Barbara Klein
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View article: SHAPE-based chemical probes for studying preQ<sub>1</sub>-RNA interactions in living bacteria
SHAPE-based chemical probes for studying preQ<sub>1</sub>-RNA interactions in living bacteria Open
Interrogating RNA-small molecule interactions inside cells is critical for advancing RNA-targeted drug discovery. In particular, chemical probing technologies that both identify small molecule-bound RNAs and define their binding sites in t…
View article: CRISPR RiPCA for Investigating eIF4E-m<sup>7</sup>GpppX Capped mRNA Interactions
CRISPR RiPCA for Investigating eIF4E-m<sup>7</sup>GpppX Capped mRNA Interactions Open
Post-transcriptional modifications expand the information encoded by an mRNA. These dynamic and reversible modifications are specifically recognized by reader RNA-binding proteins (RBPs), which mediate the regulation of gene expression, RN…
View article: Modified human mesenchymal stromal/stem cells restore cortical excitability after focal ischemic stroke in rats
Modified human mesenchymal stromal/stem cells restore cortical excitability after focal ischemic stroke in rats Open
Allogeneic modified bone marrow-derived human mesenchymal stromal/stem cells (hMSC-SB623 cells) are in clinical development for the treatment of chronic motor deficits after traumatic brain injury and cerebral ischemic stroke. However, the…
View article: The influence of government-issued lockdowns during the COVID-19 pandemic on traumatic brain injuries in Tyrol, Austria
The influence of government-issued lockdowns during the COVID-19 pandemic on traumatic brain injuries in Tyrol, Austria Open
The various governmental measures restricting mobility aimed to contain the COVID-19 pandemic but showed little influence on the number of TBI cases. Only a lockdown in the accident-prone winter months has influenced the incidence of TBIs.
View article: Allergy-induced systemic inflammation impairs tendon quality
Allergy-induced systemic inflammation impairs tendon quality Open
View article: Allergy-induced systemic inflammation impairs tendon quality
Allergy-induced systemic inflammation impairs tendon quality Open
Treatment of tendinopathies still present a major challenge, since the aetiology of the disease remains poorly understood. To determine whether the systemic inflammation accompanying predisposing factors including rheumatoid arthritis, dia…
View article: DCX+ neuronal progenitors contribute to new oligodendrocytes during remyelination in the hippocampus
DCX+ neuronal progenitors contribute to new oligodendrocytes during remyelination in the hippocampus Open
View article: The influence of the COVID-19 pandemic on traumatic brain injuries in Tyrol: experiences from a state under lockdown
The influence of the COVID-19 pandemic on traumatic brain injuries in Tyrol: experiences from a state under lockdown Open
View article: Severe pressure ulcers requiring surgery impair the functional outcome after acute spinal cord injury
Severe pressure ulcers requiring surgery impair the functional outcome after acute spinal cord injury Open
View article: Age Influences Microglial Activation After Cuprizone-Induced Demyelination
Age Influences Microglial Activation After Cuprizone-Induced Demyelination Open
Multiple sclerosis (MS) is a chronic inflammatory CNS disease, which causes demyelinated lesions and damages white and gray matter regions. Aging is a significant factor in the progression of MS, and microglia, the immune cells of the CNS …
View article: Doublecortin expression in CD8+ T‐cells and microglia at sites of amyloid‐β plaques: A potential role in shaping plaque pathology?
Doublecortin expression in CD8+ T‐cells and microglia at sites of amyloid‐β plaques: A potential role in shaping plaque pathology? Open
Introduction One characteristic of Alzheimer's disease is the formation of amyloid‐β plaques, which are typically linked to neuroinflammation and surrounded by inflammatory cells such as microglia and infiltrating immune cells. Methods Her…
View article: Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state
Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state Open
Microglia are potential targets for therapeutic intervention in neurological and neurodegenerative diseases affecting the central nervous system. In order to assess the efficacy of therapies aimed to reduce the tissue damaging activities o…
View article: Lower extremity fractures in patients with spinal cord injury characteristics, outcome and risk factors for non-unions
Lower extremity fractures in patients with spinal cord injury characteristics, outcome and risk factors for non-unions Open
Even though modern techniques allow surgical interventions in bones with reduced mineral density, non-unions remain a common complication in patients with SCI. Risk factors for non-unions of lower extremity fractures are identified.
View article: Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus
Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus Open
Allergies and their characteristic TH2-polarized inflammatory reactions affect a substantial part of the population. Since there is increasing evidence that the immune system modulates plasticity and function of the central nervous system …
View article: Early Decompression (<8h) versus Delayed Surgical Management Improves Functional Outcome after Traumatic Cervical Spinal Cord Injury
Early Decompression (<8h) versus Delayed Surgical Management Improves Functional Outcome after Traumatic Cervical Spinal Cord Injury Open
Introduction Traumatic cervical spinal cord injury affects the individual in a multi-faceted way. Early decompression of the spinal canal is recommended. The optimal time point for this intervention has been under debate for decades. This …
View article: Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug
Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug Open
View article: Reduction in Subventricular Zone-Derived Olfactory Bulb Neurogenesis in a Rat Model of Huntington’s Disease Is Accompanied by Striatal Invasion of Neuroblasts
Reduction in Subventricular Zone-Derived Olfactory Bulb Neurogenesis in a Rat Model of Huntington’s Disease Is Accompanied by Striatal Invasion of Neuroblasts Open
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder caused by an expanded CAG repeat in exon 1 of the huntingtin gene (HTT). The primary neuropathology of HD has been attributed to the preferential degeneration…