Brandon Whitcher
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View article: Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue
Genetic Determinants of Fatty Acid Composition in Subcutaneous and Visceral Adipose Tissue Open
Objective Fatty acids in adipose tissue are key structural and metabolic regulators of cardiometabolic health, but the genetic architecture governing depot‐specific composition in subcutaneous (SAT) and visceral adipose tissue (VAT) is not…
View article: Fat Fraction and Iron Concentration in Lumbar Vertebral Bone Marrow in the UK Biobank
Fat Fraction and Iron Concentration in Lumbar Vertebral Bone Marrow in the UK Biobank Open
Background Vertebral bone marrow (VBM) plays a critical role in bone homeostasis and metabolic health. Alterations in VBM fat and iron composition have been linked to age‐related metabolic and musculoskeletal disorders, yet remain underexp…
View article: Genetic subtypes of type 2 diabetes are distinguished through the lens of abdominal MRI
Genetic subtypes of type 2 diabetes are distinguished through the lens of abdominal MRI Open
Objective This study seeks to understand type 2 diabetes (T2D) heterogeneity through detailed phenotypic characterization of various T2D genetic subtypes using advanced magnetic resonance imaging (MRI) techniques. Study design and method M…
View article: Changes in abdominal subcutaneous adipose tissue thickness associate with disease and anthropometric factors
Changes in abdominal subcutaneous adipose tissue thickness associate with disease and anthropometric factors Open
Background Three-dimensional (3D) mesh-derived phenotypes enable detailed characterisation of organ morphology and regional variation through statistical parametric maps (SPMs) and statistical shape analysis (SSA). While these techniques h…
View article: Deep learning predicts onset acceleration of 38 age-associated diseases from blood and body composition biomarkers in the UK Biobank
Deep learning predicts onset acceleration of 38 age-associated diseases from blood and body composition biomarkers in the UK Biobank Open
A major challenge in multimorbid aging is understanding how diseases co-occur and identifying high-risk groups for accelerated disease development, but to date associations in the relative onset acceleration of disease diagnoses have not b…
View article: Quantitative image quality metrics enable resource-efficient quality control of clinically applied AI-based reconstructions in MRI
Quantitative image quality metrics enable resource-efficient quality control of clinically applied AI-based reconstructions in MRI Open
Objective AI-based MRI reconstruction techniques improve efficiency by reducing acquisition times whilst maintaining or improving image quality. Recent recommendations from professional bodies suggest centres should perform quality assessm…
View article: MRI radiomics prediction modelling for pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review and meta-analysis
MRI radiomics prediction modelling for pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review and meta-analysis Open
Purpose Predicting response to neoadjuvant therapy in locally advanced rectal cancer (LARC) is challenging. Organ preservation strategies can be offered to patients with complete clinical response. We aim to evaluate MRI-derived radiomics …
View article: Identifying Four Obesity Axes Through Integrative Multiomics and Imaging Analysis
Identifying Four Obesity Axes Through Integrative Multiomics and Imaging Analysis Open
We aimed to identify distinct axes of obesity using advanced magnetic resonance imaging (MRI)–derived phenotypes. We used 24 MRI-derived fat distribution and muscle volume measures (UK Biobank; N = 33,122) to construct obesity axes through…
View article: <b>Identifying four obesity axes through integrative multi-omics and imaging analysis</b>
<b>Identifying four obesity axes through integrative multi-omics and imaging analysis</b> Open
We aimed to identify distinct axes of obesity using advanced MRI-derived phenotypes.We used 24 MRI-derived fat distribution and muscle volume measures (UK Biobank, n= 33,122) to construct obesity axes through principal component analysis (…
View article: <b>Identifying four obesity axes through integrative multi-omics and imaging analysis</b>
<b>Identifying four obesity axes through integrative multi-omics and imaging analysis</b> Open
