Brankica Filipić
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View article: Challenges in the preclinical design and assessment of CAR-T cells
Challenges in the preclinical design and assessment of CAR-T cells Open
The advent of immunotherapy in the treatment of cancer has opened a new dimension in the management of this complex multifaceted disease, bringing hope to many patients whose tumors have failed to respond to conventional therapies. The ado…
View article: Strengthening the role of community pharmacy in HPV vaccination roll-out in Serbia at national and local levels: A pharmacy-based education approach
Strengthening the role of community pharmacy in HPV vaccination roll-out in Serbia at national and local levels: A pharmacy-based education approach Open
Cervical cancer is a significant public health concern in Serbia, with high morbidity and mortality rates (27 and 14.2 per 100,000 women, respectively in 2020). The primary cause of cervical cancer is human papillomavirus (HPV) infection, …
View article: Structural hybridization as a tool for developing novel biologically active analogues of protulactone A
Structural hybridization as a tool for developing novel biologically active analogues of protulactone A Open
View article: Pneumococcal vaccination in older adults: A useful, but underused weapon
Pneumococcal vaccination in older adults: A useful, but underused weapon Open
Streptococcus pneumoniae is a Gram-positive coccus with a characteristic oval shape, microscopically most often grouped in pairs (diplococci). It is encapsulated microorganism responsible for a variety of infections in humans, which can be…
View article: A Longitudinal Study of Escherichia coli Clinical Isolates from the Tracheal Aspirates of a Paediatric Patient—Strain Type Similar to Pandemic ST131
A Longitudinal Study of Escherichia coli Clinical Isolates from the Tracheal Aspirates of a Paediatric Patient—Strain Type Similar to Pandemic ST131 Open
Escherichia coli is a Gram-negative bacterium and part of the intestinal microbiota. However, it can cause various diarrhoeal illnesses, i.e., traveller’s diarrhoea, dysentery, and extraintestinal infections when the bacteria are transloca…
View article: Editorial: Research implications on microbial virulence factors, resistance, and new therapeutic strategies in the context of future infectious disease therapies
Editorial: Research implications on microbial virulence factors, resistance, and new therapeutic strategies in the context of future infectious disease therapies Open
View article: Evaluation of novel compounds as anti-bacterial or anti-virulence agents
Evaluation of novel compounds as anti-bacterial or anti-virulence agents Open
Antimicrobial resistance is a global threat, leading to an alarming increase in the prevalence of bacterial infections that can no longer be treated with available antibiotics. The World Health Organization estimates that by 2050 up to 10 …
View article: Human papillomaviruses and cervical cancer from the perspective of the World Health Organisation initiative for cervical cancer elimination
Human papillomaviruses and cervical cancer from the perspective of the World Health Organisation initiative for cervical cancer elimination Open
Human papillomaviruses (HPV) are the most common sexually transmitted pathogens worldwide, leading to infections with a wide range of clinical manifestations: from benign conditions to different types of cancer in women and men as well. Ce…
View article: The influence of various sample storage conditions and sample bacterial contamination on concentrations of routine biochemical parameters
The influence of various sample storage conditions and sample bacterial contamination on concentrations of routine biochemical parameters Open
Background: The pre-analytical (PA) phase is the most vulnerable phase of the laboratory testing procedure, with critical procedures-collection, handling, sample transport, and time and temperature of sample storage. This study aimed to ex…
View article: Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines
Nanoparticle-Based Adjuvants and Delivery Systems for Modern Vaccines Open
Ever since the development of the first vaccine, vaccination has had the great impact on global health, leading to the decrease in the burden of numerous infectious diseases. However, there is a constant need to improve existing vaccines a…
View article: Virulence potential of multidrug-resistant Acinetobacter baumannii isolates from COVID-19 patients on mechanical ventilation: The first report from Serbia
Virulence potential of multidrug-resistant Acinetobacter baumannii isolates from COVID-19 patients on mechanical ventilation: The first report from Serbia Open
Since the WHO declared the COVID-19 pandemic in March 2020, the disease has spread rapidly leading to overload of the health system and many of the patients infected with SARS-CoV-2 needed to be admitted to the intensive care unit (ICU). A…
View article: The landscape of nanomedicines: An expert perspective
The landscape of nanomedicines: An expert perspective Open
The field of nanotechnology is at the forefront of a scientific revolution, where the term "nano" transcends mere size and opens the door to enormous possibilities. In the context of drug development, the selection of a suitable drug deliv…
View article: Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin
Selenium nanoparticles render pandrug-resistant Acinetobacter baumannii susceptible to colistin Open
Colistin is used as a “last resort” drug in the treatmentof carbapenem-resistant Acinetobacter baumanniiinfections. Though not the most convenient option due tothe serious side effects, this antibiotic can be very efficientif administered …
View article: C-Protein α-Antigen Modulates the Lantibiotic Thusin Resistance in Streptococcus Agalactiae
C-Protein α-Antigen Modulates the Lantibiotic Thusin Resistance in Streptococcus Agalactiae Open
