Brendan M. McGuire
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View article: ACR Appropriateness Criteria® Staging and Follow-Up of Primary Liver Cancer
ACR Appropriateness Criteria® Staging and Follow-Up of Primary Liver Cancer Open
View article: A Prospective, Blinded Study of Symptom Prevalence and Specificity of Porphyrin Precursors in Carriers of Acute Hepatic Porphyria
A Prospective, Blinded Study of Symptom Prevalence and Specificity of Porphyrin Precursors in Carriers of Acute Hepatic Porphyria Open
Background and Aims This study aimed to characterise symptoms and assess the prevalence of elevated urine porphyrin precursors in first‐degree relatives of acute hepatic porphyria (AHP) patients who have never experienced acute attacks and…
View article: Liver involvement in a large cohort of patients with erythropoietic protoporphyria or X-linked protoporphyria
Liver involvement in a large cohort of patients with erythropoietic protoporphyria or X-linked protoporphyria Open
Background: Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are characterized by the accumulation of protoporphyrin in the marrow, erythrocytes, plasma, skin, and liver, and present clinically with painful cutaneous p…
View article: Early Ureteroscopy and Laser Lithotripsy in the Management of Obstructing Urolithiasis With Associated Urosepsis – A Prospective Multi-institutional Study
Early Ureteroscopy and Laser Lithotripsy in the Management of Obstructing Urolithiasis With Associated Urosepsis – A Prospective Multi-institutional Study Open
View article: Conservative Stone Pathway Audit
Conservative Stone Pathway Audit Open
View article: PB2562: STUDY DESIGN OF THE AURORA TRIAL: A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF BITOPERTIN IN ERYTHROPOIETIC PROTOPORPHYRIA
PB2562: STUDY DESIGN OF THE AURORA TRIAL: A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF BITOPERTIN IN ERYTHROPOIETIC PROTOPORPHYRIA Open
Topic: 29. Iron metabolism, deficiency and overload Background: Erythropoietic protoporphyria (EPP) and X-linked protoporphyria are caused by pathogenic variants in the ferrochelatase (FECH) or 5-aminolevulinate synthase 2 (ALAS2) genes, r…
View article: CALFAN (Low γ-Glutamyl Transpeptidase (GGT) Cholestasis, Acute Liver Failure, and Neurodegeneration) Syndrome: A Case Report with 3-Year Follow-Up after Liver Transplantation in Early Adulthood
CALFAN (Low γ-Glutamyl Transpeptidase (GGT) Cholestasis, Acute Liver Failure, and Neurodegeneration) Syndrome: A Case Report with 3-Year Follow-Up after Liver Transplantation in Early Adulthood Open
CALFAN syndrome is an extremely rare disease consisting of recurrent pediatric acute liver failure (PALF), neurodegenerative diseases, and skeletal abnormalities associated with SCYL1 gene mutation. To date, three of 18 patients reported u…
View article: Future directions in acute liver failure
Future directions in acute liver failure Open
Acute liver failure (ALF) describes a clinical syndrome of rapid hepatocyte injury leading to liver failure manifested by coagulopathy and encephalopathy in the absence of pre-existing cirrhosis. The hallmark diagnostic features are a prol…
View article: Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure
Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure Open
Importance In January 2011, the US Food and Drug Administration (FDA) announced a mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications, with manufacturer compliance required by M…
View article: Role of Hepatitis C Infection in Acute Liver Injury/Acute Liver Failure in North America
Role of Hepatitis C Infection in Acute Liver Injury/Acute Liver Failure in North America Open
View article: Psychometric Properties of the Patient Reported Outcomes Measurement Information System (PROMIS) Scales in Acute Intermittent Porphyria Patients
Psychometric Properties of the Patient Reported Outcomes Measurement Information System (PROMIS) Scales in Acute Intermittent Porphyria Patients Open
Background : Acute Intermittent Porphyria (AIP) is a rare inborn error of heme biosynthesis characterized clinically by life-threatening acute neurovisceral attacks. Few studies have assessed quality of life (QoL) tools in the AIP populati…
View article: A retrospective review of outcomes following percutaneous nephrolithotomy in a tertiary referral centre
A retrospective review of outcomes following percutaneous nephrolithotomy in a tertiary referral centre Open
View article: Updated Pathway to Micro-elimination of Hepatitis C Virus in the Hemodialysis Population
Updated Pathway to Micro-elimination of Hepatitis C Virus in the Hemodialysis Population Open
Chronic hepatitis C virus (HCV) infection continues to be transmitted to hemodialysis (HD) patients within HD facilities globally. The goal of the World Health Organization to micro-eliminate HCV infection from the HD population by the yea…
View article: A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure
A novel microRNA-based prognostic model outperforms standard prognostic models in patients with acetaminophen-induced acute liver failure Open
View article: Prognostic Value of the 13C‐Methacetin Breath Test in Adults with Acute Liver Failure and Non‐acetaminophen Acute Liver Injury
Prognostic Value of the 13C‐Methacetin Breath Test in Adults with Acute Liver Failure and Non‐acetaminophen Acute Liver Injury Open
