Bram G. Janssen
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View article: Federated and reusable processing of Earth observation data
Federated and reusable processing of Earth observation data Open
View article: The association between ambient particulate matter exposure and the telomere–mitochondrial axis of aging in newborns
The association between ambient particulate matter exposure and the telomere–mitochondrial axis of aging in newborns Open
View article: In utero particulate matter exposure in association with newborn mitochondrial ND4L10550A>G heteroplasmy and its role in overweight during early childhood
In utero particulate matter exposure in association with newborn mitochondrial ND4L10550A>G heteroplasmy and its role in overweight during early childhood Open
View article: The telomere-mitochondrial axis of aging in newborns
The telomere-mitochondrial axis of aging in newborns Open
Aging starts at the beginning of life as evidenced by high variability in telomere length (TL) and mitochondrial DNA content (mtDNAc) at birth. Whether p53 and PGC-1α are connected to these age-related markers in early life is unclear. In …
View article: Dynamics of skin microvascular blood flow in 4–6-year-old children in association with pre- and postnatal black carbon and particulate air pollution exposure
Dynamics of skin microvascular blood flow in 4–6-year-old children in association with pre- and postnatal black carbon and particulate air pollution exposure Open
Our findings support that BC, particulate air pollution, and NO2 exposure, even at low concentrations, during prenatal life, can have long-lasting consequences for the microvasculature. This proposes a role of prenatal air pollu…
View article: Glomerular function in relation to fine airborne particulate matter in a representative population sample
Glomerular function in relation to fine airborne particulate matter in a representative population sample Open
View article: Glomerular Function in Relation to Fine Airborne Particulate Matter in a Representative Population Sample
Glomerular Function in Relation to Fine Airborne Particulate Matter in a Representative Population Sample Open
Whereas the adverse impact of fine particulate matter on coronary heart disease and respiratory disorders has been clarified, its influence on glomerular function is not well defined in population studies. Serum creatinine levels were quan…
View article: Child buccal telomere length and mitochondrial DNA content as biomolecular markers of ageing in association with air pollution
Child buccal telomere length and mitochondrial DNA content as biomolecular markers of ageing in association with air pollution Open
View article: Ambient air pollution exposure during the late gestational period is linked with lower placental iodine load in a Belgian birth cohort
Ambient air pollution exposure during the late gestational period is linked with lower placental iodine load in a Belgian birth cohort Open
View article: Dynamics of skin microvascular blood flow in 4-6 year old children in association with pre- and postnatal black carbon and particulate air pollution exposure
Dynamics of skin microvascular blood flow in 4-6 year old children in association with pre- and postnatal black carbon and particulate air pollution exposure Open
Background: A growing body of evidence shows that cardiovascular disease in adulthood, in particular that of the microcirculation, could find its roots during prenatal development. In this study we investigated the association between pre-…
View article: Association of Retinal Microvascular Characteristics With Short-term Memory Performance in Children Aged 4 to 5 Years
Association of Retinal Microvascular Characteristics With Short-term Memory Performance in Children Aged 4 to 5 Years Open
These findings suggest that children's microvascular phenotypes are associated with short-term memory and that changes in the retinal microvasculature may reflect neurological development during early childhood.
View article: Mitochondrial DNA methylation in placental tissue: a proof of concept study by means of prenatal environmental stressors
Mitochondrial DNA methylation in placental tissue: a proof of concept study by means of prenatal environmental stressors Open
While previous studies have demonstrated that prenatal exposure to environmental stressors is associated with mitochondrial DNA (mtDNA) methylation, more recent investigations are questioning the accuracy of the methylation assessment and …
View article: Children’s microvascular traits and ambient air pollution exposure during pregnancy and early childhood: prospective evidence to elucidate the developmental origin of particle-induced disease
Children’s microvascular traits and ambient air pollution exposure during pregnancy and early childhood: prospective evidence to elucidate the developmental origin of particle-induced disease Open
Background Particulate matter exposure during in utero life may entail adverse health outcomes later in life. The microvasculature undergoes extensive, organ-specific prenatal maturation. A growing body of evidence shows that cardiovascula…
View article: Association of Prenatal Exposure to Ambient Air Pollution With Circulating Histone Levels in Maternal Cord Blood
Association of Prenatal Exposure to Ambient Air Pollution With Circulating Histone Levels in Maternal Cord Blood Open
Associations of ambient air pollution with cord plasma histone H3 modifications during early life might indicate that circulating histones are a risk factor in the development of air pollution-associated disease later in life. Additional s…
