Brendan O’Sullivan
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View article: Transcriptomic Plasticity of Human Alveolar Macrophages Revealed by Single-Cell RNA Sequencing Following Drug Exposure: Implications for Therapeutic Development
Transcriptomic Plasticity of Human Alveolar Macrophages Revealed by Single-Cell RNA Sequencing Following Drug Exposure: Implications for Therapeutic Development Open
Alveolar macrophages (AM) must perform three seemingly opposing roles including homeostasis, driving inflammation, and facilitating tissue repair. Whilst there is now consensus (supported by a large body of human single cell RNA sequencing…
View article: Transcriptomic Plasticity of Human Alveolar Macrophages Revealed by Single-Cell RNA Sequencing Following Drug Exposure: Implications for Therapeutic Development
Transcriptomic Plasticity of Human Alveolar Macrophages Revealed by Single-Cell RNA Sequencing Following Drug Exposure: Implications for Therapeutic Development Open
Alveolar macrophages (AM) must perform three seemingly opposing roles including homeostasis, driving inflammation, and facilitating tissue repair. Whilst there is now consensus (supported by a large body of human single cell RNA sequencing…
View article: Expanding the Reach of Laparoscopic Surgery: Combined Methylene Blue and Embolization Coil Marking for Preoperative Abdominal Tumor Localization
Expanding the Reach of Laparoscopic Surgery: Combined Methylene Blue and Embolization Coil Marking for Preoperative Abdominal Tumor Localization Open
Small lesions present a technical challenge for surgical excision due to poor intraoperative localization laparoscopically, resulting in suboptimal outcomes such as conversion to laparotomy. Here, we present the case of a 79-year-old man w…
View article: Immunological Landscapes in Lung Transplantation: Insights from T Cell Profiling in BAL and PBMC
Immunological Landscapes in Lung Transplantation: Insights from T Cell Profiling in BAL and PBMC Open
Lung transplant recipients frequently encounter immune-related complications, including chronic lung allograft dysfunction (CLAD). Monitoring immune cells within the lung microenvironment is pivotal for optimizing post-transplant outcomes.…
View article: A Methodological Approach to Identify Natural Compounds with Antifibrotic Activity and the Potential to Treat Pulmonary Fibrosis Using Single-Cell Sequencing and Primary Human Lung Macrophages
A Methodological Approach to Identify Natural Compounds with Antifibrotic Activity and the Potential to Treat Pulmonary Fibrosis Using Single-Cell Sequencing and Primary Human Lung Macrophages Open
Idiopathic pulmonary fibrosis (IPF) is the most common and lethal form of the interstitial pneumonias. The cause of the disease is unknown, and new therapies that stop or reverse disease progression are desperately needed. Recent advances …
View article: Single-Cell Profiling of Cells in the Lung of a Patient with Chronic Hypersensitivity Pneumonitis Reveals Inflammatory Niche with Abundant CD39+ T Cells with Functional ATPase Phenotype: A Case Study
Single-Cell Profiling of Cells in the Lung of a Patient with Chronic Hypersensitivity Pneumonitis Reveals Inflammatory Niche with Abundant CD39+ T Cells with Functional ATPase Phenotype: A Case Study Open
This study investigated immune cell characteristics in chronic hypersensitivity pneumonitis (HP), focusing on CD39-expressing cells’ impact on inflammation and tissue remodelling. Lung tissue from an HP patient was analysed using single-ce…
View article: Inter- and Intra-Observer Agreement of PD-L1 SP142 Scoring in Breast Carcinoma—A Large Multi-Institutional International Study
Inter- and Intra-Observer Agreement of PD-L1 SP142 Scoring in Breast Carcinoma—A Large Multi-Institutional International Study Open
The assessment of PD-L1 expression in TNBC is a prerequisite for selecting patients for immunotherapy. The accurate assessment of PD-L1 is pivotal, but the data suggest poor reproducibility. A total of 100 core biopsies were stained using …
View article: Managing relapsed refractory lymphoma with palliative oral chemotherapy: A multicentre retrospective study
Managing relapsed refractory lymphoma with palliative oral chemotherapy: A multicentre retrospective study Open
PEP‐C (prednisolone, etoposide, procarbazine and cyclophosphamide) is an orally administered daily chemotherapy regimen used with palliative intent in relapsed refractory lymphoma. To our knowledge, no data on PEP‐C have been reported sinc…
View article: PD-L1 Testing in Urothelial Carcinoma: Analysis of a Series of 1401 Cases Using Both the 22C3 and SP142 Assays
PD-L1 Testing in Urothelial Carcinoma: Analysis of a Series of 1401 Cases Using Both the 22C3 and SP142 Assays Open
Immune checkpoint blockade (ICB) drugs are a novel, effective treatment for advanced urothelial carcinoma. Worldwide, several different ICB drugs are approved, each developed and clinically validated with a specific PD-L1 compound diagnost…
View article: Markers of Rejection of A Lung Allograft: State of the Art
Markers of Rejection of A Lung Allograft: State of the Art Open
