Branko Branković
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View article: MMP-9 Activation via ROS/NF-κB Signaling in Colorectal Cancer Progression: Molecular Insights and Prognostic–Therapeutic Perspectives
MMP-9 Activation via ROS/NF-κB Signaling in Colorectal Cancer Progression: Molecular Insights and Prognostic–Therapeutic Perspectives Open
Colorectal cancer (CRC) is characterized by complex interactions between inflammation, oxidative stress, and extracellular matrix remodeling. Recent studies have highlighted the significance of the reactive oxygen species (ROS)–nuclear fac…
View article: Mortality and causes of death in Serbia: redistribution of garbage codes to ischemic heart disease
Mortality and causes of death in Serbia: redistribution of garbage codes to ischemic heart disease Open
Background Cardiovascular diseases are ranked as the number one cause of death in Serbia, and one-fifth of them present ischemic heart disease (IHD). However, the physicians certifying the cause of death have either not been adequately inv…
View article: Surgical treatment of hemorrhoidal disease
Surgical treatment of hemorrhoidal disease Open
Hemorrhoidal disease (HD) is a condition characterized by enlarged normally present anal cushions or nodules accompanied by clinical symptoms. HD of grade I and II, is primarily treated conservatively with medication (creams and phlebotoni…
View article: The Importance of Immunohistochemical Heterogeneous Expression of MMR Protein in Patients with Colorectal Cancer in Stage II and III of the Disease
The Importance of Immunohistochemical Heterogeneous Expression of MMR Protein in Patients with Colorectal Cancer in Stage II and III of the Disease Open
Background and objectives: In patients with colorectal cancer (CRC), heterogeneous expression of Mismatch repair (MMR) proteins can manifest itself in several different forms and is not such a rare phenomenon. Therefore, it is very importa…
View article: Xanthine oxidase activity and its relation to oxidative stress in human colorectal and prostate cancer
Xanthine oxidase activity and its relation to oxidative stress in human colorectal and prostate cancer Open
Summary. Colorectal cancer (CRC) and prostate cancer (PC) are the most often diagnosed cancers and the main reason for mortality connected to tumor diseases. There is still a shortage of examination of mechanisms including the influence of…
View article: Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue
Altered arginine metabolism in colon cancer: A sign of increased proliferative potential of tumor-adjacent tissue Open
Colorectal cancer (CRC) is one of the most frequent forms of malignant tumors in the human population. The literature data about the role of arginine metabolism in CRC point out its double-faced role. In three tissue specimens of 50 patien…
View article: THE IMPORTANCE OF URATE PATHWAY ENZYMES ACTIVITY AND ITS RELATION WITH OXIDATIVE STRESS IN PROGRESSION AND INVASION OF HUMAN COLORECTAL CANCER
THE IMPORTANCE OF URATE PATHWAY ENZYMES ACTIVITY AND ITS RELATION WITH OXIDATIVE STRESS IN PROGRESSION AND INVASION OF HUMAN COLORECTAL CANCER Open
Colorectal cancer (CRC) is one of the main reasons for the mortality connected with tumor diseases.There is still a shortage of examination including the influence of urate pathway enzymes in the progressiveness and invasion of CRC, so the…
View article: Prognostic Value and Immunohistochemical Analysis of Mismatch Repair Deficiency in Patients with Stage II and III Colorectal Carcinoma—A Single-Center Study
Prognostic Value and Immunohistochemical Analysis of Mismatch Repair Deficiency in Patients with Stage II and III Colorectal Carcinoma—A Single-Center Study Open
Background and objectives: Deficient mismatch repair (MMR) status is associated with good prognosis but poor therapeutic response to adjuvant chemotherapy in patients with colorectal cancer. However, there are some opposed arguments consid…
View article: Larrey diaphragmatic hernia in an adult
Larrey diaphragmatic hernia in an adult Open
Introduction. Larrey hernia is a very rare type of the left sided parasternal congenital hernia with the incidence of 1?3% of all anterior diaphragmatic hernias. Case report. The paper describes Larrey congenital diaphragmatic hernia in an…
View article: SURGICAL SITE INFECTION AFTER ELECTIVE COLORECTAL SURGERY: A REVIEW OF PREVENTION
SURGICAL SITE INFECTION AFTER ELECTIVE COLORECTAL SURGERY: A REVIEW OF PREVENTION Open
Colon cancer is the third leading cause of the disease in the world.In the world, about 1,200,000 people suffer from it every year.The leading cause of morbidity and mortality with about 500,000 deaths per year, SSI (surgical site infectio…
