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View article: External validation of a therapeutic window for risperidone in children with autism spectrum disorder
External validation of a therapeutic window for risperidone in children with autism spectrum disorder Open
Although risperidone is an effective pharmacological intervention for managing disruptive behaviour in children with autism spectrum disorder, it may induce metabolic side effects. This study aimed to externally validate the population pha…
View article: ADHD medication dispensing trends in Dutch youth before and after the implementation of the Youth Act (2010–2022)
ADHD medication dispensing trends in Dutch youth before and after the implementation of the Youth Act (2010–2022) Open
Objective: The Youth Act, implemented by the Dutch government in 2015, aimed to provide more efficient, coherent, and cost-effective care tailored to the specific needs of children, while also reducing medicalization. Between 2003 and 2013…
View article: Alterations of appetite‐regulating hormones in risperidone treated children and adolescents—a post hoc analysis of the SPACe study
Alterations of appetite‐regulating hormones in risperidone treated children and adolescents—a post hoc analysis of the SPACe study Open
Weight gain and metabolic disruptions are common in children and adolescents treated with antipsychotics, but the underlying mechanisms are unclear, complicating prevention and treatment. This study examines the impact of risperidone on ap…
View article: Game-Based eHealth Interventions for the Reduction of Fatigue in People With Chronic Diseases: Systematic Review and Meta-Analysis
Game-Based eHealth Interventions for the Reduction of Fatigue in People With Chronic Diseases: Systematic Review and Meta-Analysis Open
Background Fatigue is a common and debilitating side effect of chronic diseases, significantly impacting patients’ quality of life. While physical exercise and psychological treatments have been shown to reduce fatigue, patients often stru…
View article: Autism Spectrum Disorder Symptom Profiles in Fragile X Syndrome, Angelman Syndrome, Tuberous Sclerosis Complex and Neurofibromatosis Type 1
Autism Spectrum Disorder Symptom Profiles in Fragile X Syndrome, Angelman Syndrome, Tuberous Sclerosis Complex and Neurofibromatosis Type 1 Open
Studying Autism Spectrum Disorder (ASD) heterogeneity in biologically homogeneous samples may increase our knowledge of ASD etiology. Fragile X syndrome (FXS), Angelman syndrome (AS), Tuberous Sclerosis Complex (TSC), and Neurofibromatosis…
View article: Design Process of ROOM: A Mobile Intervention Supporting University Students’ Well-Being (Preprint)
Design Process of ROOM: A Mobile Intervention Supporting University Students’ Well-Being (Preprint) Open
BACKGROUND University students are experiencing a multitude of challenges and a rise in mental health issues impacting their academic performance and overall well-being. In response, Erasmus University Rotterdam started the Student Wellbe…
View article: ROOM to grow, a Mobile Wellbeing Intervention for University Students: Overview of the Design Process and Outcomes (Preprint)
ROOM to grow, a Mobile Wellbeing Intervention for University Students: Overview of the Design Process and Outcomes (Preprint) Open
View article: Brain, behavior, cognition, and physical health in first-onset adolescent anorexia nervosa: The BRAVE Study design and cohort profile
Brain, behavior, cognition, and physical health in first-onset adolescent anorexia nervosa: The BRAVE Study design and cohort profile Open
Background Anorexia nervosa is a severe psychiatric disorder with a heterogeneous course with one of the highest rates of morbidity and mortality of all psychiatric disorders. Little is known about factors that predict both course and trea…
View article: Correction to: Comparison of antipsychotic drug use in children and adolescents in the Netherlands before and during the COVID-19 pandemic
Correction to: Comparison of antipsychotic drug use in children and adolescents in the Netherlands before and during the COVID-19 pandemic Open
View article: The implications of the COVID-19 pandemic on eating disorder features and comorbid psychopathology among adolescents with anorexia nervosa and matched controls: a comparative cohort design study
The implications of the COVID-19 pandemic on eating disorder features and comorbid psychopathology among adolescents with anorexia nervosa and matched controls: a comparative cohort design study Open
Purpose To examine implications of the COVID-19 pandemic on eating disorder (ED) features and psychopathology in female adolescents with anorexia nervosa (AN). Method In total 79 females with first-onset AN (aged 12–22 years) were included…