Screening for producers of potent antimicrobial peptides, resulted in the isolation of Bacillus cereus BGNM1 with strong antimicrobial activity against Listeria monocytogenes. Genome sequence analysis revealed that BGNM1 contains the gene …
View article: Genomic Characteristics of Colistin-Resistant Salmonella enterica subsp. enterica Serovar Infantis from Poultry Farms in the Republic of Serbia
Genomic Characteristics of Colistin-Resistant Salmonella enterica subsp. enterica Serovar Infantis from Poultry Farms in the Republic of Serbia Open
The antimicrobial susceptibility testing was conducted on 174 single isolates from poultry farms in Serbia and it was determined that seven Salmonella spp. were multidrug resistant. Sixteen serotypes were detected, but only serotype Infant…
View article: Shotgun metagenomics reveals differences in antibiotic resistance genes among bacterial communities in Western Balkans glacial lakes sediments
Shotgun metagenomics reveals differences in antibiotic resistance genes among bacterial communities in Western Balkans glacial lakes sediments Open
Long-term overuse of antibiotics has driven the propagation and spreading of antibiotic resistance genes (ARGs) such as efflux pumps in the environment, which can be transferred to clinically relevant pathogens. This study explored the abu…
View article: Pseudomonas aeruginosa quorum sensing inhibition by clinical isolate Delftia tsuruhatensis 11304: involvement of N-octadecanoylhomoserine lactones
Pseudomonas aeruginosa quorum sensing inhibition by clinical isolate Delftia tsuruhatensis 11304: involvement of N-octadecanoylhomoserine lactones Open
View article: Probiotic Properties of Lactic Acid Bacteria Isolated from Croatian Fresh Soft Cheese and Serbian White Pickled Cheese
Probiotic Properties of Lactic Acid Bacteria Isolated from Croatian Fresh Soft Cheese and Serbian White Pickled Cheese Open
The aim of this study is to gain insight into the probiotic potential of autochthonous lactic acid bacteria (LAB) isolated from artisanal fresh soft and white pickled cheeses. Eleven out of 86 LAB isolates from traditionally produced artis…
View article: Brevibacillus laterosporus strains BGSP7, BGSP9 and BGSP11 isolated from silage produce broad spectrum multi-antimicrobials
Brevibacillus laterosporus strains BGSP7, BGSP9 and BGSP11 isolated from silage produce broad spectrum multi-antimicrobials Open
Bacteria active against multi-drug resistant pathogens, isolated by direct selection of colonies from clover silage samples, produce zones of inhibition against two Gram-negative (Klebsiella pneumoniae Ni9 and Pseudomonas aeruginosa MMA83)…
View article: Active immunotherapy of cancer: An overview of therapeutic vaccines
Active immunotherapy of cancer: An overview of therapeutic vaccines Open
Cancer is one of the leading causes of morbidity and mortality worldwide and great efforts are underway to develop new therapeutic protocols. One of the approaches is immunotherapy which uses the immune system and its components to fight a…
View article: Adjuvants in vaccines registered for human use
Adjuvants in vaccines registered for human use Open
Vaccination is one of the most efficient strategies for prevention of infection diseases, but with introduction of sub-unit vaccines with lower immunogenicity adjuvants were needed to enhance the immune response. The term adjuvant is from …
View article: <i>Lra</i>I from<i>Lactococcus raffinolactis</i>BGTRK10-1, an Isoschizomer of<i>Eco</i>RI, Exhibits Ion Concentration-Dependent Specific Star Activity
<i>Lra</i>I from<i>Lactococcus raffinolactis</i>BGTRK10-1, an Isoschizomer of<i>Eco</i>RI, Exhibits Ion Concentration-Dependent Specific Star Activity Open
Restriction enzymes are the main defence system against foreign DNA, in charge of preserving genome integrity. Lactococcus raffinolactis BGTRK10-1 expresses Lra I Type II restriction-modification enzyme, whose activity is similar to that s…
View article: Virulence traits associated with Burkholderia cenocepacia ST856 epidemic strain isolated from cystic fibrosis patients
Virulence traits associated with Burkholderia cenocepacia ST856 epidemic strain isolated from cystic fibrosis patients Open
View article: Uncovering Differences in Virulence Markers Associated with Achromobacter Species of CF and Non-CF Origin
Uncovering Differences in Virulence Markers Associated with Achromobacter Species of CF and Non-CF Origin Open
Achromobacter spp. are recognized as emerging pathogens in hospitalized as well as in cystic fibrosis (CF) patients. From 2012 to 2015, we collected 69 clinical isolates (41 patient) of Achromobacter spp. from 13 patients wit…
View article: Diversity and antibiotic susceptibility of autochthonous dairy enterococci isolates: are they safe candidates for autochthonous starter cultures?
Diversity and antibiotic susceptibility of autochthonous dairy enterococci isolates: are they safe candidates for autochthonous starter cultures? Open
Enterococci represent the most controversial group of dairy bacteria. They are found to be the main constituent of many traditional Mediterranean dairy products and contribute to their characteristic taste and flavor. On the other hand, du…
View article: Carbapenem-Resistant Acinetobacter baumannii from Serbia: Revision of CarO Classification
Carbapenem-Resistant Acinetobacter baumannii from Serbia: Revision of CarO Classification Open
Carbapenem-resistant A. baumannii present a significant therapeutic challenge for the treatment of nosocomial infections in many European countries. Although it is known that the gradient of A. baumannii prevalence increases from northern …
View article: Resistance to antibiotics in Lacid acid bacteria - strain Lactococcus
Resistance to antibiotics in Lacid acid bacteria - strain Lactococcus Open
Lactic acid bacteria (LAB) are widely used in the food industry, especially in the production of fermented dairy products and meat. The most studied species among Lis Lactococcus lactis. L. lactis strains are of great importance in the pro…