Brandon Hollingsworth
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View article: Spatial and clinical epidemiology of spotted fever rickettsioses and ehrlichiosis, North Carolina, 2010-2019.
Spatial and clinical epidemiology of spotted fever rickettsioses and ehrlichiosis, North Carolina, 2010-2019. Open
BACKGROUND: North Carolina (NC) ranks among the top five states for spotted fever rickettsiosis (SFR) cases and second for ehrlichiosis in the U.S. Identifying geographic clusters of cases is important to elucidate disease risk and inform …
View article: Spatial and clinical epidemiology of spotted fever rickettsioses and ehrlichiosis, North Carolina, 2010–2019
Spatial and clinical epidemiology of spotted fever rickettsioses and ehrlichiosis, North Carolina, 2010–2019 Open
Background North Carolina (NC) ranks among the top five states for spotted fever rickettsiosis (SFR) cases and second for ehrlichiosis in the U.S. Identifying geographic clusters of cases is important to elucidate disease risk and inform p…
View article: Beyond temperature: Relative humidity systematically shifts the temperature dependence of population growth in a malaria vector
Beyond temperature: Relative humidity systematically shifts the temperature dependence of population growth in a malaria vector Open
Understanding ectotherm responses to environmental change is central to coping with many of humanity’s current and future challenges in public health, biodiversity conservation, and food security. Complex relationships between abiotic and …
View article: Field-validation of multiple species distribution models shows variation in performance for predicting <i>Aedes albopictus</i> distributions at the invasion edge
Field-validation of multiple species distribution models shows variation in performance for predicting <i>Aedes albopictus</i> distributions at the invasion edge Open
Climate and land use changes have resulted in range expansion of many species. In this shifting disease landscape, it is important to leverage tools that can predict the potential distributions of invading vectors to target surveillance an…
View article: Environmental risk and Alpha-gal Syndrome (AGS) in the Mid-Atlantic United States
Environmental risk and Alpha-gal Syndrome (AGS) in the Mid-Atlantic United States Open
Alpha-gal syndrome (AGS), commonly referred to as the tick bite red meat allergy, has been reported worldwide with the number of suspected cases in the United States increasing from 24 in 2009 to over 34,000 in 2019. Within the US, AGS is …
View article: Comparison of commercially available, rapid, point-of-care C-reactive protein assays among children with febrile illness in southwestern Uganda
Comparison of commercially available, rapid, point-of-care C-reactive protein assays among children with febrile illness in southwestern Uganda Open
In Uganda, children with febrile illness are often treated with antibiotics even though most have self-limiting, likely viral, infections. C-reactive protein (CRP) measurement can help identify those who are more likely to have a bacterial…
View article: Comparison of commercially available, rapid, point-of-care C-reactive protein assays among children with febrile illness in southwestern Uganda
Comparison of commercially available, rapid, point-of-care C-reactive protein assays among children with febrile illness in southwestern Uganda Open
In Uganda, children with febrile illness are often treated with antibiotics even though most have self-limiting, likely viral, infections. C-reactive protein (CRP) measurement can help identify those who are more likely to have a bacterial…
View article: The effect of governance structures on optimal control of two-patch epidemic models
The effect of governance structures on optimal control of two-patch epidemic models Open
Infectious diseases continue to pose a significant threat to the health of humans globally. While the spread of pathogens transcends geographical boundaries, the management of infectious diseases typically occurs within distinct spatial un…
View article: Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics
Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics Open
Several aspects of mosquito ecology that are important for vectored disease transmission and control have been difficult to measure at epidemiologically important scales in the field. In particular, the ability to describe mosquito populat…
View article: Evolution of Spatial Risk of Malaria Infection After a Pragmatic Chemoprevention Program in Response to Severe Flooding in Rural Western Uganda
Evolution of Spatial Risk of Malaria Infection After a Pragmatic Chemoprevention Program in Response to Severe Flooding in Rural Western Uganda Open
Background Malaria epidemics result from extreme precipitation and flooding, which are increasing with global climate change. Local adaptation and mitigation strategies will be essential to prevent excess morbidity and mortality. Methods W…
View article: Comparing field-collected versus remotely-sensed variables to model malaria risk in the highlands of western Uganda
Comparing field-collected versus remotely-sensed variables to model malaria risk in the highlands of western Uganda Open
Background Malaria risk is not uniform across relatively small geographic areas, such as within a village. This heterogeneity in risk is associated with factors including demographic characteristics, individual behaviours, home constructio…
View article: Evaluation of an open forecasting challenge to assess skill of West Nile virus neuroinvasive disease prediction
Evaluation of an open forecasting challenge to assess skill of West Nile virus neuroinvasive disease prediction Open
View article: Evaluation of an open forecasting challenge to assess skill of West Nile virus neuroinvasive disease prediction
Evaluation of an open forecasting challenge to assess skill of West Nile virus neuroinvasive disease prediction Open
Background: West Nile virus (WNV) is the leading cause of mosquito-borne illness in the continental United States. WNV occurrence has high spatiotemporal variation and current approaches for targeted control of the virus are limited, makin…