View article: PERINEAL HERNIA AFTER ABDOMINOPERINEAL LAPAROSCOPIC RESECTION – CASE REPORT
PERINEAL HERNIA AFTER ABDOMINOPERINEAL LAPAROSCOPIC RESECTION – CASE REPORT Open
A perineal hernia can severely affect everyday activities. We represent a case of a sixty-five-year-old with perineal hernia after abdominoperineal resection for rectal cancer. Bulging in the perineum appeared 24 months following operation…
View article: PATIENTS' CONTENTMENT WITH TRANSANAL HEMORRHOIDAL DEARTERIALISATION
PATIENTS' CONTENTMENT WITH TRANSANAL HEMORRHOIDAL DEARTERIALISATION Open
Hemorrhoidectomy was the method of choice for treating grade 3 and 4 hemorrhoids. Due to a large number of complications, a new surgical treatment called transanal hemorrhoidal dearterialization (THD) was introduced. The aim of the study w…
View article: MOLECULAR MECHANISMS OF ISCHEMIC-REPERFUSION INJURY DURING LIVER RESECTION FOR COLORECTAL CANCER METASTASES- STUDY PROTOCOL
MOLECULAR MECHANISMS OF ISCHEMIC-REPERFUSION INJURY DURING LIVER RESECTION FOR COLORECTAL CANCER METASTASES- STUDY PROTOCOL Open
Bleeding during liver resection is a significant threat to the clinical outcome. Portal triad occlusion with complete ischemia of the liver flow of hepatoduodenal ligament is a well-documented, safe and useful way to reduce this problem. A…
View article: PILONIDAL DISEASE
PILONIDAL DISEASE Open
Pilonidal disease is a common and well-recognized medical condition. It affects people in reproductive age, especially men and in combination with in-patient and outpatient treatment and absence from work it causes a considerable socioecon…
View article: Road to organ preservation in locally advanced rectal cancer
Road to organ preservation in locally advanced rectal cancer Open
Introduction. In the past 20 years there has been significant change in the treatment of rectal cancer, especially in terms of multimodal approach. Surgery is, at least for now, the mainstay treatment for resectable rectal cancer. Preopera…
View article: Necrotizing soft tissue infection in pregnancy
Necrotizing soft tissue infection in pregnancy Open
Introduction. Necrotizing soft tissue infection (NSTI) is a life-threatening condition, characterized by widely spread necrosis of skin, subcutaneous fat, fascia and muscles. Treatment involves surgical debridement and broad-spectrum antim…
View article: Necrotizing soft tissue infections of perianal and perineal region - still lethal infection
Necrotizing soft tissue infections of perianal and perineal region - still lethal infection Open
Introduction/Objective. Necrotizing soft tissue infection is a life-threatening condition, characterized by widely spread necrosis of the skin, subcutaneous adipose tissue, fascia, and muscle. This study aimed to determine the risk factors…
View article: Prolonged postoperative ileus after elective colorectal cancer surgery
Prolonged postoperative ileus after elective colorectal cancer surgery Open
Background/Aim. Postoperative ileus is a frequent and frustrating occurence for both, patients and surgeons after abdominal surgery. Besides clinical importance of postoperative ileus, its economic aspect is also important. The aim of this…
View article: PARAMETERS OF OXIDATIVE STRESS IN COLON CANCER TISSUE
PARAMETERS OF OXIDATIVE STRESS IN COLON CANCER TISSUE Open
Colorectal cancer is one of the most frequent neoplastic diseases in the human population, and one of the most frequent causes of death. Reactive oxygen species (ROS) are involved in the process of cancer initiation and progression. It is …
View article: TROSATIVE STRESS PARAMETERS IN COLON CANCER TUMOR, ADJACENT AND HEALTHY TISSUE
TROSATIVE STRESS PARAMETERS IN COLON CANCER TUMOR, ADJACENT AND HEALTHY TISSUE Open
Colorectal cancer is one of the most frequent human malignant diseases and one of the most common causes of malignant diseases death. Oxidative and nitrosative stress have an important role in cancer initiation and propagation. That is why…
View article: OPTIMAL TIMING FOR SURGICAL TREATMENT OF COLORECTAL LIVER METASTASES
OPTIMAL TIMING FOR SURGICAL TREATMENT OF COLORECTAL LIVER METASTASES Open
Metachronous CRCLM should be evaluated by multidisciplinary oncologic consilium. Diagnostic evaluation must be completed by dinamic CT or MR of the liver. In the case of a small number of metastases, operation could be performed immediatel…
View article: COMPLEATE MESOCOLIC EXCISION AND RIGHT HEMICOLECTOMY
COMPLEATE MESOCOLIC EXCISION AND RIGHT HEMICOLECTOMY Open
In order to understand the term complete mesocolic excision, the knowledge of anatomy is crucial. In the classical literature, mesenteric organ is described as fragmented and discontinuous. Total mesorectal excision (TME) has become the “g…