Mark Crowther
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View article: Andexanet alfa vs standard of care for factor Xa inhibitor-induced intracranial hemorrhage—a systematic review and meta-analysis
Andexanet alfa vs standard of care for factor Xa inhibitor-induced intracranial hemorrhage—a systematic review and meta-analysis Open
View article: ‘Raise the Bar’, a Canadian intervention to combat disparities in the recognition and management of iron deficiency: Development of the intervention, feasibility and implementation
‘Raise the Bar’, a Canadian intervention to combat disparities in the recognition and management of iron deficiency: Development of the intervention, feasibility and implementation Open
View article: Genetic and epigenetic dysregulation of CR1 is associated with catastrophic antiphospholipid syndrome
Genetic and epigenetic dysregulation of CR1 is associated with catastrophic antiphospholipid syndrome Open
View article: Correction: Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor
Correction: Autoantibodies against the cell surface–associated chaperone GRP78 stimulate tumor growth via tissue factor Open
View article: External Validation of the JAKPOT Score for Diagnosing JAK2-Positive Erythrocytosis: A Retrospective Cohort Study
External Validation of the JAKPOT Score for Diagnosing JAK2-Positive Erythrocytosis: A Retrospective Cohort Study Open
Background/Objectives: Erythrocytosis is a common laboratory abnormality affecting approximately 4% of males and 0.4% of females. The JAKPOT score was recently developed to differentiate primary from secondary erythrocytosis without molecu…
View article: Genetic and Epigenetic Dysregulation of CR1 is Associated with Catastrophic Antiphospholipid Syndrome (CAPS)
Genetic and Epigenetic Dysregulation of CR1 is Associated with Catastrophic Antiphospholipid Syndrome (CAPS) Open
Objective Catastrophic antiphospholipid syndrome (CAPS), characterized by widespread thrombosis and multi-organ failure, is associated with high morbidity and mortality. We previously established complement activation as a pathogenic drive…
View article: Assessing the accuracy of ChatGPT responses to guideline-based inquiries: A cross-sectional study
Assessing the accuracy of ChatGPT responses to guideline-based inquiries: A cross-sectional study Open
Introduction: Physicians treating multisystem diseases face challenges in consulting expanding, complex clinical guidelines. Large language models like ChatGPT may help consolidate this information, providing quick access to guideline reco…
View article: A Hyperacute Presentation of Small Cell, Non-Nodal Mantle Cell Lymphoma.
A Hyperacute Presentation of Small Cell, Non-Nodal Mantle Cell Lymphoma. Open
Mantle cell lymphoma (MCL) is an aggressive mature B-cell non-Hodgkin lymphoma. Patients often present with lymphadenopathy, early satiety, and B-symptoms. Presentation with hyperleukocytosis is rare. The small cell, non-nodal variant of M…
View article: Catastrophic antiphospholipid syndrome: a CAPS-tivating hematologic disease
Catastrophic antiphospholipid syndrome: a CAPS-tivating hematologic disease Open
Catastrophic antiphospholipid syndrome (CAPS) is a rare but life-threatening form of antiphospholipid syndrome (APS) defined by the rapid onset of large and small vessel thrombosis occurring simultaneously across multiple sites, resulting …
View article: Safety and efficacy of direct oral anticoagulants in chronic kidney disease: a meta-analysis
Safety and efficacy of direct oral anticoagulants in chronic kidney disease: a meta-analysis Open
In this meta-analysis, DOACs reduced major bleeding compared with VKAs in stage 4, stage 5/renal replacement therapy, and CKD stage unspecified patients. Future analysis should evaluate the impact of specific DOACs and dosage on safety and…
View article: Development of the 2023 <scp>ACR/EULAR</scp> Antiphospholipid Syndrome Classification Criteria, Phase III‐D Report: Multicriteria Decision Analysis
Development of the 2023 <span>ACR/EULAR</span> Antiphospholipid Syndrome Classification Criteria, Phase III‐D Report: Multicriteria Decision Analysis Open
Objective The 2023 American College of Rheumatology/EULAR antiphospholipid syndrome (APS) classification criteria development, which aimed to identify patients with high likelihood of APS for research, employed a four‐phase methodology. Ph…
View article: Efficacy of vitamin C with Fe supplementation in patients with iron deficiency anemia: a systematic review and meta-analysis
Efficacy of vitamin C with Fe supplementation in patients with iron deficiency anemia: a systematic review and meta-analysis Open
Oral iron (Fe) supplementation is one of the mainstays of treatment for iron deficiency anemia (IDA). However, its therapeutic effects are limited when there is poor absorption from the gastrointestinal tract. Vitamin C is hypothesized to …
View article: Fostamatinib for immune thrombocytopenic purpura in adult patients: A systematic review and meta‐analysis
Fostamatinib for immune thrombocytopenic purpura in adult patients: A systematic review and meta‐analysis Open
Immune thrombocytopenic purpura (ITP) is an immune disorder characterized by thrombocytopenia. Fostamatinib is an orally administered spleen tyrosine kinase inhibitor intended to treat refractory ITP. To evaluate the efficacy and safety of…
View article: Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding
Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding Open
Background and purpose The ANNEXA‐4 trial measured hemostatic efficacy of andexanet alfa in patients with major bleeding taking factor Xa inhibitors. A proportion of this was traumatic and nontraumatic intracranial bleeding. Different meas…
