Brandon D. Brown
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View article: High levels of PTPN11 protein are prognostically adverse and independent of mutation status in acute myelogenous leukemia
High levels of PTPN11 protein are prognostically adverse and independent of mutation status in acute myelogenous leukemia Open
INTRODUCTION: Mutations in Protein Tyrosine Phosphatase Non-Receptor Type 11 (PTPN11) occur in ~8% of Acute Myelogenous Leukemia (AML) cases, and confers an adverse prognosis. Almost all PTPN11 mutations result in constitutively active pho…
View article: Extended forequarter amputation of a pediatric chest wall tumor with free flap reconstruction, targeted muscle reinnervation, and 3D-printed model guidance: a case report
Extended forequarter amputation of a pediatric chest wall tumor with free flap reconstruction, targeted muscle reinnervation, and 3D-printed model guidance: a case report Open
Pediatric chest wall tumors are rare, with limited cases documented in the literature. This report presents a rare case of a primitive myxoid mesenchymal tumor of infancy (PMMTI) in a 2-month-old male. The tumor’s rarity, aggressive invasi…
View article: Towards Long-Range, Battery-less Water Leak Detection: A LoRa-Based Approach
Towards Long-Range, Battery-less Water Leak Detection: A LoRa-Based Approach Open
This paper presents a battery-less, self-powered water leak detection system that utilizes LoRa communication for long-range, real-time monitoring. The system harvests hydroelectric energy through a layered stack of conductive nanomaterial…
View article: A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia
A STAT3 Degrader Demonstrates Pre-clinical Efficacy in Venetoclax resistant Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy that continues to have poor prognosis despite recent therapeutic advances. Venetoclax (Ven), a BCL2-inhibitor has shown a high response rate in AML; however, relapse is i…
View article: Proteomics for Optimizing Therapy in Acute Myeloid Leukemia: Venetoclax plus Hypomethylating Agents versus Conventional Chemotherapy
Proteomics for Optimizing Therapy in Acute Myeloid Leukemia: Venetoclax plus Hypomethylating Agents versus Conventional Chemotherapy Open
The use of Hypomethylating agents combined with Venetoclax (VH) for the treatment of Acute Myeloid Leukemia (AML) has greatly improved outcomes in recent years. However not all patients benefit from the VH regimen and a way to rationally s…
View article: Proteomic Profiling Identifies Unique IDH Mutant Signatures and Novel Therapeutic Opportunities in Adult Acute Myeloid Leukemia Patients
Proteomic Profiling Identifies Unique IDH Mutant Signatures and Novel Therapeutic Opportunities in Adult Acute Myeloid Leukemia Patients Open
CONCLUSION Patients with IDH mutations are common in adult Acute Myeloid Leukemia (AML), with selective IDH inhibitors (IDHi) being recommended, but they do not always respond. We evaluated the proteome of IDH mutant AML patients to identi…
View article: Valosin‐containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group
Valosin‐containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group Open
Purpose The endoplasmic reticulum (ER) is the major site of protein synthesis and folding in the cell. ER‐associated degradation (ERAD) and unfolded protein response (UPR) are the main mechanisms of ER‐mediated cell stress adaptation. Targ…
View article: Cash Transfer Apps are a Feasible, Acceptable, and More Equitable Method for Compensating Participants in HIV Research
Cash Transfer Apps are a Feasible, Acceptable, and More Equitable Method for Compensating Participants in HIV Research Open
Campbell, Chadwick K. PhD, MPH; Dubé, Karine DrPH; Sauceda, John A. PhD, MSc; Sevelius, Jae M. PhD; Green-Ajufo, Barbara DrPH; Brown, Brandon PhD, MPH; Ndukwe, Samuel BSPH; Saberi, Parya PharmD, MAS, MFA, AAHIVP Author Information