View article: Correction to: Pharmacotherapy for ADHD in children and adolescents: A summary and overview of different European guidelines
Correction to: Pharmacotherapy for ADHD in children and adolescents: A summary and overview of different European guidelines Open
View article: Comparison of antipsychotic drug use in children and adolescents in the Netherlands before and during the COVID-19 pandemic
Comparison of antipsychotic drug use in children and adolescents in the Netherlands before and during the COVID-19 pandemic Open
This study aims to describe the patterns and trends in antipsychotic prescription among Dutch youth before and during the corona virus disease 2019 (COVID-19) pandemic (between 2017 and 2022). The study specifically aims to determine wheth…
View article: Cannabidiol (Epidyolex®) for severe behavioral manifestations in patients with tuberous sclerosis complex, mucopolysaccharidosis type III and fragile X syndrome: protocol for a series of randomized, placebo-controlled N-of-1 trials
Cannabidiol (Epidyolex®) for severe behavioral manifestations in patients with tuberous sclerosis complex, mucopolysaccharidosis type III and fragile X syndrome: protocol for a series of randomized, placebo-controlled N-of-1 trials Open
View article: Therapeutic Drug Monitoring to Optimize Risperidone Treatment in Children with Autism Spectrum Disorder
Therapeutic Drug Monitoring to Optimize Risperidone Treatment in Children with Autism Spectrum Disorder Open
Background: Risperidone is an atypical antipsychotic drug used to treat irritability and aggression in children and adolescents with autism spectrum disorder. In an earlier study, the sum trough concentration of risperidone and its metabol…
View article: Internalizing and externalizing behaviors in school-aged children are related to state anxiety during magnetic resonance imaging
Internalizing and externalizing behaviors in school-aged children are related to state anxiety during magnetic resonance imaging Open
Magnetic resonance imaging (MRI) procedures often evoke anxiety in children. Further, anxious children may be less likely to participate in MRI research, leading to a possible selection bias, and may be more likely to move during image acq…
View article: Towards precision dosing of aripiprazole in children and adolescents with autism spectrum disorder: Linking blood levels to weight gain and effectiveness
Towards precision dosing of aripiprazole in children and adolescents with autism spectrum disorder: Linking blood levels to weight gain and effectiveness Open
Aims Aripiprazole is one of the most commonly prescribed antipsychotic drugs to children and adolescents worldwide, but it is associated with serious side‐effects, including weight gain. This study assessed the population pharmacokinetics …
View article: Effect of chemotherapy (with and without radiotherapy) on the intelligence of children and adolescents treated for acute lymphoblastic leukemia; a meta‐analysis
Effect of chemotherapy (with and without radiotherapy) on the intelligence of children and adolescents treated for acute lymphoblastic leukemia; a meta‐analysis Open
Objective This meta‐analysis assesses cognitive functioning in children with acute lymphoblastic leukemia post‐treatment who were treated with either chemotherapy‐only (CT‐only) or in combination with radiation therapy (CTRT). Methods The …
View article: Clinical pharmacokinetics of antipsychotics in pediatric populations: a scoping review focusing on dosing regimen
Clinical pharmacokinetics of antipsychotics in pediatric populations: a scoping review focusing on dosing regimen Open
Achieving optimal clinical responses and minimizing side effects through precision dosing of antipsychotics in children and adolescents with psychiatric disorders remains a challenge. Identifying patient characteristics (covariates) that a…
View article: The effect of therapeutic drug monitoring of risperidone and aripiprazole on weight gain in children and adolescents: the SPACe 2: STAR (trial) protocol of an international multicentre randomised controlled trial
The effect of therapeutic drug monitoring of risperidone and aripiprazole on weight gain in children and adolescents: the SPACe 2: STAR (trial) protocol of an international multicentre randomised controlled trial Open
View article: Comparing Smartphone Virtual Reality Exposure Preparation to Care as Usual in Children Aged 6 to 14 Years Undergoing Magnetic Resonance Imaging: Protocol for a Multicenter, Observer-Blinded, Randomized Controlled Trial
