Explanipedia

Enhancing Circle‐of‐Care Communication in Pediatric Cancer Through Digital Health Technologies: A Scoping Review Open

Aljeena Rahat Qureshi, Kaitlyn Flegg, Ashar Siddiqui, Brendan Tao, Brenda L. Gallie · 2025

Effective communication in pediatric cancer care is crucial for informed decision‐making among patients, caregivers, and healthcare providers. This scoping review assesses evidence on digital tools designed to enhance circle‐of‐care commun…

Optic Nerve Invasion in Retinoblastoma: Impact of Eye Salvage and Adjuvant Chemotherapy Open

Zhao Feng, Junyang Zhao, Donna D’Souza, Nan Zhang, Mei Jin , et al. · 2025

Timely enucleation reduces the risk of tumor involvement at optic nerve transection. Delay in enucleation by pre-enucleation chemotherapy may reduce the effectiveness of subsequent adjuvant chemotherapy.

Update on Retinoblastoma Predisposition and Surveillance Recommendations for Children Open

Junne Kamihara, Jaclyn Schienda, Rose B. McGee, Danielle Novetsky Friedman, Surya P. Rednam , et al. · 2025

Hereditary retinoblastoma is a classic cancer predisposition syndrome with risks beginning in early infancy. About 45% of children with retinoblastoma (RB) have hereditary disease. These children are at risk for both intraocular disease an…

Retinoblastoma caused by an RB1 variant with unusually low penetrance in a Danish family Open

Pernille Axél Gregersen, Peter S. Jensen, Rikke Christensen, Dietmar Lohmann, Hilary Racher , et al. · 2024

Adjuvant Chemotherapy Improves Survival for Children With Massive Choroidal Invasion of Retinoblastoma Open

Zhao Feng, Junyang Zhao, Nan Zhang, Mei Jin, Brenda L. Gallie · 2023

Adjuvant chemotherapy significantly decreased the risk of tumor relapse and death for children with pathological MCI. For every three children treated with adjuvant chemotherapy, one systemic relapse or death could be prevented.

Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma Open

Panneerselvam Jayabal, Fuchun Zhou, Xiuye Ma, Kathryn Bondra, Barron Blackman , et al. · 2023

Supplementary Material for: Orbital complications and cost analysis of enucleation by myoconjunctival versus conventional techniques for retinoblastoma Open

Leonardo Landó, Ashwin Mallipatna, Kletke S.N., Brenda L. Gallie · 2023

Introduction: To compare complication rates and hospital costs of myoconjunctival versus conventional enucleation techniques in retinoblastoma. Methods: This retrospective cohort and cost analysis reviewed patients with retinoblastoma trea…

Metastatic Death Based on Presenting Features and Treatment for Advanced Intraocular Retinoblastoma Open

Ankit Singh Tomar, Paul T. Finger, Brenda L. Gallie, Tero Kivelä, Ashwin Mallipatna , et al. · 2022

Metachronous, non‐pineal, trilateral retinoblastoma in a patient with a seemingly reduced‐expressivity <i>RB1</i> germline deletion Open

Saga Elise Eiset, Mikkel Funding, Hilary Racher, Steffen Heegaard, Brenda L. Gallie , et al. · 2022

The clinical course of trilateral retinoblastoma can be unpredictable, and expressivity of germline RB1 variants may vary during development. We describe an unexpected fatal case of trilateral retinoblastoma with an intracranial tumor in a…

Retinoblastoma Survival Following Primary Enucleation by AJCC Staging Open

Junyang Zhao, Zhaoxun Feng, Gareth Leung, Brenda L. Gallie · 2021

Primary enucleation of the eye with retinoblastoma is a widely accessible, life-saving treatment for retinoblastoma. This study evaluated the survival of patients following primary enucleation based on AJCC 8th edition staging. Included we…

Tylectomy Safety in Salvage of Eyes with Retinoblastoma Open

Junyang Zhao, Qiyan Li, Zhao Feng, Jianping Zhang, Songyi Wu , et al. · 2021

Intraocular surgery is tabooed in retinoblastoma management, due to the concern of lethal extraocular spread. We reviewed the outcomes of consecutive children with intraocular retinoblastoma diagnosed at 29 Chinese centers between 2012–201…

Natural History of Untreated Retinoblastoma Open

Junyang Zhao, Zhaoxun Feng, Brenda L. Gallie · 2021

Treatment abandonment is a leading cause of death in children with retinoblastoma worldwide. We studied children who abandoned treatment upfront at diagnosis to delineate the natural history of untreated retinoblastoma. Studied were childr…

Asynchronous pineoblastoma is more likely after early diagnosis of retinoblastoma: a meta‐analysis Open

Marcus C. de Jong, Furqan Shaikh, Brenda L. Gallie, Wijnanda A. Kors, Robin W. Jansen , et al. · 2021

Purpose To determine the risk of patients with an early diagnosis of heritable retinoblastoma being diagnosed with TRb (or pineoblastoma) asynchronously in a later stage and its effect on screening. Methods We updated the search (PubMed an…

Response criteria for intraocular retinoblastoma: RB‐RECIST Open

Jesse L. Berry, Francis L. Munier, Brenda L. Gallie, Ashley Polski, Sona Shah , et al. · 2021