View article: DNA Damage Response−Related Proteins Are Prognostic for Outcome in Both Adult and Pediatric Acute Myelogenous Leukemia Patients: Samples from Adults and from Children Enrolled in a Children’s Oncology Group Study
DNA Damage Response−Related Proteins Are Prognostic for Outcome in Both Adult and Pediatric Acute Myelogenous Leukemia Patients: Samples from Adults and from Children Enrolled in a Children’s Oncology Group Study Open
The survival of malignant leukemic cells is dependent on DNA damage repair (DDR) signaling. Reverse Phase Protein Array (RPPA) data sets were assembled using diagnostic samples from 810 adult and 500 pediatric acute myelogenous leukemia (A…
View article: Reverse Phase Protein Array Profiling Identifies Recurrent Protein Expression Patterns of DNA Damage-Related Proteins across Acute and Chronic Leukemia: Samples from Adults and the Children’s Oncology Group
Reverse Phase Protein Array Profiling Identifies Recurrent Protein Expression Patterns of DNA Damage-Related Proteins across Acute and Chronic Leukemia: Samples from Adults and the Children’s Oncology Group Open
DNA damage response (DNADR) recognition and repair (DDR) pathways affect carcinogenesis and therapy responsiveness in cancers, including leukemia. We measured protein expression levels of 16 DNADR and DDR proteins using the Reverse Phase P…
View article: Retrospective Review of Flexible Bronchoscopy in Pediatric Cancer Patients
Retrospective Review of Flexible Bronchoscopy in Pediatric Cancer Patients Open
The use of flexible bronchoscopy (FB) with bronchoalveolar lavage (BAL) to diagnose and manage pulmonary complications has been shown to be safe in adult cancer patients, but whether its use is safe in pediatric cancer patients remains unc…
View article: Immune Effector Cell Associated Neurotoxicity (ICANS) in Pediatric and Young Adult Patients Following Chimeric Antigen Receptor (CAR) T-Cell Therapy: Can We Optimize Early Diagnosis?
Immune Effector Cell Associated Neurotoxicity (ICANS) in Pediatric and Young Adult Patients Following Chimeric Antigen Receptor (CAR) T-Cell Therapy: Can We Optimize Early Diagnosis? Open
The Cornell Assessment for Pediatric Delirium (CAPD) was first proposed by the Pediatric Acute Lung Injury and Sepsis Investigators Network-Stem Cell Transplantation and Cancer Immunotherapy Subgroup and MD Anderson CARTOX joint working co…
View article: IMMU-07. IMMUNE EFFECTOR CELL ASSOCIATED NEUROTOXICITY (ICANS) AMONG PEDIATRIC AND AYA PATIENTS: MD ANDERSON CANCER CENTER EXPERIENCE
IMMU-07. IMMUNE EFFECTOR CELL ASSOCIATED NEUROTOXICITY (ICANS) AMONG PEDIATRIC AND AYA PATIENTS: MD ANDERSON CANCER CENTER EXPERIENCE Open
INTRODUCTION Immune effector cell associated neurotoxicity (ICANS) and cytokine release syndrome (CRS) are potentially life-threatening complications associated with immune effector cell (IEC) therapies. We characterize ICANS in pediatric …
View article: IMMU-52. IMMUNE EFFECTOR CELL ASSOCIATED NEUROTOXICITY (ICANS) AMONG PEDIATRIC AND AYA PATIENTS: MD ANDERSON CANCER CENTER EXPERIENCE
IMMU-52. IMMUNE EFFECTOR CELL ASSOCIATED NEUROTOXICITY (ICANS) AMONG PEDIATRIC AND AYA PATIENTS: MD ANDERSON CANCER CENTER EXPERIENCE Open
INTRODUCTION Immune effector cell associated neurotoxicity (ICANS) and cytokine release syndrome (CRS) are potentially life-threatening complications associated with immune effector cell (IEC) therapies. We characterize ICANS in pediatric …
View article: Altered Immunity and Microbial Dysbiosis in Aged Individuals With Long-Term Controlled HIV Infection
Altered Immunity and Microbial Dysbiosis in Aged Individuals With Long-Term Controlled HIV Infection Open
The introduction of highly active antiretroviral therapy (HAART) resulted in a significant increase in life expectancy for HIV patients. Indeed, in 2015, 45% of the HIV+ individuals in the United States were ≥55 years of age. Despite impro…