Comparing Smartphone Virtual Reality Exposure Preparation to Care as Usual in Children Aged 6 to 14 Years Undergoing Magnetic Resonance Imaging: Protocol for a Multicenter, Observer-Blinded, Randomized Controlled Trial Open
Background A magnetic resonance imaging (MRI) procedure can cause preprocedural and periprocedural anxiety in children. Psychosocial interventions are used to prepare children for the procedure to alleviate anxiety, but these interventions…
View article: Virtual reality in pediatrics, effects on pain and anxiety: A systematic review and meta‐analysis update
Virtual reality in pediatrics, effects on pain and anxiety: A systematic review and meta‐analysis update Open
Introduction Medical procedures are often accompanied by pain and anxiety in pediatric patients. A relatively new technique to reduce pediatric pain and anxiety is virtual reality. Virtual reality is both applied as a distraction tool and …
View article: Smartphone Virtual Reality Exposure Tool as Psychological Preparation for Children Undergoing an MRI: Developmental considerations and study protocol. (Preprint)
Smartphone Virtual Reality Exposure Tool as Psychological Preparation for Children Undergoing an MRI: Developmental considerations and study protocol. (Preprint) Open
BACKGROUND An MRI-procedure can cause preprocedural and periprocedural anxiety in children. Psychosocial interventions are used to prepare children for the procedure to alleviate anxiety, but these interventions are time- and cost consumi…
View article: Autism Symptoms in Children and Young Adults With Fragile X Syndrome, Angelman Syndrome, Tuberous Sclerosis Complex, and Neurofibromatosis Type 1: A Cross-Syndrome Comparison
Autism Symptoms in Children and Young Adults With Fragile X Syndrome, Angelman Syndrome, Tuberous Sclerosis Complex, and Neurofibromatosis Type 1: A Cross-Syndrome Comparison Open
Objective The etiology of autism spectrum disorder (ASD) remains unclear, due to genetic heterogeneity and heterogeneity in symptoms across individuals. This study compares ASD symptomatology between monogenetic syndromes with a high ASD p…
View article: Comparison of antipsychotic drug use among Dutch Youth before and after implementation of the Youth Act (2010–2019)
Comparison of antipsychotic drug use among Dutch Youth before and after implementation of the Youth Act (2010–2019) Open
View article: Internalizing and externalizing behaviors in school-aged children are related to state anxiety during magnetic resonance imaging
Internalizing and externalizing behaviors in school-aged children are related to state anxiety during magnetic resonance imaging Open
Magnetic resonance imaging (MRI) procedures often evoke anxiety in children. Further, anxious children may be less likely to participate in MRI research, leading to a possible selection bias, and may be more likely to move during image acq…
View article: Methylphenidate Treatment Adherence and Persistence in Children in the Netherlands
Methylphenidate Treatment Adherence and Persistence in Children in the Netherlands Open
Objectives: Numerous studies have examined determinants contributing to methylphenidate adherence and persistence, but these were mainly conducted in adults. These determinants are likely to be different in children as they u…
View article: Risk factors and pattern of weight gain in youths using antipsychotic drugs
Risk factors and pattern of weight gain in youths using antipsychotic drugs Open
View article: Risperidone plasma concentrations are associated with side effects and effectiveness in children and adolescents with autism spectrum disorder
Risperidone plasma concentrations are associated with side effects and effectiveness in children and adolescents with autism spectrum disorder Open
Aim Risperidone is the most commonly prescribed antipsychotic drug to children and adolescents worldwide, but it is associated with serious side effects, including weight gain. This study assessed the relationship of risperidone and 9‐hydr…
View article: Maternal Sociodemographic Factors Are Associated with Methylphenidate Initiation in Children in the Netherlands: A Population-Based Study
Maternal Sociodemographic Factors Are Associated with Methylphenidate Initiation in Children in the Netherlands: A Population-Based Study Open
View article: Feasibility of Dried Blood Spots in Children with Behavioral Problems
Feasibility of Dried Blood Spots in Children with Behavioral Problems Open
Background: Minimally invasive sampling methods are important to facilitate therapeutic drug monitoring and pharmacokinetic research in children with behavioral problems. This study assessed the feasibility and pain of dried blood spot (DB…