View article: Two-year follow-up of the SMR stemless platform shoulder system: a multicenter, prospective clinical study
Two-year follow-up of the SMR stemless platform shoulder system: a multicenter, prospective clinical study Open
View article: The Efficacy and Safety of Andexanet Alfa in Patients With Acute Gastrointestinal Bleeding While Taking Factor Xa Inhibitors: An ANNEXA-4 Subanalysis
The Efficacy and Safety of Andexanet Alfa in Patients With Acute Gastrointestinal Bleeding While Taking Factor Xa Inhibitors: An ANNEXA-4 Subanalysis Open
View article: Low recurrent thrombosis rates in single positive antiphospholipid syndrome regardless of type of anticoagulation
Low recurrent thrombosis rates in single positive antiphospholipid syndrome regardless of type of anticoagulation Open
View article: Anticoagulation for mechanical aortic valves: An international survey of current practice patterns and perceptions
Anticoagulation for mechanical aortic valves: An international survey of current practice patterns and perceptions Open
Introduction: For patients with mechanical aortic valves, guideline recommended INR targets range from 2.0 to 3.5, depending on thromboembolic risk factors. Supporting data is largely historical and of low quality. We aimed to characterize…
View article: A303 SAFETY AND EFFICACY OF DIRECT ORAL ANTICOAGULANTS IN PATIENTS WITH LIVER CIRRHOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS
A303 SAFETY AND EFFICACY OF DIRECT ORAL ANTICOAGULANTS IN PATIENTS WITH LIVER CIRRHOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS Open
Background Direct oral anticoagulants (DOACs) are widely used for treatment of venous thromboembolism (VTE) and stroke prophylaxis in patients with atrial fibrillation. Liver cirrhosis increases the risk of conditions necessitating anticoa…
View article: Primary prevention of venous thromboembolism for cancer patients in randomized controlled trials: a bibliographical analysis of funding and trial characteristics
Primary prevention of venous thromboembolism for cancer patients in randomized controlled trials: a bibliographical analysis of funding and trial characteristics Open
There were few significant differences between trial characteristics, suggesting that the evidence from commercially sponsored trials investigating VTE prophylaxis in patients with cancer is unlikely to be subject to bias attributable to c…
View article: Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care
Small-Volume Blood Collection Tubes to Reduce Transfusions in Intensive Care Open
Importance Blood collection for laboratory testing in intensive care unit (ICU) patients is a modifiable contributor to anemia and red blood cell (RBC) transfusion. Most blood withdrawn is not required for analysis and is discarded. Object…
View article: A new approach to antiphospholipid antibody syndrome
A new approach to antiphospholipid antibody syndrome Open
View article: PB1478 Attributes of Randomized Controlled Trials and Their Associations with Funding Sources in Venous Thromboembolism Prophylaxis for Patients with Cancer: A Bibliographical Analysis
PB1478 Attributes of Randomized Controlled Trials and Their Associations with Funding Sources in Venous Thromboembolism Prophylaxis for Patients with Cancer: A Bibliographical Analysis Open
View article: OC 21.2 Safety of DOACs in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis
OC 21.2 Safety of DOACs in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis Open
View article: PB0485 Use of DOACs in the Management of Upper Extremity Deep Venous Thrombosis: A Systematic Review
PB0485 Use of DOACs in the Management of Upper Extremity Deep Venous Thrombosis: A Systematic Review Open
bleeding.
View article: OC 54.3 Direct Oral Anticoagulants vs Low Molecular Weight Heparin in the Management of Patients with Primary or Metastatic Brain Tumours: A Systematic Review and Meta-Analysis
OC 54.3 Direct Oral Anticoagulants vs Low Molecular Weight Heparin in the Management of Patients with Primary or Metastatic Brain Tumours: A Systematic Review and Meta-Analysis Open
View article: The 2023 <scp>ACR</scp>/<scp>EULAR</scp> Antiphospholipid Syndrome Classification Criteria
The 2023 <span>ACR</span>/<span>EULAR</span> Antiphospholipid Syndrome Classification Criteria Open
Objective To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) and EULAR. Methods This int…
View article: 2023 ACR/EULAR antiphospholipid syndrome classification criteria
2023 ACR/EULAR antiphospholipid syndrome classification criteria Open
View article: PB2045: USE OF ANAKINRA IN THE TREATMENT OF ADULT HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS: A SYSTEMATIC REVIEW
PB2045: USE OF ANAKINRA IN THE TREATMENT OF ADULT HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS: A SYSTEMATIC REVIEW Open
Topic: 12. Bone marrow failure syndromes incl. PNH - Clinical Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome characterized by extreme inflammation and tissue destruction through immune activation of T cells, NK cel…
View article: P1669: DIRECT ORAL ANTICOAGULANTS VS LOW MOLECULAR WEIGHT HEPARIN IN THE MANAGEMENT OF PATIENTS WITH PRIMARY OR METASTATIC BRAIN TUMOURS: A SYSTEMATIC REVIEW AND META-ANALYSIS
P1669: DIRECT ORAL ANTICOAGULANTS VS LOW MOLECULAR WEIGHT HEPARIN IN THE MANAGEMENT OF PATIENTS WITH PRIMARY OR METASTATIC BRAIN TUMOURS: A SYSTEMATIC REVIEW AND META-ANALYSIS Open
Topic: 34. Thrombosis and vascular biology - Biology & Translational Research Background: Patients with primary or metastatic brain tumours are at increased risk of thrombosis like other malignancies. Low-molecular weight heparin (LMWH) is…