Brady Hunt
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View article: Dosimetric evaluations using cycle-consistent generative adversarial network synthetic CT for MR-guided adaptive radiation therapy
Dosimetric evaluations using cycle-consistent generative adversarial network synthetic CT for MR-guided adaptive radiation therapy Open
Background Magnetic resonance (MR) guided radiation therapy combines high-resolution image capabilities of MRI with the precise targeting of radiation therapy. However, MRI does not provide the essential electron density information for ac…
View article: Cycle-consistent Generative Adversarial Network Synthetic CT for MR-only Adaptive Radiation Therapy on MR-Linac
Cycle-consistent Generative Adversarial Network Synthetic CT for MR-only Adaptive Radiation Therapy on MR-Linac Open
Purpose: This study assesses the effectiveness of Deep Learning (DL) for creating synthetic CT (sCT) images in MR-guided adaptive radiation therapy (MRgART). Methods: A Cycle-GAN model was trained with MRI and CT scan slices from MR-LINAC …
View article: DeltaAI: Semi-Autonomous Tissue Grossing Measurements and Recommendations using Neural Radiance Fields for Rapid, Complete Intraoperative Histological Assessment of Tumor Margins
DeltaAI: Semi-Autonomous Tissue Grossing Measurements and Recommendations using Neural Radiance Fields for Rapid, Complete Intraoperative Histological Assessment of Tumor Margins Open
Mohs Micrographic Surgery (MMS) aims to excise cutaneous cancer with real-time margin analysis. However, manual tissue grossing and analysis can be inefficient, so we propose DeltaAI, a novel workflow that utilizes Neural Radiance Fields (…
View article: Initial Observation of Contrast Profiles for 2-Dimensional and 3-Dimensional Magnetic Resonance Imaging Sequences in Magnetic Resonance–Guided Radiation Therapy for Locally Advanced Pancreatic Cancer
Initial Observation of Contrast Profiles for 2-Dimensional and 3-Dimensional Magnetic Resonance Imaging Sequences in Magnetic Resonance–Guided Radiation Therapy for Locally Advanced Pancreatic Cancer Open
There are significant variations in image intensity between the immediate pretreatment 2D cine compared with the initial planning 3D MRI. Understanding variations of image intensity between the different MRI sequences used in MRgRT is valu…
View article: Initial Observation of Contrast Profiles for 2D and 3D MRI Sequences in MR-Guided Radiation Therapy for Locally Advanced Pancreatic Cancer
Initial Observation of Contrast Profiles for 2D and 3D MRI Sequences in MR-Guided Radiation Therapy for Locally Advanced Pancreatic Cancer Open
Purpose In our experience treating locally advanced pancreatic cancer (PC) with magnetic resonance-guided radiation therapy (MRgRT), the true-fast imaging with steady-state free precession (TRUFI) sequences used to generate real-time 2D MR…
View article: Data from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial
Data from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial Open
Cervical cancer is a leading cause of death in underserved areas of Brazil. This prospective randomized trial involved 200 women in southern/central Brazil with abnormal Papanicolaou tests. Participants were randomized by geographic cluste…
View article: Data from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial
Data from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial Open
Cervical cancer is a leading cause of death in underserved areas of Brazil. This prospective randomized trial involved 200 women in southern/central Brazil with abnormal Papanicolaou tests. Participants were randomized by geographic cluste…
View article: Supplemental Methods from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial
Supplemental Methods from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial Open
This file contains more detailed information regarding data collection and management, data analysis, and training and usability of the high-resolution microendoscope (HRME).
View article: Table S1 from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial
Table S1 from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial Open
Comparison of human development index (HDI) and distance to central facility for the 79 geographic clusters.
View article: Supplemental Methods from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial
Supplemental Methods from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial Open
This file contains more detailed information regarding data collection and management, data analysis, and training and usability of the high-resolution microendoscope (HRME).
View article: Table S1 from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial
Table S1 from Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial Open
Comparison of human development index (HDI) and distance to central facility for the 79 geographic clusters.
