Paul Brennan
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View article: Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations
Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations Open
In spite of the growing interest in the microbiome in human cancer, there are currently only small-scale lung cancer microbiome studies conducted directly on tissue. As part of the Sherlock- Lung study, we studied the microbiomes of 940 lu…
View article: Deep ultraviolet ultrashort laser pulses for precise ablation of soft biological tissue
Deep ultraviolet ultrashort laser pulses for precise ablation of soft biological tissue Open
Laser ablation offers the potential for precisely removing pathological tissue without damaging surrounding healthy structures. Among the existing laser types, deep ultraviolet ultrashort pulsed lasers offer the highest axial precision and…
View article: Panorama of Chromosomal Instability in Lung Cancer
Panorama of Chromosomal Instability in Lung Cancer Open
Lung cancer is a highly heterogeneous disease primarily driven by tobacco smoking. About 20% of lung cancers occur among patients who have never smoked (LCINS) with differences in patient ancestry, sex, tumor histology, and clinical featur…
View article: Increase of early-onset colorectal cancer: a cohort effect
Increase of early-onset colorectal cancer: a cohort effect Open
Increasing incidence rates of early-onset colorectal cancer (eoCRC, <50 years) have been reported across multiple countries. We investigated long-term cancer incidence data (from 1995 or earlier) from Australia, Canada, England, and the…
View article: Identification and Validation of a Previously Missed Mutational Signature in Colorectal Cancer
Identification and Validation of a Previously Missed Mutational Signature in Colorectal Cancer Open
Mutational signature analysis has greatly enhanced our understanding of the mutagenic processes found in cancer and normal tissues. As part of a recent study, we analyzed 802 treatment-naïve, microsatellite-stable colorectal cancers (CRC) …
View article: Geographic and age variations in mutational processes in colorectal cancer
Geographic and age variations in mutational processes in colorectal cancer Open
Incidence rates of colorectal cancer vary geographically and have changed over time 1 . Notably, in the past two decades, the incidence of early-onset colorectal cancer, which affects individuals below 50 years of age, has doubled in many …
View article: Evaluating the return of additional findings from the 100,000 Genomes Project: A mixed-methods study exploring participant experiences of receiving secondary findings from genomic sequencing
Evaluating the return of additional findings from the 100,000 Genomes Project: A mixed-methods study exploring participant experiences of receiving secondary findings from genomic sequencing Open
Patient experiences of receiving AFs were primarily positive, and there is support for offering AFs routinely. Considerations for offering AFs in clinical practice include adapting approaches tailored to individual conditions and greater s…
View article: VOYAGER: an international consortium investigating the role of human papilloma virus and genetics in oral and oropharyngeal cancer risk and survival
VOYAGER: an international consortium investigating the role of human papilloma virus and genetics in oral and oropharyngeal cancer risk and survival Open
Head and neck cancer (HNC) is the sixth most common cancer globally. Incidence and survival rates vary significantly across geographic regions and tumor subsites. This is partly due to differences in risk factor exposure, which includes to…
View article: Geographic and age-related variations in mutational processes in colorectal cancer
Geographic and age-related variations in mutational processes in colorectal cancer Open
Colorectal cancer incidence rates vary geographically and have changed over time. Notably, in the past two decades, the incidence of early-onset colorectal cancer, affecting individuals under the age of 50 years, has doubled in many countr…
View article: Cross-ancestral GWAS identifies 29 novel variants across Head and Neck Cancer subsites
Cross-ancestral GWAS identifies 29 novel variants across Head and Neck Cancer subsites Open
In this multi-ancestry genome-wide association study (GWAS) and fine mapping study of head and neck squamous cell carcinoma (HNSCC) subsites, we analysed 19,073 cases and 38,857 controls and identified 29 independent novel loci. We provide…
View article: Supplementary Table S1 from Kidney Function and Risk of Renal Cell Carcinoma
Supplementary Table S1 from Kidney Function and Risk of Renal Cell Carcinoma Open
Supplemental table 1 shows the characteristics of the studied population for the etiology analysis.