Chronic lung allograft dysfunction (CLAD) affects approximately 50% of all lung transplant recipients by 5 post-operative years and is the leading cause of death in lung transplant recipients. Early CLAD diagnosis or ideally prediction of …
View article: Outcomes of preoperative real-time polymerase chain reaction testing for SARS CoV-2 in elective otolaryngology surgical patients during the pandemic: a prospective cohort study
Outcomes of preoperative real-time polymerase chain reaction testing for SARS CoV-2 in elective otolaryngology surgical patients during the pandemic: a prospective cohort study Open
Real-time polymerase chain reaction (RT-PCR) is used to rule out SARS-CoV-2 prior to surgery, however few studies have evaluated patients with negative testing after surgery. Some 499 patients with negative tests were followed for 14 days …
View article: Incidents in Molecular Pathology: Frequency and Causes During Routine Testing
Incidents in Molecular Pathology: Frequency and Causes During Routine Testing Open
Context.— Errors in laboratory medicine could compromise patient safety. Good laboratory practice includes identifying and managing nonconformities in the total test process. Varying error percentages have been described in other fields bu…
View article: Itaconate controls the severity of pulmonary fibrosis
Itaconate controls the severity of pulmonary fibrosis Open
The ACOD1/itaconate axis is a pulmonary regulatory pathway that controls the severity of fibrosis and is a potential therapeutic target in IPF.
View article: Dynamics of human monocytes and airway macrophages during healthy aging and after transplant
Dynamics of human monocytes and airway macrophages during healthy aging and after transplant Open
The ontogeny of airway macrophages (AMs) in human lung and their contribution to disease are poorly mapped out. In mice, aging is associated with an increasing proportion of peripherally, as opposed to perinatally derived AMs. We sought to…
View article: PD-L1– and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease
PD-L1– and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease Open
Autoimmune diseases resulting from MHC class II-restricted autoantigen-specific T cell immunity include the systemic inflammatory autoimmune conditions rheumatoid arthritis and vasculitis. While currently treated with broad-acting immunosu…
View article: PV-0312 Distributed learning in radiomics to predict overall survival in head and neck cancer
PV-0312 Distributed learning in radiomics to predict overall survival in head and neck cancer Open
View article: PO-0733 Non-invasive imaging for tumor hypoxia: a novel validated CT and FDG-PET-based Radiomic signature.
PO-0733 Non-invasive imaging for tumor hypoxia: a novel validated CT and FDG-PET-based Radiomic signature. Open
View article: Predictive markers for anti-PD-1/PD-L1 therapy in non-small cell lung cancer—where are we?
Predictive markers for anti-PD-1/PD-L1 therapy in non-small cell lung cancer—where are we? Open
The selection of patients for immunotherapy remains challenging given the lack of highly specific and highly sensitive biomarkers. Nevertheless, it is essential that testing laboratories are able to fulfil licencing criteria by providing t…
View article: Autoimmune-Mediated Thymic Atrophy Is Accelerated but Reversible in RelB-Deficient Mice
Autoimmune-Mediated Thymic Atrophy Is Accelerated but Reversible in RelB-Deficient Mice Open
Polymorphisms impacting thymic function may decrease peripheral tolerance and hasten autoimmune disease. The NF-κB transcription factor subunit, RelB, is essential for the development and differentiation of medullary thymic epithelial cell…
View article: Multi-Center Evaluation of the Fully Automated PCR-Based Idylla™ KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer
Multi-Center Evaluation of the Fully Automated PCR-Based Idylla™ KRAS Mutation Assay for Rapid KRAS Mutation Status Determination on Formalin-Fixed Paraffin-Embedded Tissue of Human Colorectal Cancer Open
Since the advent of monoclonal antibodies against epidermal growth factor receptor (EGFR) in colorectal cancer therapy, the determination of RAS mutational status is needed for therapeutic decision-making. Most prevalent in colorectal canc…
View article: OC-0420: Radiomics in OPSCC: a novel quantitative imaging biomarker for HPV status?
OC-0420: Radiomics in OPSCC: a novel quantitative imaging biomarker for HPV status? Open
View article: Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA
Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA Open
View article: RelB-deficient dendritic cells have increased retinoic acid dehydrogenase activity and promote regulatory T cell differentiation in mice and humans
RelB-deficient dendritic cells have increased retinoic acid dehydrogenase activity and promote regulatory T cell differentiation in mice and humans Open
Peripherally-derived Foxp3+ regulatory T (pTreg) cell generation from naïve T cells in the TGF-β-enriched intestinal environment depends on specialized dendritic cells (DCs). RelB-deficient mice have an increased proportion of Treg cells i…
View article: OC-0396: Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma
OC-0396: Identification of a microRNA signature associated with risk of distant metastasis in nasopharyngeal carcinoma Open