We aimed to identify distinct axes of obesity using advanced MRI-derived phenotypes.We used 24 MRI-derived fat distribution and muscle volume measures (UK Biobank, n= 33,122) to construct obesity axes through principal component analysis (…
View article: Detecting Scoliosis at Scale Using Automated Cobb Angle Analysis in the UK Biobank
Detecting Scoliosis at Scale Using Automated Cobb Angle Analysis in the UK Biobank Open
Purpose Adult degenerative scoliosis arises after skeletal maturity in an initially normal spine, primarily driven by age-related degeneration. The Cobb angle, the angle between the most tilted vertebrae typically derived from radiographs,…
View article: Fat fraction and iron concentration in lumbar vertebral bone marrow in the UK Biobank
Fat fraction and iron concentration in lumbar vertebral bone marrow in the UK Biobank Open
Objectives This study aimed to assess the vertebrae bone marrow (VBM) fat and iron concentration in the UK Biobank imaging cohort (N = 26,531) using magnetic resonance imaging (MRI). Methods We measured the VBM fat using two approaches: fa…
View article: Deep learning predicts onset acceleration of 38 age-associated diseases from blood and body composition biomarkers in the UK Biobank
Deep learning predicts onset acceleration of 38 age-associated diseases from blood and body composition biomarkers in the UK Biobank Open
A major challenge in multimorbid aging is understanding how diseases co-occur and identifying high-risk groups for accelerated disease development, but to date associations in the relative onset acceleration of disease diagnoses have not b…
View article: Changes in Abdominal Subcutaneous Adipose Tissue Thickness Associate with Disease and Anthropometric Factors
Changes in Abdominal Subcutaneous Adipose Tissue Thickness Associate with Disease and Anthropometric Factors Open
Background: Quantifying abdominal subcutaneous adipose tissue (ASAT) thickness may give new insights into phenotypic variations underlying metabolic diseases including obesity and type 2 diabetes. Methods: We used morphometric methods to s…
View article: MRI‐Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites
MRI‐Based Genetic Studies Reveal Specific Genetic Variants and Disease Risks Associated With Fat Distribution Across Anatomical Sites Open
Objective: To investigate the genetic determinants of fat distribution across anatomical sites and their implications for health outcomes. Methods: We analyzed neck‐to‐knee MRI data from the UK Biobank ( n = 37,589) to measure fat at vario…
View article: <scp>M</scp> <scp>RI</scp> assessment of adipose tissue fatty acid composition in the <scp>UK</scp> Biobank and its association with diet and disease
<span>M</span> <span>RI</span> assessment of adipose tissue fatty acid composition in the <span>UK</span> Biobank and its association with diet and disease Open
Objective This study aimed to assess the fatty acid (FA) composition of abdominal subcutaneous and visceral adipose tissue (ASAT and VAT, respectively) in the UK Biobank imaging cohort ( N = 33,823) using magnetic resonance imaging (MRI). …
View article: MRI assessment of adipose tissue fatty acid composition in the UK Biobank and its association with diet and disease
MRI assessment of adipose tissue fatty acid composition in the UK Biobank and its association with diet and disease Open
Objectives This study aimed to assess the fatty acid (FA) composition of abdominal subcutaneous (ASAT) and visceral (VAT) adipose tissue in the UK Biobank imaging cohort (N = 33,823) using magnetic resonance imaging (MRI). Methods We measu…
View article: Genetic evidence for distinct biological mechanisms that link adiposity to type 2 diabetes: towards precision medicine
Genetic evidence for distinct biological mechanisms that link adiposity to type 2 diabetes: towards precision medicine Open
We aimed to unravel the mechanisms connecting adiposity to type 2 diabetes. We employed MR-Clust to cluster independent genetic variants associated with body fat percentage (388 variants) and BMI (540 variants) based on their impact on typ…
View article: Genetic Evidence for Distinct Biological Mechanisms That Link Adiposity to Type 2 Diabetes: Toward Precision Medicine
Genetic Evidence for Distinct Biological Mechanisms That Link Adiposity to Type 2 Diabetes: Toward Precision Medicine Open
