This paper presents a battery-less, self-powered water leak detection system that utilizes LoRa communication for long-range, real-time monitoring. The system harvests hydroelectric energy through a layered stack of conductive nanomaterials and metals, achieving a peak short-circuit current of over 500 mA and 1.65 V open-circuit voltage upon exposure to water. To address LoRa's higher power demands, an energy management subsystem -- comprising a DC-DC boost converter and a 100 mF supercapacitor -- ensures stable p…

Abstract INTRODUCTION: Mutations in Protein Tyrosine Phosphatase Non-Receptor Type 11 (PTPN11) occur in ~8% of Acute Myelogenous Leukemia (AML) cases, and confers an adverse prognosis. Almost all PTPN11 mutations result in constitutively active phosphatase activity, without changes in the catalytic and target-recognition sites of the protein. Thus, we hypothesized that overexpression of the wild-type (WT) protein could result in the same phenotype as the mutant (MUT) PTPN11 and confer a similarly adverse prognosis…

Pediatric chest wall tumors are rare, with limited cases documented in the literature. This report presents a rare case of a primitive myxoid mesenchymal tumor of infancy (PMMTI) in a 2-month-old male. The tumor’s rarity, aggressive invasion into the chest wall, and patient’s age posed significant challenges in determining an optimal treatment plan that balanced complete resection with future developmental considerations. After neoadjuvant chemotherapy, the patient underwent an extended forequarter amputation (EFQ…

Abstract Acute myeloid leukemia (AML) is an aggressive hematologic malignancy that continues to have poor prognosis despite recent therapeutic advances. Venetoclax (Ven), a BCL2-inhibitor has shown a high response rate in AML; however, relapse is invariable due to mitochondrial dysregulation that includes upregulation of the antiapoptotic protein MCL1, a central mechanism of Ven resistance (Ven-res). We have previously demonstrated that the transcription factor STAT3 is upregulated in AML hematopoietic stem and pr…

The survival of malignant leukemic cells is dependent on DNA damage repair (DDR) signaling. Reverse Phase Protein Array (RPPA) data sets were assembled using diagnostic samples from 810 adult and 500 pediatric acute myelogenous leukemia (AML) patients and were probed with 412 and 296 strictly validated antibodies, respectively, including those detecting the expression of proteins directly involved in DDR. Unbiased hierarchical clustering identified strong recurrent DDR protein expression patterns in both adult and…