Standardized guidelines for assessing tumor response to therapy are essential for designing and conducting clinical trials. The Response Evaluation Criteria In Solid Tumors (RECIST) provide radiological standards for assessment of solid tu…

Patients presenting with metastases: stage IV uveal melanoma, an international study Open

Gaurav Garg, Paul T. Finger, Tero Kivelä, E. Rand Simpson, Brenda L. Gallie , et al. · 2021

Objective To analyse ocular and systemic findings of patients presenting with systemic metastasis. Methods and analysis It is an international, multicentre, internet-enabled, registry-based retrospective data analysis. Patients were diagno…

Survivorship, Vision and Eye Salvage Following Pars Plana Vitrectomy for Residual Active or Recurrent Retinoblastoma Open

Zhao Feng, Junyang Zhao, Qiyan Li, Songyi Wu, Liwen Jin , et al. · 2020

Evaluating laser photocoagulation for discrete retinoblastoma tumors Open

Sameh E. Soliman, Zhao Feng, Brenda L. Gallie · 2020

A Multicenter, International Collaborative Study for American Joint Committee on Cancer Staging of Retinoblastoma Open

Ankit Singh Tomar, Paul T. Finger, Brenda L. Gallie, Ashwin Mallipatna, Tero Kivelä , et al. · 2020

Impact of Systemic Chemotherapy and Delayed Enucleation on Survival of Children with Advanced Intraocular Retinoblastoma Open

Junyang Zhao, Zhao Feng, Meirong Wei, Guohua Liu, Carlos Solarte , et al. · 2020

We observed that pre-enucleation chemotherapy offered no survival benefit and timely enucleation minimized risk of metastatic death. Postenucleation chemotherapy improved survival of children with high-risk histopathology but was not usefu…

Screening for Pineal Trilateral Retinoblastoma Revisited Open

Marcus C. de Jong, Wijnanda A. Kors, Annette C. Moll, Pim de Graaf, Jonas A. Castelijns , et al. · 2019

The RB1 Story: Characterization and Cloning of the First Tumor Suppressor Gene Open

Jesse L. Berry, Ashley Polski, Webster K. Cavenee, Thaddeus P. Dryja, A. Linn Murphree , et al. · 2019

The RB1 gene is the first described human tumor suppressor gene and plays an integral role in the development of retinoblastoma, a pediatric malignancy of the eye. Since its discovery, the stepwise characterization and cloning of RB1 have …

Contents Open

John J. Sloper, Jesse Smith, Laura Ward, Justin H. Townsend, Jiong Yan , et al. · 2019

Delayed enucleation of eyes with advanced intraocular retinoblastoma increases metastatic death Open

Zhao Feng, Meirong Wei, Guohua Liu, Carlos Solarte, Bin Li , et al. · 2019

Clinically preventable causes of unfavourable retinoblastoma treatment outcomes Open

Helen Dimaras, Arunan Selvarajah, Kaitlyn Hougham, Wei Ping Sim, Jason Baoshan Hu , et al. · 2019

Optical coherence tomography guided precision management strategies for retinoblastoma Open

Sameh Gaballah, Cynthia VandenHoven, Leslie MacKeen, Brenda L. Gallie · 2019

Early life maturation of human visual system white matter is altered by monocular enucleation Open

Benjamin T. Dunkley, Marlee M. Vandewouw, Arijit Chakraborty, Margot J. Taylor, Brenda L. Gallie , et al. · 2019

Monocular enucleation early in life and the resultant lack of binocular visual input during visual development results in functional and structural brain changes in adulthood, including alterations in white matter microstructure. However, …

Abstract 3771: Oncogenes and tumour-suppressors drive differential retinoblastoma evolution Open

Adriana Salcedo, John Watson, Hilary Racher, Diane Rushlow, Shadrielle M. G. Espiritu , et al. · 2019

Unlike any other tumour type, retinoblastomas can be driven by only two tumour-initiating events: bi-allelic loss of the tumour suppressor RB1 or amplification of the MYCN oncogene. These mutations drive morphologically indistinguishable t…

Single-center retrospective study of the effectiveness and toxicity of the oral iron chelating drugs deferiprone and deferasirox Open

Nancy F. Olivieri, Amir Sabouhanian, Brenda L. Gallie · 2019

Deferiprone showed ineffectiveness and significant toxicity in most patients. Combination with low doses of first-line therapies did not improve the effectiveness of deferiprone. Exposure to deferiprone, over six years while the drug was u…

Proceedings of the Association for Research in Vision and Ophthalmology and Champalimaud Foundation Ocular Oncogenesis and Oncology Conference Open

Justine R. Smith, Jacob Pe’er, Rubens Belfort Neto, Fátima Cardoso, Richard D. Carvajal , et al. · 2019

The 2018 Ocular Oncogenesis and Oncology Conference was held through a partnership of the Association for Research in Vision and Ophthalmology (ARVO) and the Champalimaud Foundation. Twenty-one experts from international ocular oncology ce…

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Alison H. Skalet, Dan S. Gombos, Brenda L. Gallie, Jonathan W. Kim, Carol L. Shields , et al. · 2018

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