View article: Fluorescence molecular optomic signatures improve identification of tumors in head and neck specimens
Fluorescence molecular optomic signatures improve identification of tumors in head and neck specimens Open
Background Fluorescence molecular imaging using ABY-029, an epidermal growth factor receptor (EGFR)-targeted, synthetic Affibody peptide labeled with a near-infrared fluorophore, is under investigation for surgical guidance during head and…
View article: Federated Learning for Multicenter Collaborations of Small Biomedical Research Institutions: A Framework for Navigating Challenges and Realizing Opportunities
Federated Learning for Multicenter Collaborations of Small Biomedical Research Institutions: A Framework for Navigating Challenges and Realizing Opportunities Open
The promises of Machine Learning (ML)-aided medicine have yet to be realized, in large part because robust optimization and generalizability of ML models requires large training datasets, which are logistically challenging to obtain. The m…
View article: Fluorescence molecular optomic signatures improve identification of tumors in head and neck specimens
Fluorescence molecular optomic signatures improve identification of tumors in head and neck specimens Open
In this study, a radiomics approach was extended to optical fluorescence molecular imaging data for tissue classification, termed 'optomics'. Fluorescence molecular imaging is emerging for precise surgical guidance during head and neck squ…
View article: Lighting gel filters as low-cost alternatives for fluorescence imaging and optical system design
Lighting gel filters as low-cost alternatives for fluorescence imaging and optical system design Open
Lighting gel filters are widely used in commercial industries, but their adoption in scientific applications is limited, despite their low cost and form factor advantages. Here, we compare the optical performance of lighting gel filters to…
View article: Developing diagnostic assessment of breast lumpectomy tissues using radiomic and optical signatures
Developing diagnostic assessment of breast lumpectomy tissues using radiomic and optical signatures Open
High positive margin rates in oncologic breast-conserving surgery are a pressing clinical problem. Volumetric X-ray scanning is emerging as a powerful ex vivo specimen imaging technique for analyzing resection margins, but X-rays lack cont…
View article: Ultracompact fluorescence smartphone attachment using built-in optics for protoporphyrin-IX quantification in skin
Ultracompact fluorescence smartphone attachment using built-in optics for protoporphyrin-IX quantification in skin Open
Smartphone-based fluorescence imaging systems have the potential to provide convenient quantitative image guidance at the point of care. However, common approaches have required the addition of complex optical attachments, which reduce tra…
View article: CT radiomic features of photodynamic priming in clinical pancreatic adenocarcinoma treatment
CT radiomic features of photodynamic priming in clinical pancreatic adenocarcinoma treatment Open
Photodynamic therapy (PDT) offers localized focal ablation in unresectable pancreatic tumors while tissues surrounding the treatment volume experience a lower light dose, termed photodynamic priming (PDP). While PDP does not cause tissue d…
View article: Deep Learning in Biomedical Optics
Deep Learning in Biomedical Optics Open
This article reviews deep learning applications in biomedical optics with a particular emphasis on image formation. The review is organized by imaging domains within biomedical optics and includes microscopy, fluorescence lifetime imaging,…
View article: Smartphone-based imaging systems for medical applications: a critical review
Smartphone-based imaging systems for medical applications: a critical review Open
A holistic assessment of SBI systems must include interpretation of their value for intended clinical settings and how their implementations enable better workflow. A set of six guidelines are proposed to evaluate appropriateness of smartp…
View article: Cervical lesion assessment using real‐time microendoscopy image analysis in Brazil: The <scp>CLARA</scp> study
Cervical lesion assessment using real‐time microendoscopy image analysis in Brazil: The <span>CLARA</span> study Open
We conducted a prospective evaluation of the diagnostic performance of high‐resolution microendoscopy (HRME) to detect cervical intraepithelial neoplasia (CIN) in women with abnormal screening tests. Study participants underwent colposcopy…
View article: High frame rate video mosaicking microendoscope to image large regions of intact tissue with subcellular resolution
High frame rate video mosaicking microendoscope to image large regions of intact tissue with subcellular resolution Open
High-resolution microendoscopy (HRME) is a low-cost strategy to acquire images of intact tissue with subcellular resolution at frame rates ranging from 11 to 18 fps. Current HRME imaging strategies are limited by the small microendoscope f…
View article: Compressed archive of 3D models used for fabricating multiple versions of optical attachments for smartphone-based fluorescence quantification
Compressed archive of 3D models used for fabricating multiple versions of optical attachments for smartphone-based fluorescence quantification Open
The compressed archive (.zip) contains individual .stl files for four different attachment versions defined by their sampling field of view and filter set utilized.
View article: Part specifications and material cost of five different versions of a smartphone-based fluorescence imaging system for iPhone 12
Part specifications and material cost of five different versions of a smartphone-based fluorescence imaging system for iPhone 12 Open
The spreadsheet contains a detailed list of part specifications for each attachment evaluated.
View article: Development of Low-Cost Point-of-Care Technologies for Cervical Cancer Prevention Based on a Single-Board Computer
Development of Low-Cost Point-of-Care Technologies for Cervical Cancer Prevention Based on a Single-Board Computer Open
Cervical cancer disproportionally affects women in low- and middle-income countries, in part due to the difficulty of implementing existing cervical cancer screening and diagnostic technologies in low-resource settings. Single-board comput…
View article: Advances in technologies for cervical cancer detection in low-resource settings
Advances in technologies for cervical cancer detection in low-resource settings Open
Introduction: Cervical cancer mortality rates remain high in low- and middle-income countries (LMICs) and other medically underserved areas due to challenges with implementation and sustainability of routine screening, accurate diagnosis, …
View article: Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report
Is Proflavine Exposure Associated with Disease Progression in Women with Cervical Dysplasia? A Brief Report Open
Proflavine is an acridine dye used with high‐resolution microendoscopy for in vivo diagnostic evaluation of cervical epithelial cells. However, there are concerns that even short‐term exposure of cervical tissue to dilute proflavine may in…
View article: Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial
Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped with <i>In Vivo</i> Microscopy: A Cluster-Randomized Community Trial Open
Cervical cancer is a leading cause of death in underserved areas of Brazil. This prospective randomized trial involved 200 women in southern/central Brazil with abnormal Papanicolaou tests. Participants were randomized by geographic cluste…