Brahim Arkoun
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View article: ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis
ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis Open
Sustained ANKRD26 expression associated with germline ANKRD26 mutations causes thrombocytopenia 2 (THC2), an inherited platelet disorder associated with a predisposition to leukemia. Some patients also present with erythrocytosis and/or le…
View article: Sorting and Manipulation of Human PGC-LC Using PDPN and Hanging Drop Cultures
Sorting and Manipulation of Human PGC-LC Using PDPN and Hanging Drop Cultures Open
The generation of oocytes from induced pluripotent stem cells (iPSCs) was proven efficient with mouse cells. However, no human iPSCs have yet been reported to generate cells able to complete oogenesis. Additionally, efficient sorting of hu…
View article: ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis
ANKRD26 is a new regulator of type I cytokine receptor signaling in normal and pathological hematopoiesis Open
Sustained ANKRD26 expression associated with germline ANKRD26 mutations causes Thrombocytopenia 2 (THC2), an inherited platelet disorder associated with leukemia predisposition. Some of those patients present also erythrocytosis and/or leu…
View article: Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model
Stepwise GATA1 and SMC3 mutations alter megakaryocyte differentiation in a Down syndrome leukemia model Open
Acute megakaryoblastic leukemia of Down syndrome (DS-AMKL) is a model of clonal evolution from a preleukemic transient myeloproliferative disorder requiring both a trisomy 21 (T21) and a GATA1s mutation to a leukemia driven by additional d…
View article: Dual role of EZH2 in megakaryocyte differentiation
Dual role of EZH2 in megakaryocyte differentiation Open
EZH2, the enzymatic component of PRC2, has been identified as a key factor in hematopoiesis. EZH2 loss-of-function mutations have been found in myeloproliferative neoplasms, particularly in myelofibrosis, but the precise function of EZH2 i…
View article: Role of Rho-GTPases in megakaryopoiesis
Role of Rho-GTPases in megakaryopoiesis Open
Megakaryocytes (MKs) are the bone marrow (BM) cells that generate blood platelets by a process that requires: i) polyploidization responsible for the increased MK size and ii) cytoplasmic organization leading to extension of long pseudopod…
View article: Induced pluripotent stem cells and hematological malignancies: A powerful tool for disease modeling and drug development
Induced pluripotent stem cells and hematological malignancies: A powerful tool for disease modeling and drug development Open
The derivation of human pluripotent stem cell (iPSC) lines by in vitro reprogramming of somatic cells revolutionized research: iPSCs have been used for disease modeling, drug screening and regenerative medicine for many disorders, especial…
View article: Vitamin E but Not GSH Decreases Reactive Oxygen Species Accumulation and Enhances Sperm Production during In Vitro Maturation of Frozen-Thawed Prepubertal Mouse Testicular Tissue
Vitamin E but Not GSH Decreases Reactive Oxygen Species Accumulation and Enhances Sperm Production during In Vitro Maturation of Frozen-Thawed Prepubertal Mouse Testicular Tissue Open
Freezing–thawing procedures and in vitro culture conditions are considered as a source of stress associated with increased reactive oxygen species (ROS) generation, leading to a damaged cell aerobic metabolism and consequently to oxidative…
View article: Human foetal ovary shares meiotic preventing factors with the developing testis
Human foetal ovary shares meiotic preventing factors with the developing testis Open
This research was supported by the Université Paris Diderot-Paris 7 and Université Paris-Sud, CEA, INSERM, and Agence de la Biomédecine. The authors declare no conflict of interest.
View article: Time course of spermatogenesis in mice and i<i>n vitro</i> culture procedure.
Time course of spermatogenesis in mice and i<i>n vitro</i> culture procedure. Open
(A) Schematic overview of the timeline of spermatogenesis during post-natal mouse development (A1) and procedure for the in vitro culture of prepubertal mice testes used in the present study (A2). The culture media tested for the culture o…
View article: Assessment of the optimal vitrification protocol for pre-pubertal mice testes leading to successful in vitro production of flagellated spermatozoa
Assessment of the optimal vitrification protocol for pre-pubertal mice testes leading to successful in vitro production of flagellated spermatozoa Open
Testicular tissue cryopreservation offers the hope of preserved future fertility to pre-pubertal boys with cancer before exposition to gonadotoxic treatments. The objective of this study was to compare controlled slow freezing (CSF) with f…
View article: Retinol Improves In Vitro Differentiation of Pre-Pubertal Mouse Spermatogonial Stem Cells into Sperm during the First Wave of Spermatogenesis
Retinol Improves In Vitro Differentiation of Pre-Pubertal Mouse Spermatogonial Stem Cells into Sperm during the First Wave of Spermatogenesis Open
Testicular tissue freezing has been proposed for fertility preservation in pre-pubertal boys. Thawed frozen testicular tissue must undergo a maturation process to restore sperm production. The purpose of the current study was to evaluate t…