G. Brandon Gunn
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View article: Lenvatinib plus pembrolizumab for the Treatment of Patients With Non-BRAF mutated Anaplastic Thyroid Cancer: A single center, phase 2 clinical trial
Lenvatinib plus pembrolizumab for the Treatment of Patients With Non-BRAF mutated Anaplastic Thyroid Cancer: A single center, phase 2 clinical trial Open
Background Dabrafenib (BRAF inhibitor) plus trametinib (MEK inhibitor) are approved for BRAF V600E-mutated anaplastic thyroid cancer (ATC), but ∼60% of tumors do not harbor BRAF V600E, leaving these patients without effective treatment opt…
View article: Superconductivity suppression and bilayer decoupling in Pr substituted YBa$_2$Cu$_3$O$_{7-δ}$
Superconductivity suppression and bilayer decoupling in Pr substituted YBa$_2$Cu$_3$O$_{7-δ}$ Open
The mechanism behind superconductivity suppression induced by Pr substitutions in YBa$_2$Cu$_3$O$_{7-δ}$ (YBCO) has been a mystery since its discovery: in spite of being isovalent to Y$^{3+}$ with a small magnetic moment, it is the only ra…
View article: Segmental Tracheal Resection for Thyroid Cancer: Perioperative Morbidity, Locoregional Control, and Survival
Segmental Tracheal Resection for Thyroid Cancer: Perioperative Morbidity, Locoregional Control, and Survival Open
Background Segmental tracheal resection is rarely needed for advanced thyroid cancer but is among the most complex, high‐risk thyroid surgeries. Methods Retrospective study of patients undergoing segmental tracheal resection for thyroid ca…
View article: Designing an Electronic Patient-Reported Outcomes Information Infrastructure Supported by the RE-AIM Implementation Framework
Designing an Electronic Patient-Reported Outcomes Information Infrastructure Supported by the RE-AIM Implementation Framework Open
Objective: Patient-reported outcomes (PROs) contain valuable information that can be leveraged by providers to perform timely interventions and improve quality of life and survival. However, the implementation of electronic PROs (ePROs) re…
View article: Machine learning predicting acute pain and opioid dose in radiation treated oropharyngeal cancer patients
Machine learning predicting acute pain and opioid dose in radiation treated oropharyngeal cancer patients Open
Introduction Acute pain is common among oral cavity/oropharyngeal cancer (OCC/OPC) patients undergoing radiation therapy (RT). This study aimed to predict acute pain severity and opioid doses during RT using machine learning (ML), facilita…
View article: Designing an Electronic Patient Reported Outcomes Information Infrastructure Supported by the RE-AIM Implementation Framework
Designing an Electronic Patient Reported Outcomes Information Infrastructure Supported by the RE-AIM Implementation Framework Open
Objective Patient-reported outcomes (PROs) contain valuable information that can be leveraged by providers to perform timely interventions and improve quality of life and survival. However, the implementation of electronic PROs (ePROs) rem…
View article: International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation
International multispecialty expert physician preoperative identification of extranodal extension in patients with oropharyngeal cancer using computed tomography: Prospective blinded human inter‐observer performance evaluation Open
Background Pathologic extranodal extension (pENE) is a crucial prognostic factor in oropharyngeal cancer (OPC), but determining pENE from imaging has high inter‐observer variability. The role of clinician specialty in the accuracy of imagi…
View article: Adjuvant pembrolizumab after upfront multimodal therapy for stage IVB Anaplastic Thyroid Cancer
Adjuvant pembrolizumab after upfront multimodal therapy for stage IVB Anaplastic Thyroid Cancer Open
Background ATC has historically been almost uniformly fatal. In patients with loco-regional disease (stage IVB), multimodal therapy (upfront surgery when feasible, radiation +/-concurrent chemotherapy) followed by observation is the curren…
View article: Advanced External Beam Stereotactic Radiotherapy for Skull Base Reirradiation
Advanced External Beam Stereotactic Radiotherapy for Skull Base Reirradiation Open
Background/Objectives: Stereotactic body radiation therapy (SBRT) for skull base reirradiation is particularly challenging, as patients have already received substantial radiation doses to the region, and nearby normal organs may have appr…
View article: Supplementary Table S2 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Supplementary Table S2 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Representativeness of Study Participants
View article: Data from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Data from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Purpose:Outcomes after primary surgery for advanced sinonasal squamous cell carcinoma (SCC) are poor. We tested whether induction chemotherapy (IC) can improve disease control or organ preservation.Patients and Methods:A phase II trial eva…
View article: Supplementary Figure S2 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Supplementary Figure S2 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Imaging with Induction
View article: Supplementary Data S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Supplementary Data S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Protocol
View article: Supplementary Figure S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Supplementary Figure S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Trial Schema
View article: Supplementary Table S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma
Supplementary Table S1 from Phase II Trial of Induction Chemotherapy for Advanced Sinonasal Squamous Cell Carcinoma Open
Patient Clinical and Pathologic Characteristics
View article: Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar squamous cell carcinoma survivors: a cross-sectional internally-matched carotid isodose analysis
Detection of alteration in carotid artery volumetry using standard-of-care computed tomography surveillance scans following unilateral radiation therapy for early-stage tonsillar squamous cell carcinoma survivors: a cross-sectional internally-matched carotid isodose analysis Open
