Brandon Lam
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View article: Benchmarking overlapping community detection methods for applications in human connectomics
Benchmarking overlapping community detection methods for applications in human connectomics Open
Brain networks exhibit non-trivial modular organization, with groups of densely connected areas participating in specialized functions. Traditional community detection algorithms assign each node to one module, but this representation cann…
View article: Benchmarking overlapping community detection methods for applications in human connectomics
Benchmarking overlapping community detection methods for applications in human connectomics Open
Brain networks exhibit non-trivial modular organization, with groups of densely connected areas participating in specialized functions. Traditional community detection algorithms assign each node to one module, but this representation cann…
View article: Disease diagnostics using machine learning of B cell and T cell receptor sequences
Disease diagnostics using machine learning of B cell and T cell receptor sequences Open
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen exposures encoded by receptors on B cel…
View article: Gestational SARS-CoV-2 Infection in a Ugandan Birth Cohort: High Incidence, Mild Maternal Disease, and Evidence of Association with Transient Infant Stunting
Gestational SARS-CoV-2 Infection in a Ugandan Birth Cohort: High Incidence, Mild Maternal Disease, and Evidence of Association with Transient Infant Stunting Open
Many questions remain about the prevalence and effects of SARS-CoV-2 infection in malaria-endemic African countries like Uganda, particularly in vulnerable groups such as pregnant women. We describe SARS-CoV-2 immunoglobulin (Ig)G and IgM …
View article: Impaired innate and adaptive immune responses to BNT162b2 SARS-CoV-2 vaccination in systemic lupus erythematosus
Impaired innate and adaptive immune responses to BNT162b2 SARS-CoV-2 vaccination in systemic lupus erythematosus Open
To assess the clinical features as well as the innate and adaptive immune responses in patients with SLE following 2-dose BNT162b2 mRNA vaccination.
View article: Profiling of VEGF Receptors and Immune Checkpoints in Recurrent Respiratory Papillomatosis
Profiling of VEGF Receptors and Immune Checkpoints in Recurrent Respiratory Papillomatosis Open
Objectives Recurrent respiratory papillomatosis (RRP) is caused by human papilloma virus (HPV) infection of the aerodigestive tract that significantly impacts quality‐of‐life including the ability to communicate and breathe. Treatment was …
View article: In situ vaccination via tissue-targeted cDC1 expansion enhances the immunogenicity of chemoradiation and immunotherapy
In situ vaccination via tissue-targeted cDC1 expansion enhances the immunogenicity of chemoradiation and immunotherapy Open
Even with the prolific clinical use of next-generation cancer therapeutics, many tumors remain unresponsive or become refractory to therapy, creating a medical need. In cancer, DCs are indispensable for T cell activation, so there is a res…
View article: High rates of SARS-CoV-2 infection in pregnant Ugandan women and association with stunting in infancy
High rates of SARS-CoV-2 infection in pregnant Ugandan women and association with stunting in infancy Open
Background SARS-CoV-2 has been well studied in resource-rich areas but many questions remain about effects of infection in African populations, particularly in vulnerable groups such as pregnant women. Methods We describe SARS-CoV-2 immuno…
View article: Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor
Development and anticancer properties of Up284, a spirocyclic candidate ADRM1/RPN13 inhibitor Open
Bortezomib has been successful for treatment of multiple myeloma, but not against solid tumors, and toxicities of neuropathy, thrombocytopenia and the emergence of resistance have triggered efforts to find alternative proteasome inhibitors…
View article: Detection of SARS-CoV-2 Antibodies in Immunoglobulin Products
Detection of SARS-CoV-2 Antibodies in Immunoglobulin Products Open
View article: Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection
Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection Open
Tissue-resident immunity underlies essential host defenses against pathogens, but analysis in humans has lacked in vitro model systems where epithelial infection and accompanying resident immune cell responses can be observed en bloc. Inde…
View article: Supplementary Data from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract
Supplementary Data from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract Open
Supplementary Figures
View article: Data from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract
Data from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract Open
Current preclinical models for cervical cancer lack important clinical and pathologic features. To improve upon these models, we aimed to develop a novel, spontaneous HPV16-expressing carcinoma model that captures major aspects of HPV-asso…
View article: Supplementary Tables from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract
Supplementary Tables from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract Open
Supplementary Tables 1, 2
View article: Supplementary Tables from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract
