Nathan Brady
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View article: The Cancer/Testis Antigen FATE1 Antagonizes Fission and Preserves Mitochondrial Network Integrity under Cytotoxic Stress
The Cancer/Testis Antigen FATE1 Antagonizes Fission and Preserves Mitochondrial Network Integrity under Cytotoxic Stress Open
FATE1 (Fetal and Adult Testis Expressed 1), also known as BJ-HCC-2, is a cancer-testis antigen with highly restricted expression in normal tissues but aberrant activation in diverse tumor types, where it localizes to both the outer mitocho…
View article: Optical orbital angular momentum analogy to the Stern–Gerlach experiment
Optical orbital angular momentum analogy to the Stern–Gerlach experiment Open
Symmetry breaking has been shown to reveal interesting phenomena in physical systems. A notable example is the fundamental work of Otto Stern and Walther Gerlach [ Stern and Zerlach, Z. Physik 9 , 349 ( 1922 ) 10.1007/BF01326983 ] nearly 1…
View article: Prediction of Prostate Cancer Biochemical and Clinical Recurrence Is Improved by IHC-Assisted Grading Using Appl1, Sortilin and Syndecan-1
Prediction of Prostate Cancer Biochemical and Clinical Recurrence Is Improved by IHC-Assisted Grading Using Appl1, Sortilin and Syndecan-1 Open
Gleason scoring is used within a five-tier risk stratification system to guide therapeutic decisions for patients with prostate cancer. This study aimed to compare the predictive performance of routine H&E or biomarker-assisted ISUP (Inter…
View article: XIAP-mediated targeting of endolysosomes to stressed mitochondria occurs in a switch-like, global manner and results in autophagy-independent, sub-organelle level mitochondrial degradation
XIAP-mediated targeting of endolysosomes to stressed mitochondria occurs in a switch-like, global manner and results in autophagy-independent, sub-organelle level mitochondrial degradation Open
Damaged mitochondria can be subject to lysosomal degradation via mitophagy. However, whole-organelle degradation exhibits relatively slow kinetics and thus its impact may be limited in response to acute, fast-acting cellular stress. We pre…
View article: Metabolic programs define dysfunctional immune responses in severe COVID-19 patients
Metabolic programs define dysfunctional immune responses in severe COVID-19 patients Open
It is unclear why some SARS-CoV-2 patients readily resolve infection while others develop severe disease. By interrogating metabolic programs of immune cells in severe and recovered coronavirus disease 2019 (COVID-19) patients compared wit…
View article: Mitochondrial induced T cell apoptosis and aberrant myeloid metabolic programs define distinct immune cell subsets during acute and recovered SARS-CoV-2 infection
Mitochondrial induced T cell apoptosis and aberrant myeloid metabolic programs define distinct immune cell subsets during acute and recovered SARS-CoV-2 infection Open
By interrogating metabolic programs in the peripheral blood mononuclear cells (PBMC) of acutely infected COVID-19 patients, we identified novel and distinct immune cell subsets Our studies identified a non-clonal population of T cells expr…
View article: Study of Microbial Extracellular Vesicles: Separation by Density Gradients, Protection Assays and Labelling for Live Tracking
Study of Microbial Extracellular Vesicles: Separation by Density Gradients, Protection Assays and Labelling for Live Tracking Open
Extracellular vesicles (EVs) are produced by all domains of life including Bacteria, Archaea and Eukarya. EVs are critical for cellular physiology and contain varied cargo: virulence factors, cell wall remodeling enzymes, extracellular mat…
View article: Design principles of ROS dynamic networks relevant to precision therapies for age-related diseases
Design principles of ROS dynamic networks relevant to precision therapies for age-related diseases Open
The eminently complex regulatory network protecting the cell against oxidative stress, surfaces in several disease maps, including that of Parkinson’s disease (PD). How this molecular networking achieves its various functionalities and how…
View article: <i>Listeria monocytogenes</i>virulence factors are secreted in biologically active Extracellular Vesicles
<i>Listeria monocytogenes</i>virulence factors are secreted in biologically active Extracellular Vesicles Open
Outer membrane vesicles produced by Gram-negative bacteria have been studied for half a century but the possibility that Gram-positive bacteria secreted extracellular vesicles (EVs) was not pursued due to the assumption that the thick pept…
View article: Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins
Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins Open
The mitophagy receptor Nix interacts with LC3/GABARAP proteins, targeting mitochondria into autophagosomes for degradation. Here we present evidence for phosphorylation-driven regulation of the Nix:LC3B interaction. Isothermal titration ca…
View article: Systemic deregulation of autophagy upon loss of ALS- and FTD-linked C9orf72
Systemic deregulation of autophagy upon loss of ALS- and FTD-linked C9orf72 Open
A genetic mutation in the C9orf72 gene causes the most common forms of neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The C9orf72 protein, predicted to be a DENN-family protein, is reduced…
View article: Agent-Based Modeling of Mitochondria Links Sub-Cellular Dynamics to Cellular Homeostasis and Heterogeneity
Agent-Based Modeling of Mitochondria Links Sub-Cellular Dynamics to Cellular Homeostasis and Heterogeneity Open
Mitochondria are semi-autonomous organelles that supply energy for cellular biochemistry through oxidative phosphorylation. Within a cell, hundreds of mobile mitochondria undergo fusion and fission events to form a dynamic network. These m…
View article: Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling
Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling Open
The most common cause of the neurodegenerative diseases amyotrophic lateral sclerosis and frontotemporal dementia is a hexanucleotide repeat expansion in C9orf72. Here we report a study of the C9orf72 protein by examining the consequences …
View article: Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62
Dengue Virus Inhibition of Autophagic Flux and Dependency of Viral Replication on Proteasomal Degradation of the Autophagy Receptor p62 Open
Autophagic flux involves formation of autophagosomes and their degradation by lysosomes. Autophagy can either promote or restrict viral replication. In the case of Dengue virus (DENV), several studies report that autophagy supports the vir…
View article: Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells
Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells Open
Oncogenic KRas reprograms pancreatic ductal adenocarcinoma (PDAC) cells to states which are highly resistant to apoptosis. Thus, a major preclinical goal is to identify effective strategies for killing PDAC cells. Artesunate (ART) is an an…