Brenda Tay
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View article: Trends in Early-Onset Colorectal Cancer in Singapore: Epidemiological Study of a Multiethnic Population
Trends in Early-Onset Colorectal Cancer in Singapore: Epidemiological Study of a Multiethnic Population Open
Background Colorectal cancer (CRC) incidence and mortality in those aged 50 years and above have decreased over the past 2 decades. However, there is a rising incidence of CRC among individuals under 50 years of age, termed early-onset col…
View article: Fragle: Universal ctDNA quantification using deep learning of fragmentomic profiles
Fragle: Universal ctDNA quantification using deep learning of fragmentomic profiles Open
Quantification of circulating tumor DNA (ctDNA) levels in blood enables non-invasive surveillance of cancer progression. Fragle is an ultra-fast deep learning-based method for ctDNA quantification directly from cell-free DNA fragment lengt…
View article: Heat selection enables highly scalable methylome profiling in cell-free DNA for noninvasive monitoring of cancer patients
Heat selection enables highly scalable methylome profiling in cell-free DNA for noninvasive monitoring of cancer patients Open
Genome-wide analysis of cell-free DNA methylation profile is a promising approach for sensitive and specific detection of many cancers. However, scaling such assays for clinical translation is impractical because of the high cost of whole-…
View article: Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden Open
Profiling of circulating tumor DNA (ctDNA) may offer a non-invasive approach to monitor disease progression. Here, we develop a quantitative method, exploiting local tissue-specific cell-free DNA (cfDNA) degradation patterns, that accurate…