Brendan Hoffe
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View article: The link between impact-induced tensile strain and dendritic spine morphology in porcine brain tissue
The link between impact-induced tensile strain and dendritic spine morphology in porcine brain tissue Open
Brain tissue as a material presents unique properties with a multitude of cell types and densities, varying degrees of axonal fiber diameters and blood vessels. These neural components are contained within a very viscous environment that u…
View article: Characterization of the Porcine Cingulate Sulcus Cytoarchitecture
Characterization of the Porcine Cingulate Sulcus Cytoarchitecture Open
Cortical folding (gyrification) is a unique process by which the brain can expand and increase surface area while confined by the boundaries of the inner wall of the skull. Although there is still much debate about the exact mechanisms con…
View article: Neuroanatomical, electrophysiological, and morphological characterization of melanin‐concentrating hormone cells coexpressing cocaine‐ and amphetamine‐regulated transcript
Neuroanatomical, electrophysiological, and morphological characterization of melanin‐concentrating hormone cells coexpressing cocaine‐ and amphetamine‐regulated transcript Open
Melanin‐concentrating hormone (MCH) cells in the hypothalamus regulate fundamental physiological functions like energy balance, sleep, and reproduction. This diversity may be ascribed to the neurochemical heterogeneity among MCH cells. One…
View article: Neuroanatomical, electrophysiological, and morphological characterization of melanin-concentrating hormone cells coexpressing cocaine- and amphetamine-regulated transcript
Neuroanatomical, electrophysiological, and morphological characterization of melanin-concentrating hormone cells coexpressing cocaine- and amphetamine-regulated transcript Open
Melanin-concentrating hormone (MCH) cells in the hypothalamus regulate fundamental physiological functions like energy balance, sleep, and reproduction. This diversity may be ascribed to the neurochemical heterogeneity among MCH cells. One…
View article: Hyperacute Excitotoxic Mechanisms and Synaptic Dysfunction Involved in Traumatic Brain Injury
Hyperacute Excitotoxic Mechanisms and Synaptic Dysfunction Involved in Traumatic Brain Injury Open
The biological response of brain tissue to biomechanical strain are of fundamental importance in understanding sequela of a brain injury. The time after impact can be broken into four main phases: hyperacute, acute, subacute and chronic. I…
View article: The Use of Pigs as a Translational Model for Studying Neurodegenerative Diseases
The Use of Pigs as a Translational Model for Studying Neurodegenerative Diseases Open
In recent years, the move to study neurodegenerative disease using larger animal models with brains that are more similar to humans has gained interest. While pigs have been used for various biomedical applications and research, it has onl…
View article: Analysis of Immediate Cellular Changes in Porcine Brains Using an Ex Vivo Model of Traumatic Brain Injury
Analysis of Immediate Cellular Changes in Porcine Brains Using an Ex Vivo Model of Traumatic Brain Injury Open
The need for a better understanding of the neural responses that occur during a head impact is of upmost importance. The movement of the head and the resulting inertial forces have been shown to create high amounts within the sulcus of the…