Supplementary Tables from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract Open
Supplementary Tables 1, 2
View article: Data from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract
Data from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract Open
Current preclinical models for cervical cancer lack important clinical and pathologic features. To improve upon these models, we aimed to develop a novel, spontaneous HPV16-expressing carcinoma model that captures major aspects of HPV-asso…
View article: Supplementary Data from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract
Supplementary Data from Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract Open
Supplementary Figures
View article: An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss
An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss Open
View article: Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T cell immunity
Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T cell immunity Open
View article: Disease diagnostics using machine learning of immune receptors
Disease diagnostics using machine learning of immune receptors Open
Clinical diagnosis typically incorporates physical examination, patient history, and various laboratory tests and imaging studies, but makes limited use of the human system’s own record of antigen exposures encoded by receptors on B cells …
View article: Albumin and interferon-β fusion protein serves as an effective vaccine adjuvant to enhance antigen-specific CD8+ T cell-mediated antitumor immunity
Albumin and interferon-β fusion protein serves as an effective vaccine adjuvant to enhance antigen-specific CD8+ T cell-mediated antitumor immunity Open
Background Type I interferons (IFN) promote dendritic cells maturation and subsequently enhance generation of antigen-specific CD8 +T cell for the control of tumor. Using type I interferons as an adjuvant to vaccination could prove to be a…
View article: Repeatability and reproducibility of a handheld quantitative G6PD diagnostic
Repeatability and reproducibility of a handheld quantitative G6PD diagnostic Open
Background The introduction of novel short course treatment regimens for the radical cure of Plasmodium vivax requires reliable point-of-care diagnosis that can identify glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. While…
View article: Delivery of IL-2 to the T Cell Surface Through Phosphatidylserine Permits Robust Expansion of CD8 T Cells
Delivery of IL-2 to the T Cell Surface Through Phosphatidylserine Permits Robust Expansion of CD8 T Cells Open
The phospholipid phosphatidylserine (PS) is naturally maintained on the cytoplasmic side of the plasma membrane. Independent of apoptosis, PS is redistributed to the surface of CD8 T cells in response to TCR-mediated activation. Annexin V …
View article: 1404 A peptide mimetic of the kinase inhibitory region of suppressor of cytokine signaling-1 attenuates lymphocyte activation and lupus progression in MRL/Lpr lupus model
1404 A peptide mimetic of the kinase inhibitory region of suppressor of cytokine signaling-1 attenuates lymphocyte activation and lupus progression in MRL/Lpr lupus model Open
Background Lupus progression is driven by the aberrant activation of T and B lymphocytes which promote a dysregulated cytokine milieu and produce pathogenic antibodies. Many cytokines, including interferon gamma (IFN-γ), utilize the janus …
View article: In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential
In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential Open
As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads, variants with enhanced virulence and transmissibility have emerged. Although in vitro systems allow rapid characterization, they do not fully recapitulate the dynamic…
View article: Chirality and asymmetry increase the potency of candidate ADRM1/RPN13 inhibitors
Chirality and asymmetry increase the potency of candidate ADRM1/RPN13 inhibitors Open
Bortezomib and the other licensed 20S proteasome inhibitors show robust activity against liquid tumors like multiple myeloma, but have disappointed against solid tumors including ovarian cancer. Consequently, interest is mounting in altern…
View article: Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract
Development of a Novel Mouse Model of Spontaneous High-Risk HPVE6/E7–Expressing Carcinoma in the Cervicovaginal Tract Open
Current preclinical models for cervical cancer lack important clinical and pathologic features. To improve upon these models, we aimed to develop a novel, spontaneous HPV16-expressing carcinoma model that captures major aspects of HPV-asso…
View article: A novel pseudovirus‐based mouse model of SARS-CoV-2 infection to test COVID-19 interventions
A novel pseudovirus‐based mouse model of SARS-CoV-2 infection to test COVID-19 interventions Open
View article: Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model
Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model Open
Autoimmune diseases are driven largely by a pathogenic cytokine milieu produced by aberrantly activated lymphocytes. Many cytokines, including interferon gamma (IFN-γ), utilize the JAK/STAT pathway for signal propagation. Suppressor of Cyt…
View article: Hedgehog proteins create a dynamic cholesterol interface
Hedgehog proteins create a dynamic cholesterol interface Open
During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation. The cholesteroylated Hh morphogens play…