We aimed to unravel the mechanisms connecting adiposity to type 2 diabetes. We used MR-Clust to cluster independent genetic variants associated with body fat percentage (388 variants) and BMI (540 variants) based on their impact on type 2 …
View article: Genetic evidence for distinct biological mechanisms that link adiposity to type 2 diabetes: towards precision medicine
Genetic evidence for distinct biological mechanisms that link adiposity to type 2 diabetes: towards precision medicine Open
We aimed to unravel the mechanisms connecting adiposity to type 2 diabetes. We employed MR-Clust to cluster independent genetic variants associated with body fat percentage (388 variants) and BMI (540 variants) based on their impact on typ…
View article: Precision MRI phenotyping of muscle volume and quality at a population scale
Precision MRI phenotyping of muscle volume and quality at a population scale Open
Introduction: Magnetic resonance imaging (MRI) enables direct measurements of muscle volume and quality, allowing for an in-depth understanding of their associations with anthropometric traits, and health conditions. However, it is unclear…
View article: Liver shape analysis using statistical parametric maps at population scale
Liver shape analysis using statistical parametric maps at population scale Open
Background Morphometric image analysis enables the quantification of differences in the shape and size of organs between individuals. Methods Here we have applied morphometric methods to the study of the liver by constructing surface meshe…
View article: Kidney shape statistical analysis: associations with disease and anthropometric factors
Kidney shape statistical analysis: associations with disease and anthropometric factors Open
Background Organ measurements derived from magnetic resonance imaging (MRI) have the potential to enhance our understanding of the precise phenotypic variations underlying many clinical conditions. Methods We applied morphometric methods t…
View article: Kidney Shape Statistical Analysis: Associations with Disease and Anthropometric Factors
Kidney Shape Statistical Analysis: Associations with Disease and Anthropometric Factors Open
Background Organ measurements derived from magnetic resonance imaging (MRI) have the potential to enhance our understanding of the precise phenotypic variations underlying many clinical conditions. Methods We applied morphometric methods t…
View article: Abdominal imaging associates body composition with COVID-19 severity
Abdominal imaging associates body composition with COVID-19 severity Open
The main drivers of COVID-19 disease severity and the impact of COVID-19 on long-term health after recovery are yet to be fully understood. Medical imaging studies investigating COVID-19 to date have mostly been limited to small datasets a…
View article: Precision MRI phenotyping of muscle volume and quality at a population scale
Precision MRI phenotyping of muscle volume and quality at a population scale Open
Introduction Magnetic resonance imaging (MRI) enables direct measurements of muscle volume and quality, allowing for an in-depth understanding of their associations with anthropometric traits, and health conditions. However, it is unclear …
View article: Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling
Improving the accuracy of fatty liver index to reflect liver fat content with predictive regression modelling Open
Background The fatty liver index (FLI) is frequently used as a non-invasive clinical marker for research, prognostic and diagnostic purposes. It is also used to stratify individuals with hepatic steatosis such as non-alcoholic fatty liver …
View article: Liver Shape Analysis using Statistical Parametric Maps at Population Scale
Liver Shape Analysis using Statistical Parametric Maps at Population Scale Open
Background Morphometric image analysis enables the quantification of differences in the shape and size of organs between individuals. Methods Here we have applied morphometric methods to the study of the liver by constructing surface meshe…
View article: Cardiovascular measures from abdominal MRI provide insights into abdominal vessel genetic architecture
Cardiovascular measures from abdominal MRI provide insights into abdominal vessel genetic architecture Open
Features extracted from cardiac MRI (CMR) are correlated with cardiovascular disease outcomes such as aneurysm, and have a substantial heritable component. To determine whether disease-relevant measurements are feasible in non-cardiac spec…