Background and Aims The 13 C‐methacetin breath test (MBT) is a noninvasive, quantitative hepatic metabolic function test. The aim of this prospective, multicenter study was to determine the utility of initial and serial 13 C‐MBT in predict…
View article: Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure
Coagulopathy, Bleeding Events, and Outcome According to Rotational Thromboelastometry in Patients With Acute Liver Injury/Failure Open
Background and Aims Patients with acute liver injury or failure (ALI/ALF) experience bleeding complications uncommonly despite an abnormal hemostatic profile. Rotational thromboelastometry (ROTEM), which assesses clot formation in whole bl…
View article: American Association for the Study of Liver Diseases Expert Panel Consensus Statement: Vaccines to Prevent Coronavirus Disease 2019 Infection in Patients With Liver Disease
American Association for the Study of Liver Diseases Expert Panel Consensus Statement: Vaccines to Prevent Coronavirus Disease 2019 Infection in Patients With Liver Disease Open
The aim of this document is to provide a concise scientific review of the currently available COVID‐19 vaccines and those in development, including mRNA, adenoviral vectors, and recombinant protein approaches. The anticipated use of COVID‐…
View article: Clinical and Neurologic Outcomes in Acetaminophen-Induced Acute Liver Failure: A 21-Year Multicenter Cohort Study
Clinical and Neurologic Outcomes in Acetaminophen-Induced Acute Liver Failure: A 21-Year Multicenter Cohort Study Open
View article: Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria
Evidence in the UK Biobank for the underdiagnosis of erythropoietic protoporphyria Open
View article: Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID‐19 Pandemic: AASLD Expert Panel Consensus Statement
Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID‐19 Pandemic: AASLD Expert Panel Consensus Statement Open
Background and Aims Coronavirus disease 2019 (COVID‐19), the illness caused by the SARS‐CoV‐2 virus, is rapidly spreading throughout the world. Hospitals and healthcare providers are preparing for the anticipated surge in critically ill pa…
View article: Alcohol consumption is associated with the severity and outcome of acute liver injury/failure
Alcohol consumption is associated with the severity and outcome of acute liver injury/failure Open
Background & Aims Non‐medical factors which contribute to the severity of acute liver failure (ALF) remain poorly defined. The association of alcohol consumption on the severity of presentation and outcome were determined in patients with …
View article: Evaluating the Patient-Reported Outcomes Measurement Information System scales in acute intermittent porphyria
Evaluating the Patient-Reported Outcomes Measurement Information System scales in acute intermittent porphyria Open
View article: Hepatocellular carcinoma surveillance: An evidence-based approach
Hepatocellular carcinoma surveillance: An evidence-based approach Open
Hepatocellular carcinoma (HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases…
View article: Patient and Family Caregiver Perspectives on Palliative Care Needs in End-Stage Liver Disease: A Qualitative Study (S855)
Patient and Family Caregiver Perspectives on Palliative Care Needs in End-Stage Liver Disease: A Qualitative Study (S855) Open
View article: Case Series Regarding Parastomal Variceal Bleeding: Presentation and Management
Case Series Regarding Parastomal Variceal Bleeding: Presentation and Management Open
Parastomal variceal bleeding (PVB) is a serious complication occurring in up to 27% of patients with an ostomy and concurrent cirrhosis and portal hypertension. The management of PVB is difficult and there are no clear guidelines on this m…
View article: Current guidelines for chemoembolization for hepatocellular carcinoma: Room for improvement?
Current guidelines for chemoembolization for hepatocellular carcinoma: Room for improvement? Open
Transarterial chemoembolization (TACE) is the most common oncologic therapy used according to the American Association for the Study of Liver Diseases (AASLD) guidelines established in 2005, revised in 2011. The purpose of this study was t…
View article: The Natural History of Severe Acute Liver Injury
The Natural History of Severe Acute Liver Injury Open
A majority of ALI cases are due to APAP, 93% of whom will improve rapidly and fully recover, while non-APAP patients have a far greater risk of poor outcome and should be targeted for early referral to a liver transplant center.
View article: Trans-arterial chemoembolization of hepatocellular carcinoma is efficacious, regardless of hospital characteristics or TACE volume
Trans-arterial chemoembolization of hepatocellular carcinoma is efficacious, regardless of hospital characteristics or TACE volume Open
View article: Unusually High Rates of Hepatocellular Carcinoma After Treatment With Direct-Acting Antiviral Therapy for Hepatitis C Related Cirrhosis
Unusually High Rates of Hepatocellular Carcinoma After Treatment With Direct-Acting Antiviral Therapy for Hepatitis C Related Cirrhosis Open
View article: Heat stroke leading to acute liver injury & failure: A case series from the Acute Liver Failure Study Group
Heat stroke leading to acute liver injury & failure: A case series from the Acute Liver Failure Study Group Open
Background & Aims In the United States, nearly 1000 annual cases of heat stroke are reported but the frequency and outcome of severe liver injury in such patients is not well described. The aim of this study was to describe cases of acute …