Explanipedia

Adapting Ferritin, a Naturally Occurring Protein Cage, to Modulate Intrinsic Agonism of OX40 Open

Whitney Shatz-Binder, Caleigh M. Azumaya, Brandon Leonard, Ivan Vuong, Jawahar Sudhamsu , et al. · 2024

Chemistry Biology Political science

Ferritin is a multivalent, self-assembling protein scaffold found in most human cell types, in addition to being present in invertebrates, higher plants, fungi, and bacteria, that offers an attractive alternative to polymer-based drug deli…

PB1481 Evaluation of the Usage of an Electronic Venous Thromboembolism Assessment Tool for Ambulatory Oncology Patients at a Canadian Community Cancer Centre Open

Ashutosh Sachdeva, A. Kurusetty, A. Kulamurugan, Jigish Khamar, Brandon Leonard · 2023

Medicine

minimal premeditation.They perceived AI as a promising tool albeit with multiple barriers to real-life use.

Antibody-guided proteases enable selective and catalytic degradation of challenging therapeutic targets Open

Matthew G. Romei, Brandon Leonard, Ingrid Kim, Hok Seon Kim, Greg A. Lazar · 2023

Chemistry Biology

The exquisite specificity, natural biological functions, and favorable development properties of antibodies make them highly effective agents as drugs. Monoclonal antibodies are particularly strong as inhibitors of systemically accessible …

Suppl Figure 6 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Medicine

Evaluation of basal BRD4 expression in HNSCC cell lines and PDXs.

Suppl Figure 2 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Medicine

Response and RTK expression of acquired cetuximab resistant HNSCC models

Tables S1-S3 and Figures S1-S2 from APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma Open

Brandon Leonard, Gabriel J. Starrett, Matthew J. Maurer, Ann L. Oberg, Mieke Van Bockstal , et al. · 2023

Medicine

Table S1 has RTqPCR primers and probe information. Table S2 has clinical information for the Dutch cohort. Table S3 has a summary of TCGA samples used in our analyses. Figure S1 has RTqPCR assay validation data. Figure S2 shows clinical co…

Suppl Figure 5 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Medicine Chemistry

Lung cancer model of acquired cetuximab resistance display increased RTK expression and sensitivity to BET inhibition

Data from APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma Open

Brandon Leonard, Gabriel J. Starrett, Matthew J. Maurer, Ann L. Oberg, Mieke Van Bockstal , et al. · 2023

Biology Medicine

Purpose: APOBEC3 DNA cytosine deaminase family members normally defend against viruses and transposons. However, deregulated APOBEC3 activity causes mutations in cancer. Because of broad expression profiles and varying mixtures of normal a…

Data from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Biology Medicine

Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resi…

Suppl Figure 6 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Biology Medicine

Evaluation of basal BRD4 expression in HNSCC cell lines and PDXs.

Suppl Figure 8 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Medicine Biology

Evaluation of RTK and BRD4 expression from clinical HNSCC datasets

Suppl Figure 4 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Medicine

Assessment of membranous EGFR expression in PECAPJ49 parental and CTXR#4 treated with and without cetuximab

Suppl Figure 1 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Medicine Biology

Schematic representing the generation of acquired cetuximab resistant HNSCC models

Supplementary Data from Newly Identified Members of FGFR1 Splice Variants Engage in Cross-talk with AXL/AKT Axis in Salivary Adenoid Cystic Carcinoma Open

Joseph O. Humtsoe, Hyun‐Su Kim, Brandon Leonard, Shizhang Ling, Bhumsuk Keam , et al. · 2023

Biology Chemistry

Supplemental Data S1 provides description on the ACC-01-XP xenograft development using ACC-01 cell line and shows list of PCR primers and other reagents used in the study. Supplemental Data S2 shows list of alternative splicing events iden…

Data from Newly Identified Members of FGFR1 Splice Variants Engage in Cross-talk with AXL/AKT Axis in Salivary Adenoid Cystic Carcinoma Open

Joseph O. Humtsoe, Hyun‐Su Kim, Brandon Leonard, Shizhang Ling, Bhumsuk Keam , et al. · 2023

