Brandon G. Rocque
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View article: Integrative genomics elucidates the evolutionary, temporal, and developmental origins of a hydrocephalus risk gene
Integrative genomics elucidates the evolutionary, temporal, and developmental origins of a hydrocephalus risk gene Open
Introduction A prior integrative, multi-omics human genetics and functional genomics study identified maelstrom ( MAEL ), a gene involved in regulation of DNA transposon activity and genome structure, as a transcriptome-wide predictor of h…
View article: Stereotactic radiosurgery treatment of pediatric arteriovenous malformations: a PRISMA systematic review and meta-analysis
Stereotactic radiosurgery treatment of pediatric arteriovenous malformations: a PRISMA systematic review and meta-analysis Open
Background Stereotactic radiosurgery (SRS) is considered a safe definitive treatment for pediatric arteriovenous malformations (AVMs) upon indicated presentations. There are no published guidelines by the International Stereotactic Radiosu…
View article: Complex shunt system comparison: an observational study by the Hydrocephalus Clinical Research Network
Complex shunt system comparison: an observational study by the Hydrocephalus Clinical Research Network Open
OBJECTIVE Treatment of multiloculated hydrocephalus can require multiple procedures and shunt catheters. This study aimed to determine whether there are differences in shunt survival or complications in patients with complex shunt systems …
View article: Comparison of failure rates between full-barium and striped barium distal shunt catheters: a matched case–control study
Comparison of failure rates between full-barium and striped barium distal shunt catheters: a matched case–control study Open
Purpose We hypothesize that distal shunt catheters fully impregnated with barium are more prone to failure compared to distal catheters with only a barium stripe. We sought to evaluate this distinction using a matched case–control study. M…
View article: Development and content validation of a survey assessing domains of sexual and reproductive health in adults with spina bifida
Development and content validation of a survey assessing domains of sexual and reproductive health in adults with spina bifida Open
Purpose Individuals with spina bifida (SB) often face substantial gaps in sexual and reproductive health (SRH) knowledge leading to low use of contraception, poor utilization of preventative sexual health care, unintended pregnancies, miss…
View article: Transition mentorship for spina bifida patients with the JUMP program: a pilot study
Transition mentorship for spina bifida patients with the JUMP program: a pilot study Open
OBJECTIVE The transition from pediatric to adult care is challenging for patients and families with spina bifida (SB). Lifelong care relationships yield to new care environments that are typically larger, less personal, and less engaged wi…
View article: The role of a dedicated transition process from pediatric to adult interdisciplinary care for persons with spina bifida
The role of a dedicated transition process from pediatric to adult interdisciplinary care for persons with spina bifida Open
OBJECTIVE Interdisciplinary care and pediatric to adult transitional programs have consistently shown medical and social value for individuals with complex medical conditions such as spina bifida (SB). Such interdisciplinary clinics are co…
View article: Neurosurgical management of Myelomeningocele in premature infants: a case series
Neurosurgical management of Myelomeningocele in premature infants: a case series Open
Introduction Myelomeningocele (MMC) is the most common neural tube defect, but rarely seen in premature infants. Most centers advocate for closure of MMC within 24 h of birth. However, this is not always possible in severely premature infa…
View article: Comparing ventriculoatrial and ventriculopleural shunts in pediatric hydrocephalus: a Hydrocephalus Clinical Research Network study
Comparing ventriculoatrial and ventriculopleural shunts in pediatric hydrocephalus: a Hydrocephalus Clinical Research Network study Open
OBJECTIVE When the peritoneal cavity cannot serve as the distal shunt terminus, nonperitoneal shunts, typically terminating in the atrium or pleural space, are used. The comparative effectiveness of these two terminus options has not been …
View article: Body Composition and Energy Expenditure in Youth With Spina Bifida: Protocol for a Multisite, Cross-Sectional Study
Body Composition and Energy Expenditure in Youth With Spina Bifida: Protocol for a Multisite, Cross-Sectional Study Open
Background Obesity prevalence in youth with spina bifida is higher than in their typically developing peers. Obesity is associated with lifelong medical, psychological, and economic burdens. Successful prevention or treatment of obesity in…
View article: RADT-08. BASAL GANGLIA TOXICITY FOLLOWING PROTON THERAPY OF THE PINEAL REGION WITH BILATERAL ACTION-INDUCED MYOCLONUS
RADT-08. BASAL GANGLIA TOXICITY FOLLOWING PROTON THERAPY OF THE PINEAL REGION WITH BILATERAL ACTION-INDUCED MYOCLONUS Open