View article: Supplementary Figure 4 from Kidney Function and Risk of Renal Cell Carcinoma
Supplementary Figure 4 from Kidney Function and Risk of Renal Cell Carcinoma Open
Supplemental figure 4 shows the estimated 5-years risk of RCC with eGFRcreat-cystC by combination of common risk factors across ages, by sex.
View article: Data from Kidney Function and Risk of Renal Cell Carcinoma
Data from Kidney Function and Risk of Renal Cell Carcinoma Open
Background:We evaluated the temporal association between kidney function, assessed by estimated glomerular filtration rate (eGFR), and the risk of incident renal cell carcinoma (RCC). We also evaluated whether eGFR could improve RCC risk d…
View article: Supplementary File 1 from Kidney Function and Risk of Renal Cell Carcinoma
Supplementary File 1 from Kidney Function and Risk of Renal Cell Carcinoma Open
Supplementary File 1 contains the risk score.
View article: Supplementary Figure 3 from Kidney Function and Risk of Renal Cell Carcinoma
Supplementary Figure 3 from Kidney Function and Risk of Renal Cell Carcinoma Open
Supplemental figure 3 shows the estimated 1-year and 5-years risk of RCC with eGFRcreat_cystC by common RCC risk factors across ages for females.
View article: Supplementary Figure 2 from Kidney Function and Risk of Renal Cell Carcinoma
Supplementary Figure 2 from Kidney Function and Risk of Renal Cell Carcinoma Open
Supplemental figure 2 shows the estimated 5-years risk of RCC with eGFRcreat_cystC by common RCC risk factors across ages for males.
View article: Supplementary Figure 1 from Kidney Function and Risk of Renal Cell Carcinoma
Supplementary Figure 1 from Kidney Function and Risk of Renal Cell Carcinoma Open
Supplemental Figure 1 shows the flowchart of the study.
View article: Supplementary Table S2 from Kidney Function and Risk of Renal Cell Carcinoma
Supplementary Table S2 from Kidney Function and Risk of Renal Cell Carcinoma Open
Supplemental table 2 shows the betas estimates and standard errors from the original risk model, the recalibrated model without and with CRP, and the updated model with eGFR.
View article: Supplementary Figure 5 from Kidney Function and Risk of Renal Cell Carcinoma
Supplementary Figure 5 from Kidney Function and Risk of Renal Cell Carcinoma Open
Supplemental figure 5 shows the comparison of the original and updated 1-year and 5-years risk of RCC for the participants with and without RCC diagnosis in the training and testing set of UKB.
View article: Supplementary Table S7 from Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization
Supplementary Table S7 from Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization Open
Supplementary Table S7 shows results of univariate analysis for 36 biopsy-confirmed nonalcoholic fatty liver disease SNPs in the PanC4 sample
View article: Supplementary Table S8 from Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization
Supplementary Table S8 from Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization Open
Supplementary Table S8 shows results of univariate analysis for 17 imaging and biopsy validated SNPs in the PanC4 sample
View article: Supplementary Table S3 from Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization
Supplementary Table S3 from Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization Open
Supplementary Table S3 shows results of univariate analysis for 36 biopsy-confirmed nonalcoholic fatty liver disease SNPs in the PanScan sample
View article: Supplementary Table S3 from Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization
Supplementary Table S3 from Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization Open
Supplementary Table S3 shows results of univariate analysis for 36 biopsy-confirmed nonalcoholic fatty liver disease SNPs in the PanScan sample
View article: Supplementary Table S5 from Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization
Supplementary Table S5 from Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization Open
Supplementary Table S5 shows results of univariate analysis for 77 chronically elevated serum alanine aminotransferase (cALT)-defined nonalcoholic fatty liver disease in the Pancreatic Cancer Case-Control Consortium (PanC4) data