Breanna Ford
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View article: Pioneering protein degradation for agricultural applications
Pioneering protein degradation for agricultural applications Open
As the world of agrochemicals is entering a race for efficient and safe modalities, there is an urgent and specific need for entirely new modes of action. Proteolysis-targeting chimeras (PROTACs) recruit naturally occurring E3 ubiquitin li…
View article: Mitohormesis reprograms macrophage metabolism to enforce tolerance
Mitohormesis reprograms macrophage metabolism to enforce tolerance Open
Macrophages generate mitochondrial reactive oxygen and electrophilic species (mtROS, mtRES) as antimicrobials during Toll-like receptor (TLR)-dependent inflammatory responses. Whether mitochondrial stress caused by these molecules impacts …
View article: Utilizing Chemoproteomic Platforms to Elucidate Toxicological Mechanisms
Utilizing Chemoproteomic Platforms to Elucidate Toxicological Mechanisms Open
A large number of pharmaceuticals, endogenous metabolites, and environmental chemicals act through covalent mechanisms with protein targets. Yet, their specific interactions with the proteome still remain poorly defined for most of these r…
View article: Metabolomic Markers of Phthalate Exposure in Plasma and Urine of Pregnant Women
Metabolomic Markers of Phthalate Exposure in Plasma and Urine of Pregnant Women Open
Phthalates are known endocrine disruptors and found in almost all people with several associated adverse health outcomes reported in humans and animal models. Limited data are available on the relationship between exposure to endocrine dis…
View article: Estrogen Signaling in Arcuate <i>Kiss1</i> Neurons Suppresses a Sex-Dependent Circuit That Promotes Dense Strong Bones in Female Mice
Estrogen Signaling in Arcuate <i>Kiss1</i> Neurons Suppresses a Sex-Dependent Circuit That Promotes Dense Strong Bones in Female Mice Open
Central estrogen signaling coordinates energy expenditure, reproduction, and in concert with peripheral estrogen impacts skeletal homeostasis in female rodents. Here, we ablate estrogen receptor alpha (ERα) in the medial basal hypothalamus…
View article: Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light
Unexpected transformation of dissolved phenols to toxic dicarbonyls by hydroxyl radicals and UV light Open
Significance Phenols are common anthropogenic and natural chemicals that contaminate drinking water sources. To reduce exposure to these compounds, hydroxyl radicals are often used as chemical oxidants during water treatment. Although this…