Biology Medicine

Adenoid cystic carcinoma (ACC) is the second most common malignancy of the salivary gland. Although characterized as an indolent tumor, ACC often leads to incurable metastatic disease. Patients with ACC respond poorly to currently availabl…

Suppl Figure 7 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Medicine

Evaluation of RTK and Ki67 expression in PDX6282 treated with cetuximab and JQ1

Data from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Medicine Biology

Cetuximab, the FDA-approved anti-EGFR antibody for head and neck squamous cell carcinoma (HNSCC), has displayed limited efficacy due to the emergence of intrinsic and acquired resistance. We and others have demonstrated that cetuximab resi…

Suppl Figure 3 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Medicine

Determination and validation of BRD4 expression in acquired cetuximab-resistant HNSCC models.

Suppl Figure 8 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Medicine Biology

Evaluation of RTK and BRD4 expression from clinical HNSCC datasets

Suppl Figure 5 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Medicine Chemistry

Lung cancer model of acquired cetuximab resistance display increased RTK expression and sensitivity to BET inhibition

Data from APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma Open

Brandon Leonard, Gabriel J. Starrett, Matthew J. Maurer, Ann L. Oberg, Mieke Van Bockstal , et al. · 2023

Biology

Purpose: APOBEC3 DNA cytosine deaminase family members normally defend against viruses and transposons. However, deregulated APOBEC3 activity causes mutations in cancer. Because of broad expression profiles and varying mixtures of normal a…

Data from Newly Identified Members of FGFR1 Splice Variants Engage in Cross-talk with AXL/AKT Axis in Salivary Adenoid Cystic Carcinoma Open

Joseph O. Humtsoe, Hyun‐Su Kim, Brandon Leonard, Shizhang Ling, Bhumsuk Keam , et al. · 2023

Medicine Biology

Adenoid cystic carcinoma (ACC) is the second most common malignancy of the salivary gland. Although characterized as an indolent tumor, ACC often leads to incurable metastatic disease. Patients with ACC respond poorly to currently availabl…

Tables S1-S3 and Figures S1-S2 from APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma Open

Brandon Leonard, Gabriel J. Starrett, Matthew J. Maurer, Ann L. Oberg, Mieke Van Bockstal , et al. · 2023

Medicine

Table S1 has RTqPCR primers and probe information. Table S2 has clinical information for the Dutch cohort. Table S3 has a summary of TCGA samples used in our analyses. Figure S1 has RTqPCR assay validation data. Figure S2 shows clinical co…

Suppl Figure 7 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Medicine Chemistry

Evaluation of RTK and Ki67 expression in PDX6282 treated with cetuximab and JQ1

Supplementary Data from Newly Identified Members of FGFR1 Splice Variants Engage in Cross-talk with AXL/AKT Axis in Salivary Adenoid Cystic Carcinoma Open

Joseph O. Humtsoe, Hyun‐Su Kim, Brandon Leonard, Shizhang Ling, Bhumsuk Keam , et al. · 2023

Biology Chemistry

Supplemental Data S1 provides description on the ACC-01-XP xenograft development using ACC-01 cell line and shows list of PCR primers and other reagents used in the study. Supplemental Data S2 shows list of alternative splicing events iden…

Suppl Figure 3 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Medicine Chemistry

Determination and validation of BRD4 expression in acquired cetuximab-resistant HNSCC models.

Suppl Figure 1 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Medicine Chemistry Engineering

Schematic representing the generation of acquired cetuximab resistant HNSCC models

Suppl Figure 4 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Medicine

Assessment of membranous EGFR expression in PECAPJ49 parental and CTXR#4 treated with and without cetuximab

Suppl Figure 2 from BET Inhibition Overcomes Receptor Tyrosine Kinase–Mediated Cetuximab Resistance in HNSCC Open

Brandon Leonard, Toni M. Brand, Rachel A. O’Keefe, Eliot D. Lee, Yan Zeng , et al. · 2023

Chemistry Medicine

Response and RTK expression of acquired cetuximab resistant HNSCC models

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