View article: Association of Parental Socioeconomic Status and Newborn Telomere Length
Association of Parental Socioeconomic Status and Newborn Telomere Length Open
This study suggests that parental socioeconomic status is associated with newborn TL, especially in boys. The results indicate that familial social economic factors are associated with the potential cellular longevity of the next generatio…
View article: Pre-admission air pollution exposure prolongs the duration of ventilation in intensive care patients
Pre-admission air pollution exposure prolongs the duration of ventilation in intensive care patients Open
View article: Breastfeeding predicts blood mitochondrial DNA content in adolescents
Breastfeeding predicts blood mitochondrial DNA content in adolescents Open
Nutrition during early childhood is linked to metabolic programming. We hypothesized that breastfeeding has long-term consequences on the energy metabolism exemplified by mitochondrial DNA (mtDNA). As part of the third cycle of the Flemish…
View article: Variability of iodine concentrations in the human placenta
Variability of iodine concentrations in the human placenta Open
View article: Mitochondrial DNA methylation in placental tissue: a proof of concept study by means of prenatal environmental stressors
Mitochondrial DNA methylation in placental tissue: a proof of concept study by means of prenatal environmental stressors Open
While previous studies have demonstrated that prenatal exposure to environmental stressors is associated with mitochondrial DNA (mtDNA) methylation, more recent investigations are questioning the accuracy of the methylation assessment and …
View article: Placental mitochondrial DNA content is associated with childhood intelligence
Placental mitochondrial DNA content is associated with childhood intelligence Open
Background Developmental processes in the placenta and the fetal brain are shaped by the similar biological signals. Evidence accumulates that adaptive responses of the placenta may influence central nervous system development. We hypothes…
View article: Newborn histone modifications and gestational exposure to particulate matter air pollution: the ENVIRONAGE Cohort Study
Newborn histone modifications and gestational exposure to particulate matter air pollution: the ENVIRONAGE Cohort Study Open
OPS 48: Air pollution and epigenetics, Room 417, Floor 4, August 26, 2019, 4:30 PM - 5:30 PM Background: Exposure to particulate air pollution has been linked with risk of disease in later life. Changes in DNA histone modifications might h…
View article: Higher Neonatal Blood Pressure in Association with Air Pollution Exposure during the Last Weeks of Pregnancy: an ENVIRONAGE birth cohort study
Higher Neonatal Blood Pressure in Association with Air Pollution Exposure during the Last Weeks of Pregnancy: an ENVIRONAGE birth cohort study Open
TPS 742: Adverse birth outcomes 1, Exhibition Hall, Ground floor, August 27, 2019, 3:00 PM - 4:30 PM Background: Elevated blood pressure (BP) in early life may lead to cardiovascular morbidity and mortality in adulthood. Air pollution expo…
View article: Linking mitochondrial and telomere damage in foetal tissue: TP53 and PPARGC1α as a central hub?
Linking mitochondrial and telomere damage in foetal tissue: TP53 and PPARGC1α as a central hub? Open
PDS 71: Exposome, Johan Friso Foyer, Floor 1, August 27, 2019, 4:30 PM - 5:30 PM Background: Observations from experimental studies have put forth a "core axis of ageing" involving telomeres, mitochondria, TP53, and peroxisome proliferator…
View article: Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype?
Air pollution-induced placental alterations: an interplay of oxidative stress, epigenetics, and the aging phenotype? Open
View article: Histone H3 levels and modifications in association with gestational particulate matter exposure: the ENVIRONAGE cohort study
Histone H3 levels and modifications in association with gestational particulate matter exposure: the ENVIRONAGE cohort study Open
[Vrijens, Karen; Trippas, Ann-Julie; Janssen, Bram; Plusquin, Michelle; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Lefebvre, Wouter] Flemish Inst Technol Res VITO, Mol, Belgium. [Vanpoucke, Charlotte] Belgian Int…
View article: Neonatal blood pressure in association with prenatal air pollution exposure, traffic, and land use indicators: An ENVIRONAGE birth cohort study
Neonatal blood pressure in association with prenatal air pollution exposure, traffic, and land use indicators: An ENVIRONAGE birth cohort study Open
View article: The Cord Blood Insulin and Mitochondrial DNA Content Related Methylome
The Cord Blood Insulin and Mitochondrial DNA Content Related Methylome Open
Mitochondrial dysfunction seems to play a key role in the etiology of insulin resistance. At birth, a link has already been established between mitochondrial DNA (mtDNA) content and insulin levels in cord blood. In this study, we explore s…
View article: Cord blood leptin and insulin levels in association with mitochondrial DNA content
Cord blood leptin and insulin levels in association with mitochondrial DNA content Open
View article: Mitochondrial DNA content in blood and carbon load in airway macrophages. A panel study in elderly subjects
Mitochondrial DNA content in blood and carbon load in airway macrophages. A panel study in elderly subjects Open
View article: Placental promoter methylation of DNA repair genes and prenatal exposure to particulate air pollution: an ENVIR ON AGE cohort study
Placental promoter methylation of DNA repair genes and prenatal exposure to particulate air pollution: an ENVIR ON AGE cohort study Open
European Research Council and the Flemish Scientific Fund.