View article: Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer
Patterns of loco-regional progression and patient outcomes after definitive-dose radiation therapy for anaplastic thyroid cancer Open
Despite an intensive treatment schedule, including AF and concurrent chemotherapy, classic radio-resistant and rapid Type A failures predominated; isolated extraneous dose failures were rare. While these findings support the IMRT and TV de…
View article: Anti–Programmed Death Ligand 1 Plus Targeted Therapy in Anaplastic Thyroid Carcinoma
Anti–Programmed Death Ligand 1 Plus Targeted Therapy in Anaplastic Thyroid Carcinoma Open
Importance Anaplastic thyroid carcinoma (ATC) is a rare and lethal cancer. Although progress has been made in recent years in patients with mutated BRAF tumors, those who respond initially eventually die of their disease; furthermore, ther…
View article: Local strain inhomogeneities during electrical triggering of a metal–insulator transition revealed by X-ray microscopy
Local strain inhomogeneities during electrical triggering of a metal–insulator transition revealed by X-ray microscopy Open
Electrical triggering of a metal–insulator transition (MIT) often results in the formation of characteristic spatial patterns such as a metallic filament percolating through an insulating matrix or an insulating barrier splitting a conduct…
View article: A SYNCHROTRON-BASED PROTON THERAPY SYSTEM WITH A CUSTOM DESIGNED NOZZLE AND IMAGING SYSTEMS
A SYNCHROTRON-BASED PROTON THERAPY SYSTEM WITH A CUSTOM DESIGNED NOZZLE AND IMAGING SYSTEMS Open
View article: Comparison of Machine Leaning Models for Prediction of Acute Pain Severity and On-Treatment Opioid Utilization in Oral Cavity and Oropharyngeal Cancer Patients Receiving Radiation Therapy: Exploratory Analysis from a Large-Scale Retrospective Cohort
Comparison of Machine Leaning Models for Prediction of Acute Pain Severity and On-Treatment Opioid Utilization in Oral Cavity and Oropharyngeal Cancer Patients Receiving Radiation Therapy: Exploratory Analysis from a Large-Scale Retrospective Cohort Open
Background Acute pain is a common and debilitating symptom experienced by oral cavity and oropharyngeal cancer (OC/OPC) patients undergoing radiation therapy (RT). Uncontrolled pain can result in opioid overuse and increased risks of long-…
View article: Lacrimal Gland Adenocarcinoma Clinicopathologic Features and Outcomes Compared With Those of Lacrimal Gland Adenoid Cystic Carcinoma
Lacrimal Gland Adenocarcinoma Clinicopathologic Features and Outcomes Compared With Those of Lacrimal Gland Adenoid Cystic Carcinoma Open
Purpose: Lacrimal gland (LG) adenocarcinomas (ACs) are rare, with limited data. We compared clinicopathologic features and local recurrence, distant metastasis, and survival rates between LG AC and LG adenoid cystic carcinoma (ACC). Method…
View article: Detection of Alteration in Carotid Artery Volumetry Using Standard-of-care Computed Tomography Surveillance Scans Following Unilateral Radiation Therapy for Early-stage Tonsillar Squamous Cell Carcinoma Survivors: A Cross-Sectional Internally-Matched Carotid Isodose Analysis
Detection of Alteration in Carotid Artery Volumetry Using Standard-of-care Computed Tomography Surveillance Scans Following Unilateral Radiation Therapy for Early-stage Tonsillar Squamous Cell Carcinoma Survivors: A Cross-Sectional Internally-Matched Carotid Isodose Analysis Open
Purpose Radiation induced carotid artery disease (RICAD) is a major cause of morbidity and mortality among survivors of oropharyngeal cancer. This study leveraged standard-of-care CT scans to detect volumetric changes in the carotid arteri…
View article: Patterns of failure for recurrent head and neck squamous cell carcinoma treated with salvage surgery and postoperative IMRT reirradiation
Patterns of failure for recurrent head and neck squamous cell carcinoma treated with salvage surgery and postoperative IMRT reirradiation Open
View article: Local strain inhomogeneities during the electrical triggering of a metal-insulator transition revealed by the x-ray microscopy
Local strain inhomogeneities during the electrical triggering of a metal-insulator transition revealed by the x-ray microscopy Open
Electrical triggering of a metal-insulator transition (MIT) often results in the formation of characteristic spatial patterns such as a metallic filament percolating through an insulating matrix or an insulating barrier splitting a conduct…
View article: Definitive Radiotherapy for Oligometastatic and Oligoprogressive Thyroid Cancer
Definitive Radiotherapy for Oligometastatic and Oligoprogressive Thyroid Cancer Open
View article: Clinical Acceptability of Automatically Generated Elective Lymph Node Volumes for Head and Neck Cancer Patients
Clinical Acceptability of Automatically Generated Elective Lymph Node Volumes for Head and Neck Cancer Patients Open
View article: Hypothyroidism following Radiotherapy for Head and Neck Cancer: A Systematic Review of the Literature and Opportunities to Improve the Therapeutic Ratio
Hypothyroidism following Radiotherapy for Head and Neck Cancer: A Systematic Review of the Literature and Opportunities to Improve the Therapeutic Ratio Open
(1) Background: Radiotherapy (RT) is a central component for the treatment of many head and neck cancers. In this systematic review of the literature, we aimed to characterize and quantify the published evidence on RT-related hypothyroidis…
View article: Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study
Temporal characterization of acute pain and toxicity kinetics during radiation therapy for head and neck cancer. A retrospective study Open
View article: Patterns of Failure for Recurrent Head and Neck Squamous Cell Carcinoma Treated with Salvage Surgery and Postoperative IMRT Reirradiation
Patterns of Failure for Recurrent Head and Neck Squamous Cell Carcinoma Treated with Salvage Surgery and Postoperative IMRT Reirradiation Open
Purpose/Objectives Determining the optimal postoperative reirradiation volume following salvage surgery for recurrent head and neck squamous cell cancer (HNSCC) is critical given the significant risk of severe reirradiation toxicity and ne…