Brendan Silbert
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View article: Feasibility of the Modified Telephone Interview for Cognitive Status (M‐TICS) in the peri‐operative environment
Feasibility of the Modified Telephone Interview for Cognitive Status (M‐TICS) in the peri‐operative environment Open
Summary Introduction Peri‐operative neurocognitive disorders are common among older adults presenting for surgery and anaesthesia. Cognitive screening is recommended to identify patients at risk for adverse neurocognitive outcomes, though …
View article: Prevalence of neurocognitive disorders 5 years after elective orthopaedic surgery
Prevalence of neurocognitive disorders 5 years after elective orthopaedic surgery Open
Summary Background Peri‐operative neurocognitive disorders are one of the most common complications affecting older adults after anaesthesia and surgery. It is not clear how exposure to surgery and anaesthesia contributes to the prevalence…
View article: Surgery outcomes in those with neurocognitive disorders
Surgery outcomes in those with neurocognitive disorders Open
The prevalence of neurocognitive disorders is rapidly increasing in high-income countries as the population ages and the prevention and management of many other life-threatening diseases improves. In Australia, dementia (including Alzheime…
View article: The cellular mechanisms associated with the anesthetic and neuroprotective properties of xenon: a systematic review of the preclinical literature
The cellular mechanisms associated with the anesthetic and neuroprotective properties of xenon: a systematic review of the preclinical literature Open
Introduction Xenon exhibits significant neuroprotection against a wide range of neurological insults in animal models. However, clinical evidence that xenon improves outcomes in human studies of neurological injury remains elusive. Previou…
View article: The relationship between inflammatory biomarker trajectory and cognitive change following elective non‐cardiac surgery in older adults
The relationship between inflammatory biomarker trajectory and cognitive change following elective non‐cardiac surgery in older adults Open
Background Surgery in the older patient is associated with short‐ and long‐term cognitive changes, including delirium, post‐operative cognitive dysfunction (POCD) and neurocognitive decline (NCD). The inflammatory response to surgery may b…
View article: Cerebrospinal fluid sampling for research of Alzheimer’s disease and other neurodegenerative diseases when lumbar punctures are performed by anaesthetists
Cerebrospinal fluid sampling for research of Alzheimer’s disease and other neurodegenerative diseases when lumbar punctures are performed by anaesthetists Open
Objectives An increasing number of people are undergoing lumbar puncture (LP) for the purposes of research. Performing LP for research purposes introduces considerations that differ from LP performed for clinical, diagnostic or therapeutic…
View article: Digital clock drawing test metrics in older patients before and after endoscopy with sedation: An exploratory analysis
Digital clock drawing test metrics in older patients before and after endoscopy with sedation: An exploratory analysis Open
Background In the postoperative period, clinically feasible instruments to monitor elderly patients' neurocognitive recovery and discharge‐readiness, especially after short‐stay procedures, are limited. Cognitive monitoring may be improved…
View article: Comparing the effect of xenon and sevoflurane anesthesia on postoperative neural injury biomarkers
Comparing the effect of xenon and sevoflurane anesthesia on postoperative neural injury biomarkers Open
General anesthesia and surgery are associated with an increase in neural injury biomarkers. Elevations of these neural injury biomarkers in the perioperative period are associated with postoperative delirium. Xenon has been shown to be pro…
View article: Preventing Delirium and Promoting Long-Term Brain Health: A Clinical Trial Design for the Perioperative Cognitive Enhancement (PROTECT) Trial
Preventing Delirium and Promoting Long-Term Brain Health: A Clinical Trial Design for the Perioperative Cognitive Enhancement (PROTECT) Trial Open
Background: Perioperative neurocognitive disorders (PND), including postoperative delirium (POD), are common in older adults and, for many, precipitate functional decline and/or dementia. Objective: In this protocol, we describe a novel mu…
View article: Impaired cognitive performance on MoCA testing at discharge in elderly patients following day endoscopy and its relationship to preoperative mild cognitive impairment
Impaired cognitive performance on MoCA testing at discharge in elderly patients following day endoscopy and its relationship to preoperative mild cognitive impairment Open
In patients admitted to hospital, preoperative mild cognitive impairment predicts postoperative complications. The effect of mild cognitive impairment on discharge readiness among the day stay surgery population is unknown. Our aims were t…
View article: Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer’s Disease
Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer’s Disease Open
Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer’s diseas…
View article: Nomenclature for Perioperative Cognitive Disorders: Reply
Nomenclature for Perioperative Cognitive Disorders: Reply Open
We thank Mathew et al. and Dr. Hogan for their comments in response to our recent nomenclature recommendations for perioperative neurocognitive disorders.1 We deeply appreciate the acknowledgment of the importance of this effort and are gr…
View article: Postoperative Cognitive Dysfunction after Sevoflurane Or Propofol General Anaesthesia in Combination with Spinal Anaesthesia for Hip Arthroplasty
Postoperative Cognitive Dysfunction after Sevoflurane Or Propofol General Anaesthesia in Combination with Spinal Anaesthesia for Hip Arthroplasty Open
It is unknown if the type of general anaesthetic used for maintenance of anaesthesia affects the incidence of postoperative cognitive dysfunction (POCD). The aim of this study was to compare the incidence of POCD in patients administered e…
View article: Tranexamic acid in coronary artery surgery: One-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial
Tranexamic acid in coronary artery surgery: One-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial Open
In this trial of patients having coronary artery surgery, tranexamic acid did not affect death or severe disability through to 1 year after surgery. Further work should be done to explore possible beneficial effects on late cardiovascular …
View article: Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018
Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018 Open
Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuro…
View article: Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery—2018
Recommendations for the Nomenclature of Cognitive Change Associated with Anaesthesia and Surgery—2018 Open
Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuro…
View article: Cognitive Function Before and After Left Heart Catheterization
Cognitive Function Before and After Left Heart Catheterization Open
Background Hospital procedures have been associated with cognitive change in older patients. This study aimed to document the prevalence of mild cognitive impairment in individuals undergoing left heart catheterization ( LHC ) before the p…