INTRODUCTION We sought to evaluate the toxicity profile for children receiving 54Gy to the pineal region with a significant dose delivered to posterior thalamus and basal ganglia. METHODS We performed a retrospective review of patients tre…
View article: Predicting the Presence of 4th Ventricular Outlet Obstruction in Chiari I Malformation
Predicting the Presence of 4th Ventricular Outlet Obstruction in Chiari I Malformation Open
Introduction A subset of children with Chiari 1 malformation (CM-1) have a 4th ventricle arachnoid veil—a thin membrane covering the outlet of the 4th ventricle. Studies suggest that failure to disrupt this veil during posterior fossa deco…
View article: Endoluminal Biopsy for Vein of Galen Malformation
Endoluminal Biopsy for Vein of Galen Malformation Open
BACKGROUND AND OBJECTIVES: Vein of Galen malformation (VOGM), the result of arteriovenous shunting between choroidal and/or subependymal arteries and the embryologic prosencephalic vein, is among the most severe cerebrovascular disorders o…
View article: Evaluation of multidisciplinary high-risk pregnancy clinic for myelomeningocele
Evaluation of multidisciplinary high-risk pregnancy clinic for myelomeningocele Open
Introduction A cross-sectional study retrospectively evaluating the perceived usefulness of attending a multi-disciplinary, roundtable, educational prenatal clinic for mothers expecting children with myelomeningocele is presented. Methods …
View article: Ventricular catheter tissue obstruction and shunt malfunction in 9 hydrocephalus etiologies
Ventricular catheter tissue obstruction and shunt malfunction in 9 hydrocephalus etiologies Open
OBJECTIVE Hydrocephalus is a neurological disorder with an incidence of 80–125 per 100,000 births in the United States. The most common treatment, ventricular shunting, has a failure rate of up to 85% within 10 years of placement. The auth…
View article: Neurosurgical Management of Myelomeningocele in Premature Infants: A Case Series
Neurosurgical Management of Myelomeningocele in Premature Infants: A Case Series Open
Introduction Myelomeningocele (MMC) is the most common neural tube defect, but rarely seen in premature infants. Most centers advocate for closure of MMC within 24 hours of birth. However, this is not always possible in severely premature …
View article: Pediatric non-galenic pial arteriovenous fistula’s characteristics and outcomes: a systematic review
Pediatric non-galenic pial arteriovenous fistula’s characteristics and outcomes: a systematic review Open
Introduction Pediatric non-galenic pial arteriovenous fistulas (pAVFs) are rare vascular malformations that are characterized by a pial arterial-venous connection without an intervening capillary bed. Outcomes and treatment strategies for …
View article: The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact
The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact Open
Hydrocephalus (HC) is a heterogenous disease characterized by alterations in cerebrospinal fluid (CSF) dynamics that may cause increased intracranial pressure. HC is a component of a wide array of genetic syndromes as well as a secondary c…
View article: Evaluation of multidisciplinary high-risk pregnancy clinic for myelomeningocele
Evaluation of multidisciplinary high-risk pregnancy clinic for myelomeningocele Open
A cross-sectional study retrospectively evaluating the perceived usefulness of attending a multi-disciplinary, roundtable, educational prenatal clinic for mothers expecting children with myelomeningocele is presented. Mothers who currently…
View article: A re-evaluation of the Endoscopic Third Ventriculostomy Success Score: a Hydrocephalus Clinical Research Network study
A re-evaluation of the Endoscopic Third Ventriculostomy Success Score: a Hydrocephalus Clinical Research Network study Open
OBJECTIVE The Hydrocephalus Clinical Research Network (HCRN) conducted a prospective study 1) to determine if a new, better-performing version of the Endoscopic Third Ventriculostomy Success Score (ETVSS) could be developed, 2) to explore …
View article: The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact
The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact Open
Hydrocephalus (HC) is a heterogenous disease characterized by alterations in cerebrospinal fluid (CSF) dynamics that may cause increased intracranial pressure. HC is a component of a wide array of genetic syndromes as well as a secondary c…
View article: Endothelial sampling<i>in situ</i>enables genetic characterization of vein of Galen Malformation
Endothelial sampling<i>in situ</i>enables genetic characterization of vein of Galen Malformation Open
Background and Objectives Vein of Galen malformation (VOGM), the result of arteriovenous shunting between choroidal and/or subependymal arteries and the embryologic prosencephalic vein, is among the most severe cerebrovascular disorders of…
View article: Impact of Spina Bifida on Sleep Quality: Current Insights
Impact of Spina Bifida on Sleep Quality: Current Insights Open
Spina bifida (SB) is one of the most common birth defects in children. The care for patients with SB continues to evolve, and there has been notable improvement in survival outcomes, degree of disability and quality of life for these child…