View article: Patterns of Testing for Tick-Borne Diseases and Implications for Surveillance in the Southeastern US
Patterns of Testing for Tick-Borne Diseases and Implications for Surveillance in the Southeastern US Open
In this cross-sectional study, most of the patients suspected of having TBD did not have testing performed in accordance with established guidelines, which substantially limits understanding of TBD epidemiology. Furthermore, the data revea…
View article: Effectiveness of autocidal gravid trapping and chemical control in altering abundance and age structure of <i>Aedes albopictus</i>
Effectiveness of autocidal gravid trapping and chemical control in altering abundance and age structure of <i>Aedes albopictus</i> Open
Background Aedes albopictus is a nuisance pest mosquito of public health importance commonly managed with adulticides and larvicides. We investigated whether adding Gravid Aedes Traps (GATs), Autocidal Gravid Ovitraps (AGOs) or In2Care tra…
View article: “Half the truth is often a great lie:” testing for tick-borne diseases and implications for surveillance
“Half the truth is often a great lie:” testing for tick-borne diseases and implications for surveillance Open
Importance Tick-borne diseases (TBD) including Spotted Fever Group Rickettsiosis (SFGR), ehrlichiosis, and increasingly Lyme disease represent a substantial public health concern throughout much of the Southeastern United States. Yet, ther…
View article: Finding mutations in all the wrong places: Prevalence of knock-down resistance F1534S mutations among <i>Aedes albopictus (family: Culicidae, order: Diptera)</i> in North Carolina
Finding mutations in all the wrong places: Prevalence of knock-down resistance F1534S mutations among <i>Aedes albopictus (family: Culicidae, order: Diptera)</i> in North Carolina Open
Background Knock-down resistance ( kdr ) mutations in the voltage gated sodium channel gene of Aedes species mosquitoes are biomarkers for resistance to pyrethroid insecticides. In the United States, few studies have reported kdr mutations…
View article: Dihydroartemisinin-Piperaquine Chemoprevention and Malaria Incidence After Severe Flooding: Evaluation of a Pragmatic Intervention in Rural Uganda
Dihydroartemisinin-Piperaquine Chemoprevention and Malaria Incidence After Severe Flooding: Evaluation of a Pragmatic Intervention in Rural Uganda Open
Background Malaria epidemics are a well-described phenomenon after extreme precipitation and flooding. Yet, few studies have examined mitigation measures to prevent post-flood malaria epidemics. Methods We evaluated a malaria chemopreventi…
View article: After the honeymoon, the divorce: Unexpected outcomes of disease control measures against endemic infections
After the honeymoon, the divorce: Unexpected outcomes of disease control measures against endemic infections Open
The lack of effective vaccines for many endemic diseases often forces policymakers to rely on non-immunizing control measures, such as vector control, to reduce the massive burden of these diseases. Controls can have well-known counterintu…
View article: Evaluating Aedes-vectored Disease Control: Risks and New Approaches.
Evaluating Aedes-vectored Disease Control: Risks and New Approaches. Open
View article: Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Trial
Clofazimine for Treatment of Cryptosporidiosis in Human Immunodeficiency Virus Infected Adults: An Experimental Medicine, Randomized, Double-blind, Placebo-controlled Phase 2a Trial Open
Background We evaluated the efficacy, pharmacokinetics (PK), and safety of clofazimine (CFZ) in patients living with human immunodeficiency virus (HIV) with cryptosporidiosis. Methods We performed a randomized, double-blind, placebo-contro…
View article: Efficacy and Spatial Extent of Yard-Scale Control of <i>Aedes (Stegomyia) albopictus</i> (Diptera: Culicidae) Using Barrier Sprays and Larval Habitat Management
Efficacy and Spatial Extent of Yard-Scale Control of <i>Aedes (Stegomyia) albopictus</i> (Diptera: Culicidae) Using Barrier Sprays and Larval Habitat Management Open
The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), is a peridomestic, container-ovipositing mosquito commonly found throughout the southeastern United States. In the United States, Ae. albopictus is typically considered a nuis…
View article: Short-Term, Large-Area Survey of Container <i>Aedes spp.</i> (Diptera: Culicidae): Presence and Abundance is Associated with Fine-scale Landscape Factors in North Carolina, USA
Short-Term, Large-Area Survey of Container <i>Aedes spp.</i> (Diptera: Culicidae): Presence and Abundance is Associated with Fine-scale Landscape Factors in North Carolina, USA Open
Container Aedes mosquitoes are responsible for the transmission of anthroponotic and zoonotic viruses to people. The surveillance and control of these mosquitoes is an important part of public health protection and prevention of mosquito-b…
View article: Locally Fixed Alleles: A method to localize gene drive to island populations
Locally Fixed Alleles: A method to localize gene drive to island populations Open
Invasive species pose a major threat to biodiversity on islands. While successes have been achieved using traditional removal methods, such as toxicants aimed at rodents, these approaches have limitations and various off-target effects on …
View article: After the honeymoon, the divorce: unexpected outcomes of disease control measures against endemic infections
After the honeymoon, the divorce: unexpected outcomes of disease control measures against endemic infections Open
The lack of effective vaccines for many endemic diseases often forces policymakers to enact control programs that rely on non-immunizing controls, such as vector control, in order to reduce the massive burden of these diseases. It is well …
View article: Locally Fixed Alleles: A method to localize gene drive to island populations
Locally Fixed Alleles: A method to localize gene drive to island populations Open
Invasive species pose a major threat to biodiversity on islands. While successes have been achieved using traditional removal methods, such as toxicants aimed at rodents, these approaches have limitations and various off-target effects on …