Brandon Benefield
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View article: ScarNet: A Novel Foundation Model for Automated Myocardial Scar Quantification from LGE in Cardiac MRI
ScarNet: A Novel Foundation Model for Automated Myocardial Scar Quantification from LGE in Cardiac MRI Open
Background: Late Gadolinium Enhancement (LGE) imaging is the gold standard for assessing myocardial fibrosis and scarring, with left ventricular (LV) LGE extent predicting major adverse cardiac events (MACE). Despite its importance, routin…
View article: ScarNet: a novel foundation model for automated myocardial scar quantification from late gadolinium-enhancement images
ScarNet: a novel foundation model for automated myocardial scar quantification from late gadolinium-enhancement images Open
ScarNet outperformed MedSAM and nnU-Net for predicting myocardial and scar boundaries in LGE images of patients with ischemic cardiomyopathy. The Monte Carlo simulations demonstrated that ScarNet is less sensitive to noise perturbations th…
View article: Use of Atrial Fibrillation Electrograms and T1/T2 Magnetic Resonance Imaging to Define the Progressive Nature of Molecular and Structural Remodeling: A New Paradigm Underlying the Emergence of Persistent Atrial Fibrillation
Use of Atrial Fibrillation Electrograms and T1/T2 Magnetic Resonance Imaging to Define the Progressive Nature of Molecular and Structural Remodeling: A New Paradigm Underlying the Emergence of Persistent Atrial Fibrillation Open
Background The temporal progression states of the molecular and structural substrate in atrial fibrillation (AF) are not well understood. We hypothesized that these can be detected by AF electrograms and magnetic resonance imaging parametr…
View article: Incorporation of view sharing and KWIC filtering into GRASP‐Pro improves spatial resolution of single‐shot, multi‐TI, late gadolinium enhancement MRI
Incorporation of view sharing and KWIC filtering into GRASP‐Pro improves spatial resolution of single‐shot, multi‐TI, late gadolinium enhancement MRI Open
While single‐shot late gadolinium enhancement (LGE) is useful for imaging patients with arrhythmia and/or dyspnea, it produces low spatial resolution. One approach to improve spatial resolution is to accelerate data acquisition using compr…
View article: A theoretical framework for retrospective correction to the arterial input function in quantitative myocardial perfusion MRI
A theoretical framework for retrospective correction to the arterial input function in quantitative myocardial perfusion MRI Open
Purpose To develop and evaluate a flexible, Bloch‐equation based framework for retrospective correction to the arterial input function (AIF) obtained with quantitative cardiac perfusion pulse sequences. Methods Our framework initially calc…
View article: Identification of Cardiac Fibrosis in Young Adults With a Homozygous Frameshift Variant in <i>SERPINE1</i>
Identification of Cardiac Fibrosis in Young Adults With a Homozygous Frameshift Variant in <i>SERPINE1</i> Open
In this study, a highly penetrant, autosomal recessive, cardiac fibrosis phenotype among young adults with homozygous frameshift variant for SERPINE1 was identified, suggesting an optimal range of PAI-1 levels are needed for cardiac homeos…
View article: Attenuation of Oxidative Injury With Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium
Attenuation of Oxidative Injury With Targeted Expression of NADPH Oxidase 2 Short Hairpin RNA Prevents Onset and Maintenance of Electrical Remodeling in the Canine Atrium Open
Background: Atrial fibrillation (AF) is the most common heart rhythm disorder in adults and a major cause of stroke. Unfortunately, current treatments of AF are suboptimal because they are not targeted to the molecular mechanisms underlyin…
View article: Diffuse right ventricular fibrosis in heart failure with preserved ejection fraction and pulmonary hypertension
Diffuse right ventricular fibrosis in heart failure with preserved ejection fraction and pulmonary hypertension Open
Aims While right ventricular (RV) dysfunction is associated with worse prognosis in co‐morbid pulmonary hypertension and heart failure with preserved ejection fraction (PH‐HFpEF), the mechanisms driving RV dysfunction are unclear. We evalu…
View article: Region-specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation
Region-specific parasympathetic nerve remodeling in the left atrium contributes to creation of a vulnerable substrate for atrial fibrillation Open
Atrial fibrillation (AF) is the most common heart rhythm disorder and a major cause of stroke. Unfortunately, current therapies for AF are suboptimal, largely because the molecular mechanisms underlying AF are poorly understood. Since the …
View article: Disruption of NOX2-dependent Oxidative Injury with a Targeted Gene-Therapy Approach Prevents Atrial Fibrillation in a Canine Model
Disruption of NOX2-dependent Oxidative Injury with a Targeted Gene-Therapy Approach Prevents Atrial Fibrillation in a Canine Model Open
Atrial fibrillation is the most common heart rhythm disorder in adults and a major cause of stroke. Unfortunately, current treatments of AF are suboptimal as they are not targeted to the molecular mechanisms underlying AF. In this study, w…
View article: The Kinetics of Circulating Monocyte Subsets and Monocyte-Platelet Aggregates in the Acute Phase of ST-Elevation Myocardial Infarction
The Kinetics of Circulating Monocyte Subsets and Monocyte-Platelet Aggregates in the Acute Phase of ST-Elevation Myocardial Infarction Open
In experimental myocardial infarction (MI), a rise in cell counts of circulating monocyte subsets contributes to impaired myocardial healing and to atherosclerotic plaque destabilization. In humans, the prognostic role of monocyte subsets …