Bratislav Dejanović
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View article: An assessment of an antioxidative status in patients with multiple sclerosis using standard biochemical analyses
An assessment of an antioxidative status in patients with multiple sclerosis using standard biochemical analyses Open
Background: The study aimed to assess antioxidative status using standard biochemical analyses in multiple sclerosis patients during relapse and remission. Also, to evaluate the effects of gender, drug-modified treatment and clinical chara…
View article: The association of IL-1β, IL-1α, IL-6, and E-selectin with the diastolic dysfunction in patients with type 2 diabetes mellitus and preserved ejection fraction
The association of IL-1β, IL-1α, IL-6, and E-selectin with the diastolic dysfunction in patients with type 2 diabetes mellitus and preserved ejection fraction Open
Background/Aim. The importance of chronic inflammation, endothelial dysfunction, certain cytokines, and selectins in the development of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs) is increasingly evident and supporte…
View article: Low-grade inflammation and inflammatory mediators in individuals with prediabetes
Low-grade inflammation and inflammatory mediators in individuals with prediabetes Open
Background/Aim. Prediabetes is a condition that refers to the state of hyperglycemia not sufficiently high to reach the diagnostic values for type 2 diabetes mellitus (T2DM). This condition often precedes the appearance of T2DM. The associ…
View article: Influence of riboflavin and ultraviolet-light treatment on plasma proteins – protein S and alpha 2-antiplasmin – in relation to the time of administration
Influence of riboflavin and ultraviolet-light treatment on plasma proteins – protein S and alpha 2-antiplasmin – in relation to the time of administration Open
Background/Aim. After the introduction of a careful selection procedure for blood donors and the implementation of highly sensitive screening tests for transfusion-transmitted infections (TTIs), blood has become a very safe product concern…
View article: Agmatine reduces chlorpromazine prooxidant effects in rat hippocampus and striatum
Agmatine reduces chlorpromazine prooxidant effects in rat hippocampus and striatum Open
The use of the antidepressant drug chlorpromazine (CPZ) is linked to the occurrence of oxidative stress in some brain structures. Thus, overcoming the side effects of CPZ is of great importance. Because agmatine (AGM) can act as a free rad…
View article: Effects of agmatine on chlorpromazine-induced neuronal injury in rat
Effects of agmatine on chlorpromazine-induced neuronal injury in rat Open
This study was aimed to study the potentially beneficial effects of agmatine on oxidative/nitrosative stress development in the brain of Wistar rats during subacute chlorpromazine treatment. The animals were divided into control (0.9% sali…
View article: Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium
Disulfiram moderately restores impaired hepatic redox status of rats subchronically exposed to cadmium Open
Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1 mg CdCl2/kg BW…
View article: Effects of agmatine on chlorpromazine toxicity in the liver of Wistar rats: the possible role of oxidant/antioxidant imbalance
Effects of agmatine on chlorpromazine toxicity in the liver of Wistar rats: the possible role of oxidant/antioxidant imbalance Open
Chlorpromazine (CPZ) is a member of a widely used class of antipsychotic agents. The metabolic pathways of CPZ toxicity were examined by monitoring oxidative/nitrosative stress markers. The aim of the study was to investigate the hypothesi…
View article: Protective Effects of Agmatine against Chlorpromazine- Induced Toxicity in the Liver of Wistar Rats
Protective Effects of Agmatine against Chlorpromazine- Induced Toxicity in the Liver of Wistar Rats Open
Summary The metabolic pathways of chlorpromazine (CPZ) toxicity were tracked by assessing oxidative/nitrosative stress markers. The main objective of the study was to test the hypothesis that agmatine (AGM) prevents oxidative/nitrosative s…
View article: Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats
Agmatine protection against chlorpromazine-induced forebrain cortex injury in rats Open
This study was conducted to investigate whether agmatine (AGM) provides protection against oxidative stress induced by treatment with chlorpromazine (CPZ) in Wistar rats. In addition, the role of reactive oxygen species and efficiency of a…