Explanipedia

Evaluation of renal sodium handling in heart failure with preserved ejection fraction: A pilot study Open

Adhish Agarwal, Srinivasan Beddhu, Robert E. Boucher, Veena Rao, Nirupama Ramkumar , et al. · 2024

The pathophysiology behind sodium retention in heart failure with preserved ejection fraction (HFpEF) remains poorly understood. We hypothesized that patients with HFpEF have impaired natriuresis and diuresis in response to volume expansio…

Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation Open

César A. Romero, Jasmine Lim, Hong Wang, Brandi M. Wynne, Peipei Ma , et al. · 2023

Background N-methyl-D-aspartate receptor (NMDAR) are amino acid receptors that are well studied in brain physiology; however, their role in kidney is poorly understood. Nonetheless, NMDAR inhibitors can increase serum K+ and reduce GFR, wh…

PIP2 Interacts Electrostatically with MARCKS-like Protein-1 and ENaC in Renal Epithelial Cells Open

Qiang Yue, Otor Al‐Khalili, Auriel Moseley, Masaaki Yoshigi, Brandi M. Wynne , et al. · 2022

We examined the interaction of a membrane-associated protein, MARCKS-like Protein-1 (MLP-1), and an ion channel, Epithelial Sodium Channel (ENaC), with the anionic lipid, phosphatidylinositol 4, 5-bisphosphate (PIP2). We found that PIP2 st…

Addressing global disparities in blood pressure control: perspectives of the International Society of Hypertension Open

Aletta E. Schutte, Tazeen H. Jafar, Neil R Poulter, Albertino Damasceno, Nadia Khan , et al. · 2022

Raised blood pressure (BP) is the leading cause of preventable death in the world. Yet, its global prevalence is increasing, and it remains poorly detected, treated, and controlled in both high- and low-resource settings. From the perspect…

Interleukin 6 mediated activation of the mineralocorticoid receptor in the aldosterone-sensitive distal nephron Open

Brandi M. Wynne, Trinity K. Samson, Hayley Catherine Moyer, Henrieke J. van Elst, Auriel Moseley , et al. · 2022

Hypertension is characterized by increased sodium (Na + ) reabsorption along the aldosterone-sensitive distal nephron (ASDN) as well as chronic systemic inflammation. Interleukin-6 (IL-6) is thought to be a mediator of this inflammatory pr…

Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells Open

Chang Eun Song, Qiang Yue, Auriel Moseley, Otor Al‐Khalili, Brandi M. Wynne , et al. · 2020

The epithelial sodium channel (ENaC) regulates blood pressure by fine-tuning distal nephron sodium reabsorption. Our previous work has shown that ENaC gating is regulated by anionic phospholipid phosphates, including phosphatidylinositol 4…

Highlights from the International Society of Hypertension's New Investigators Network during 2019 Open

Ruan Kruger, Mattias Brunström, Dylan Burger, Fadi J. Charchar, Rachel E. Climie , et al. · 2020

The New Investigators Committee (NIC) of the International Society of Hypertension (ISH) is a dynamic group of junior doctors and scientists, actively involved in various society activities. This report highlights the events (scientific me…

Moving the Needle on Hypertension Open

Alissa A. Frame, William B. Farquhar, Marie E. Latulippe, Alicia A. McDonough, Richard D. Wainford , et al. · 2019

This review highlights the gaps in knowledge and methodological challenges discussed during the Experimental Biology 2019 expert panel session titled “Moving the Needle on Hypertension: What Knowledge Is Needed?” Hypertension is a critical…

Highlights From the American Heart Association's Joint Hypertension 2018 Scientific Sessions Open

Brandi M. Wynne, Hana A. Itani · 2019

Blood collection in unstressed, conscious, and freely moving mice through implantation of catheters in the jugular vein: a new simplified protocol Open

Annie Y. Park, Paul M. Plotsky, Truyen D. Pham, Karel Pacák, Brandi M. Wynne , et al. · 2018

The mouse has become the most common mammalian animal model used in biomedical research. However, laboratory techniques used previously in rats and other larger animals to sample blood had to be adapted in mice due to their lower mouse pla…

Report from the NIC: Argentine Society of Hypertension (SAHA) meeting, Buenos Aires Open

César A. Romero, Brandi M. Wynne · 2018

Protein kinase Cα deletion causes hypotension and decreased vascular contractility Open

Brandi M. Wynne, Cameron G. McCarthy, Theodora Szasz, Patrick A. Molina, Arlene B. Chapman , et al. · 2017

Together, these data suggest that global deletion of PKCα results in reduced MAP due to decreased vascular contractility.

Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta Open

Brandi M. Wynne, Hicham Labazi, Zidonia N. Carneiro, Rita C. Tostes, R. Clinton Webb · 2017

Nitroxyl Anion Mediates Relaxation in Mesenteric Arteries from Angiotensin II Hypertensive Mice Open

Brandi M. Wynne, Hicham Labazi, Rita C. Tostes, R. Clinton Webb · 2017

We reveal that exogenous HNO-mediated relaxation, via Angeli's Salt, is impaired in mesenteric arteries from AngII-treated mice, yet endogenous HNO-mediated relaxation may be more important during hypertension.

Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines Open

Brandi M. Wynne, Li Zou, Valerie Linck, Robert S. Hoover, He‐Ping Ma , et al. · 2017

Acute lung injury leading to acute respiratory distress (ARDS) is a global health concern. ARDS patients have significant pulmonary inflammation leading to flooding of the pulmonary alveoli. This prevents normal gas exchange with consequen…

Aldosterone Modulates the Association between NCC and ENaC Open

Brandi M. Wynne, Abinash C. Mistry, Otor Al‐Khalili, Rickta Mallick, Franziska Theilig , et al. · 2017

The sodium chloride cotransporter (NCC) and epithelial sodium channel (ENaC) associate Open

Abinash C. Mistry, Brandi M. Wynne, Ling Yu, Viktor Tomilin, Qiang Yue , et al. · 2016

The thiazide-sensitive sodium chloride cotransporter (NCC) and the epithelial sodium channel (ENaC) are two of the most important determinants of salt balance and thus systemic blood pressure. Abnormalities in either result in profound cha…

Pendrin localizes to the adrenal medulla and modulates catecholamine release Open

Yoskaly Lazo‐Fernandez, Greti Aguilera, Truyen D. Pham, Annie Y. Park, William H. Beierwaltes , et al. · 2015

Pendrin ( Slc26a4) is a Cl − /HCO 3 − exchanger expressed in renal intercalated cells and mediates renal Cl − absorption. With pendrin gene ablation, blood pressure and vascular volume fall, which increases plasma renin concentration. Howe…

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