropyl ester probes are efficiently cleaved by endogenous carboxylesterase in mouse blood: implications for preclinical fluorescence imaging Open
Prior studies have shown that fluorescent molecular probes based on cyclopropyl esters are good substrates for butyrylcholine esterase (BChE), which is a biomarker of several human diseases. We tested two fluorescent cyclopropyl ester deri…
View article: A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes
A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes Open
Strong‐binding host–guest pairings in aqueous media have potential as “supramolecular glues” in biomedical techniques, complementing the widely‐used (strept)avidin‐biotin combination. We have previously found that squaraine dyes are bound …
View article: A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes
A High‐Affinity “Synthavidin” Receptor for Squaraine Dyes Open
Strong‐binding host–guest pairings in aqueous media have potential as “supramolecular glues” in biomedical techniques, complementing the widely‐used (strept)avidin‐biotin combination. We have previously found that squaraine dyes are bound …
View article: Lipophilic Anchors that Embed Bioconjugates in Bilayer Membranes: A Review
Lipophilic Anchors that Embed Bioconjugates in Bilayer Membranes: A Review Open
A wide range of biomaterials and engineered cell surfaces are composed of bioconjugates embedded in liposome membranes, surface-immobilized bilayers, or the plasma membranes of living cells. This review article summarizes the various ways …
View article: Supramolecular Complexation of Azobenzene Dyes by Cucurbit[7]uril
Supramolecular Complexation of Azobenzene Dyes by Cucurbit[7]uril Open
This report describes cucurbit[7]uril (CB7) complexation of azobenzene dyes that have a 4-(N,N'-dimethylamino) or 4-amino substituent. Absorption and NMR data show that CB7 encapsulates the protonated form of the azobenzene a…
View article: Doubly Strapped Zwitterionic NIR‐I and NIR‐II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging
Doubly Strapped Zwitterionic NIR‐I and NIR‐II Heptamethine Cyanine Dyes for Bioconjugation and Fluorescence Imaging Open
Heptamethine cyanine dyes enable deep tissue fluorescence imaging in the near infrared (NIR) window. Small molecule conjugates of the benchmark dye ZW800‐1 have been tested in humans. However, long‐term imaging protocols using ZW800‐1 conj…
View article: Palladium responsive liposomes for triggered release of aqueous contents
Palladium responsive liposomes for triggered release of aqueous contents Open
View article: Palladium responsive liposomes for triggered release of aqueous contents
Palladium responsive liposomes for triggered release of aqueous contents Open
Palladium (Pd) is a promising metal catalyst for novel bioorthogonal chemistry and prodrug activation This report describes the first example of palladium responsive liposomes. The key molecule is a new caged phospholipid called Alloc-PE t…
View article: Probes for anionic cell surface detection
Probes for anionic cell surface detection Open
Embodiments of the present invention are generally directed to compositions comprising a class of molecular probes for detecting the presence of anionic cell surfaces. Embodiments include compositions that are enriched for these compositio…
View article: Palladium Responsive Liposomes for Triggered Release of Aqueous Contents
Palladium Responsive Liposomes for Triggered Release of Aqueous Contents Open
View article: The Effect of Branched Alkyl Chain Length on the Properties of Supramolecular Organogels from Mono-N-Alkylated Primary Oxalamides
The Effect of Branched Alkyl Chain Length on the Properties of Supramolecular Organogels from Mono-N-Alkylated Primary Oxalamides Open
Mono-N-alkylated primary oxalamide derivatives with different sized branched alkyl tail-groups were excellent low molecular weight gelators for a variety of different organic solvents with different polarities and hydrogen-bonding abilitie…
View article: Single-molecule characterization of a bright and photostable deep-red fluorescent squaraine-figure-eight (SF8) dye
Single-molecule characterization of a bright and photostable deep-red fluorescent squaraine-figure-eight (SF8) dye Open
View article: Spontaneous Transfer of Indocyanine Green from Liposomes to Albumin Is Inhibited by the Antioxidant α-Tocopherol
Spontaneous Transfer of Indocyanine Green from Liposomes to Albumin Is Inhibited by the Antioxidant α-Tocopherol Open
Indocyanine Green (ICG) is a clinically approved organic dye with near-infrared absorption and fluorescence. Over the years, many efforts to improve the photophysical and pharmacokinetic properties of ICG have investigated numerous nanopar…
View article: Cucurbit[7]uril Complexation of Near-Infrared Fluorescent Azobenzene-Cyanine Conjugates
Cucurbit[7]uril Complexation of Near-Infrared Fluorescent Azobenzene-Cyanine Conjugates Open
Two new azobenzene heptamethine cyanine conjugates exist as dispersed monomeric molecules in methanol solution and exhibit near-infrared (NIR) cyanine absorption and fluorescence. Both conjugates form non-emissive cyanine H-aggregates in w…
View article: Sterically Shielded Hydrophilic Analogs of Indocyanine Green
Sterically Shielded Hydrophilic Analogs of Indocyanine Green Open
A modular synthetic process enables two or four shielding arms to be appended strategically over the fluorochromes of near-infrared cyanine heptamethine dyes to create hydrophilic analogs of clinically approved indocyanine green. A key syn…
View article: Front Cover: Structure‐Activity Studies of Nitroreductase‐Responsive Near‐Infrared Heptamethine Cyanine Fluorescent Probes (Eur. J. Org. Chem. 23/2022)
Front Cover: Structure‐Activity Studies of Nitroreductase‐Responsive Near‐Infrared Heptamethine Cyanine Fluorescent Probes (Eur. J. Org. Chem. 23/2022) Open
The Front Cover illustrates the action of a cyanine-based fluorescent probe inside a hypoxic A549 cell. Nitroreductase enzyme, a well-known biomarker of hypoxia, transforms a carboxylic ester group on the central heptamethine chain through…
View article: CCDC 2152033: Experimental Crystal Structure Determination
CCDC 2152033: Experimental Crystal Structure Determination Open
View article: CCDC 2152030: Experimental Crystal Structure Determination
CCDC 2152030: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2152032: Experimental Crystal Structure Determination
CCDC 2152032: Experimental Crystal Structure Determination Open